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Amsacrine

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Amsacrine Basic information
Amsacrine Chemical Properties
  • Melting point:230-240 °C
  • Boiling point:563.0±60.0 °C(Predicted)
  • Density 1.2205 (rough estimate)
  • refractive index 1.6740 (estimate)
  • storage temp. Keep in dark place,Sealed in dry,2-8°C
  • pka8.55±0.10(Predicted)
  • CAS DataBase Reference51264-14-3
  • IARC2B (Vol. 76) 2000
Safety Information
  • RIDADR 3249
  • HazardClass 6.1(b)
  • PackingGroup III
  • Hazardous Substances Data51264-14-3(Hazardous Substances Data)
  • ToxicityLD50 in male, female CDF1 mice: 810 mg/m2; 729 mg/m2 orally (Pavkov)
Amsacrine Usage And Synthesis
  • DescriptionAmsacrine is a cytostatic reported to be active against adult lymphoblastic leukemia which has failed primary treatment or become resistant. Its clinical use, however, is associated with significant neuro-, gastro- and hepatotoxicity.
  • OriginatorAuckland Cancer Chemotherapy Lab (New Zealand)
  • UsesAmsacrine (Amsidyl) is used as an Investigational drug.
  • UsesAmsacrine is a drug undergoing intensive trials for severe leukemia and lymphoma. It is a cytotoxic drug that binds with DNA with expressed specificity to the adenosine–tyrosine pair, thus inhibiting DNA synthesis. It has been suggested to be used for severe leukemia. A synonym of this drug is amsidyl.
  • UsesAntineoplastic.
  • DefinitionChEBI: A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
  • brand nameAmsidyl (Parke-Davis);Amsakrin.
  • Chemical SynthesisAmsacrine, 4-(9-acridinylamino)-3-methoxyphenyl-N-methansulfonamide (30.6.11), is made by sulfonating 4-nitro-m-anisidine with methanesulfonyl chloride, which forms a sulfonyl amide 30.6.9, and the nitro group is reduced to an amino group by hydrogen, forming 4-amino-3-methoxyphenyl-N-methansulfonamide (30.6.10). Reacting this with 9-chloroacridine gives amsacrine (30.6.11).

Amsacrine Preparation Products And Raw materials
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