ChemicalBook > Product Catalog > API > Synthetic Anti-infective Drugs > Antiseptics & Disinfectants Drugs > 2-ETHOXY-6,9-DIAMINOACRIDINE
2-ETHOXY-6,9-DIAMINOACRIDINE Chemical Properties
- Melting point:226°
- Boiling point:396.5°C (rough estimate)
- Density 1.0966 (rough estimate)
- refractive index 1.5700 (estimate)
- storage temp. Sealed in dry,2-8°C
2-ETHOXY-6,9-DIAMINOACRIDINE Usage And Synthesis
- Manufacturing ProcessA mixture of 250 parts by volume of ethylene glycol, 50 parts by weight of 6-
nitro-9-chloro-2-ethoxyacridine (obtained by reaction of 52 parts by weight of
30 nitro-4-ethoxy-diphenylamine-6-carboxylic acid with phosphorous
oxychloride), 10 parts by weight of ammonium chloride, and 11 parts by
weight of urea were heated to 170°C and stirred for 1 hour at 170°-175°C.
Subsequently, the whole was cooled to 100°C, the reaction mixture was
introduced into 1000 parts by volume of water, rendered acidic to Congo
paper by means of hydrochloric acid and the 6-nitro-9-amino-2-ethoxyacridine
precipitated was filtered off. By reduction iron according to Bechamp, 6,9-
diamino-2-ethoxy-acridine hydrochloride was obtained with yield of 83% as
the yellow needles. The base was prepared by adding an equivalent of NaOH.
In practice it is usually used as lactate.
- Therapeutic FunctionAntiseptic, Antibacterial
- Purification MethodsIt crystallises from 50% EtOH or EtOH as orange-yellow crystals. It also crystallises as a monohydrate m 116-118o. It has a pK2 0 of 11.04 in 50% aqueous EtOH. The methiodide is soluble in H2O and has m 332-334o (dec) (from aqueous Me2CO). [Albert & Gledhill J Soc Chem Ind 61 159 1942, Foye et al. J Pharm Sci 57 1795 1968, Albert & Goldacre J Chem Soc 708 1946, Beilstein 22 II 458, 22 III/IV 6679, 22/12 V 243.]
2-ETHOXY-6,9-DIAMINOACRIDINE Preparation Products And Raw materials
- Company Name:LGM Pharma
- Company Name:Shanghai T&W Pharmaceutical Co., Ltd.
- Tel:+86 21 61551611
- Company Name:Amadis Chemical Company Limited
- Company Name:Suzhou Laihui Biotechnology Co., Ltd.
- Company Name:Hubei Yangxin Medical Technology Co., Ltd.