p-Nitroaniline consists of yellow crystals with a
pungent, faint ammonia-like odor.
Bright yellow crystalline powder or flakes with a faint, ammonia-like, slightly pungent odor.
Combustible.
Product of chromogenic reactions.
4-Nitroaniline is used in the synthesis of photorefractive polymers, as novel chromophores in analytical study. As well, due to the absorption spectrum associated with 4-Nitroaniline, it is used to de
termine catechol derivatives in syntheses.
ChEBI: A nitroaniline carrying a nitro group at position 4.
Yellow solid with a mild odor. Sinks in water.
4-Nitroaniline may be sensitive to prolonged exposure to air and light. Insoluble in water. 4-Nitroaniline is sensitive to moisture.
P-NITROANILINE may react vigorously with sulfuric acid above 392° F. 4-Nitroaniline may also react with sodium hydroxide at 266° F. Under pressure, 4-Nitroaniline may produce an explosive compound. 4-Nitroaniline is incompatible with strong oxidizers and strong reducing agents. 4-Nitroaniline is capable of explosive decomposition with strong initiators. 4-Nitroaniline will attack some forms of plastics, rubber and coatings.
Explosion risk. Toxic when absorbed by
skin. Methemoglobinemia, liver damage and eye
irritant. Questionable carcinogen.
Inhalation or ingestion causes headache, drowsiness, shortness of breath, nausea, methemoglobinemia, and unconsciousness; fingernails, lips, and ears become bluish; prolonged and excessive exposures may also cause liver damage. Contact with eyes causes irritation and possible corneal damage. Contact with skin causes irritation; continued exposure may cause same symptoms as inhalation or ingestion.
Flammability and Explosibility
Non flammable
Poison by ingestion,
intravenous, and intraperitoneal routes.
Moderately toxic by intramuscular route.
Mutation data reported. Acute symptoms of
exposure are headache, nausea, vomiting,
weakness and stupor, cyanosis and
methemoglobinemia. Chronic exposure can
cause liver damage. Experimental reproductive
effects. Combustible when exposed to
heat or flame. See NITRATES for explosion
and disaster hazards. To fight fire, use water
spray or mist, foam, dry chemical, CO2.
Vigorous reaction with sulfuric acid above
200°C. Reaction with sodium hydroxide at
13O°C under pressure may produce the
explosive sodium-4-nitrophenoxide. When
heated to decomposition it emits toxic
fumes of NOx. See also m-
NITROANILINE, o-NITROANILINE,
NITRO COMPOUNDS OF AROMATIC
HYDROCARBONS, and ANILINE
DYES.
p-Nitroaniline is used as an intermediate in the manufacture of dyes; antioxidants, pharmaceuticals, antiozonants, colors, pigments and pesticides.
p-Nitroaniline has been tested in
several strains of S. typhimurium. It was mutagenic in strain
TA98 but not in strains TA97, TA100, TA1535, and TA1537,
with and without S9. It caused gene mutation in mouse
lymphoma cells and chromosomal aberrations in CHO
cells in the presence of S9.
Biological. A Pseudomonas sp. strain P6, isolated from a Matapeake silt loam, was grown using
a yeast extract. After 8 d, 4-nitroaniline degraded completely to carbon dioxide (Zeyer and
Kearney, 1983). In activated sludge inoculum, following a 20-d adaptation period, no degradation
was observed (Pitter, 1976).
Chemical/Physical: Spacek et al. (1995) investigated the photodegradation of 4-nitroaniline
using titanium dioxide-UV light and Fenton’s reagent (hydrogen peroxide:substance – 10:1; Fe2+
2.5 x 10-4 mol/L). Both experiments were conducted at 25 °C. The decomposition rate of 4-nitroaniline
was very high by the photo-Fenton reaction in comparison to titanium dioxide-UV light (λ
= 365 nm). Decomposition products identified in both reactions were nitrobenzene, pbenzoquinone,
hydroquinone, oxalic acid, and resorcinol. Oxalic acid, hydroquinone, and pbenzoquinone
were identified as intermediate products using HPLC.
At influent concentrations of 10, 1.0, 0.1, and 0.01 mg/L, the GAC adsorption capacities were 250,
140, 74, and 40 mg/g, respectively (Dobbs and Cohen, 1980).
UN1661 Nitroanilines (m-, o-, p-), Hazard Class:
6.1; Labels: 6.1-Poisonous materials.
It also crystallises from acetone. It is freed from o-and m-isomers by zone melting and sublimation. [Beilstein 12 IV 1613.]
A combustible liquid. A strong oxidizer.
Incompatible with strong acids; sulfur, combustibles, organics,
and other easily oxidizable materials. Will accelerate
the burning of combustible materials. If large quantities are
involved in a fire or the combustible material is finely
divided, an explosion may result. Prolonged exposure to
fire or heat may result in an explosion.
Incineration (982℃, 2.0 seconds
minimum) with scrubbing for nitrogen oxides abatement.
Consult with environmental regulatory agencies for
guidance on acceptable disposal practices. Generators of
waste containing this contaminant (≥100 kg/mo) must conform
with EPA regulations governing storage, transportation,
treatment, and waste disposal.
