Oracon,Mead Johnson,US,1965
Dimethisterone-d3 is the labeled analogue of Dimethisterone (D460430), an oral contraceptive steroid.
ChEBI: Dimethisterone is a 3-hydroxy steroid. It has a role as an androgen.
A solution of a Grignard reagent, employing 1-propyne (8 grams) was
prepared. To this reagent there was added the 3,3 ethylenedioxy derivative (4
grams) of 6-α-methylandrost-4-ene-3,17-dione in tetrahydrofuran (100 ml),
and the mixture heated under reflux for 3 hours. After decomposition of the
complex with aqueous ammonium chloride, the product was isolated with
ether and treated with 90% acetic acid (50 ml) for 30 minutes at 100°C. The
product obtained by pouring the mixture into water and extracting with ether
was crystallized from aqueous methanol. 17β-Hydroxy-6α-methyl-17α-(prop-
1-ynyl)androst-4-en-3-one formed plates MP 99° to 102°C.
