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Ethisterone

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Ethisterone Basic information
Ethisterone Chemical Properties
  • Melting point:263-269 °C (lit.)
  • alpha D23 +23.8° (dioxane); D25 -32.0° (pyridine)
  • Boiling point:392.36°C (rough estimate)
  • Density 1.0697 (rough estimate)
  • refractive index 33 ° (C=1, Pyridine)
  • storage temp. room temp
  • pka13.10±0.60(Predicted)
  • form neat
  • Water Solubility soluble in chloroform, DMSO (0.05 mg/ml), acetone (slightly ), ethanol (<1 mg/ml at 25°C), and water (<1 mg/ml at 25°C).
  • Merck 14,3741
  • BRN 1889895
  • InChIKeyCHNXZKVNWQUJIB-CEGNMAFCSA-N
  • CAS DataBase Reference434-03-7
  • NIST Chemistry ReferenceEthisterone(434-03-7)
Safety Information
  • Hazard Codes Xn,T
  • Risk Statements 40-48-61
  • Safety Statements 22-24/25-45-53
  • RIDADR UN 2811
  • WGK Germany 3
  • RTECS TU5570250
  • HS Code 29372390
MSDS
Ethisterone Usage And Synthesis
  • Chemical PropertiesOff-White Powder
  • OriginatorLutocyclin,Ciba
  • UsesSynthetic progestogen; metabolite of Danazol; intermediate in the synthesis of Spironolactone
  • DefinitionChEBI: A 17beta-hydroxy steroid that is testosterone in which the 17beta hydrogen is replaced by an ethynyl group. Ethisterone was the first orally active progestin and is a metabolite of danazol.
  • Manufacturing Process0.5 part of δ5:6-17-ethinyl-androstendiol-(3:17) is dissolved in 10 parts of dry acetone, the solution is mixed with a solution of 1 part of tertiary aluminum butylate in 40 parts of absolute toluene and the whole is heated to boiling in a reflux apparatus for 21 hours. After the reaction mixture has cooled it is diluted with 100 parts of ether, the solution is washed with dilute mineral acid and with water, dried and the solvent is evaporated. In this manner there is obtained δ5:6-17-ethinyl-androstene-3-one-17-ol (ethisterone); MP: 270°- 272°C; it may be recrystallized from ethyl acetate.
  • Therapeutic FunctionProgestin
Ethisterone Preparation Products And Raw materials
Ethisterone(434-03-7)Related Product Information
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