Basic information Safety Related Supplier
ChemicalBook >  Product Catalog >  API >  Synthetic Anti-infective Drugs >  Antiseptics & Disinfectants Drugs >  2-ETHOXY-6,9-DIAMINOACRIDINE

2-ETHOXY-6,9-DIAMINOACRIDINE

Basic information Safety Related Supplier
2-ETHOXY-6,9-DIAMINOACRIDINE Basic information
2-ETHOXY-6,9-DIAMINOACRIDINE Chemical Properties
  • Melting point:226°
  • Boiling point:396.5°C (rough estimate)
  • Density 1.0966 (rough estimate)
  • refractive index 1.5700 (estimate)
  • storage temp. Sealed in dry,2-8°C
  • pka11.22±0.10(Predicted)
2-ETHOXY-6,9-DIAMINOACRIDINE Usage And Synthesis
  • OriginatorRivanol,Sopharma
  • Manufacturing ProcessA mixture of 250 parts by volume of ethylene glycol, 50 parts by weight of 6- nitro-9-chloro-2-ethoxyacridine (obtained by reaction of 52 parts by weight of 30 nitro-4-ethoxy-diphenylamine-6-carboxylic acid with phosphorous oxychloride), 10 parts by weight of ammonium chloride, and 11 parts by weight of urea were heated to 170°C and stirred for 1 hour at 170°-175°C. Subsequently, the whole was cooled to 100°C, the reaction mixture was introduced into 1000 parts by volume of water, rendered acidic to Congo paper by means of hydrochloric acid and the 6-nitro-9-amino-2-ethoxyacridine precipitated was filtered off. By reduction iron according to Bechamp, 6,9- diamino-2-ethoxy-acridine hydrochloride was obtained with yield of 83% as the yellow needles. The base was prepared by adding an equivalent of NaOH. MP: 124°C.
    In practice it is usually used as lactate.
  • Therapeutic FunctionAntiseptic, Antibacterial
  • Purification MethodsIt crystallises from 50% EtOH or EtOH as orange-yellow crystals. It also crystallises as a monohydrate m 116-118o. It has a pK2 0 of 11.04 in 50% aqueous EtOH. The methiodide is soluble in H2O and has m 332-334o (dec) (from aqueous Me2CO). [Albert & Gledhill J Soc Chem Ind 61 159 1942, Foye et al. J Pharm Sci 57 1795 1968, Albert & Goldacre J Chem Soc 708 1946, Beilstein 22 II 458, 22 III/IV 6679, 22/12 V 243.]
2-ETHOXY-6,9-DIAMINOACRIDINE Preparation Products And Raw materials
2-ETHOXY-6,9-DIAMINOACRIDINE(442-16-0)Related Product Information
2-ETHOXY-6,9-DIAMINOACRIDINESupplierMore
  • Company Name:LGM Pharma
  • Tel:1-(800)-881-8210
  • Email:inquiries@lgmpharma.com
  •  
  • Company Name:Shanghai T&W Pharmaceutical Co., Ltd.
  • Tel:+86 21 61551611
  • Email:
  •  
  • Company Name:Amadis Chemical Company Limited
  • Tel:0086-571-89925085
  • Email:sales@amadischem.com
  •  
  • Company Name:Suzhou Laihui Biotechnology Co., Ltd.
  • Tel:180-13160973
  • Email:rywaybio@gmail.com;info@rywaybio.com
  •  
  • Company Name:Hubei Yangxin Medical Technology Co., Ltd.
  • Tel:18672002673
  • Email:3003335020@qq.com
  •