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Ethisterone

Ethisterone Structure
Ethisterone
  • CAS No.434-03-7
  • Chemical Name:Ethisterone
  • CBNumber:CB1207877
  • Molecular Formula:C21H28O2
  • Formula Weight:312.45
  • MOL File:434-03-7.mol
Ethisterone Property
  • Melting point: :263-269 °C (lit.)
  • alpha  :D23 +23.8° (dioxane); D25 -32.0° (pyridine)
  • Boiling point: :392.36°C (rough estimate)
  • Density  :1.0697 (rough estimate)
  • refractive index  :33 ° (C=1, Pyridine)
  • storage temp.  :room temp
  • pka :13.10±0.60(Predicted)
  • form  :neat
  • Water Solubility  :soluble in chloroform, DMSO (0.05 mg/ml), acetone (slightly ), ethanol (<1 mg/ml at 25°C), and water (<1 mg/ml at 25°C).
  • Merck  :14,3741
  • BRN  :1889895
  • InChIKey :CHNXZKVNWQUJIB-CEGNMAFCSA-N
  • CAS DataBase Reference :434-03-7
  • FDA UNII :P201BVY1MJ
  • NIST Chemistry Reference :Ethisterone(434-03-7)
Safety
  • Hazard Codes  :Xn,T
  • Risk Statements  :40-48-61
  • Safety Statements  :22-24/25-45-53
  • RIDADR  :UN 2811
  • WGK Germany  :3
  • RTECS  :TU5570250
  • HS Code  :29372390
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H360
  • Precautionary statements P201-P308+P313-P202-P280-P405-P501a
Ethisterone Price More Price(9)
  • Brand: Sigma-Aldrich
  • Product number: 46272
  • Product name : Ethisterone
  • Purity: VETRANAL
  • Packaging: 250mg
  • Price: $41.8
  • Updated: 2018/11/20
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: E1001
  • Product name : Ethisterone
  • Purity: ≥99% (HPLC)
  • Packaging: 25g
  • Price: $211
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: J63580
  • Product name : Ethisterone, 98%
  • Purity: 
  • Packaging: 25g
  • Price: $338
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: J63580
  • Product name : Ethisterone, 98%
  • Purity: 
  • Packaging: 5g
  • Price: $155
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 22893
  • Product name : Ethisterone
  • Purity: ≥95%
  • Packaging: 5g
  • Price: $75
  • Updated: 2021/03/22
  • Buy: Buy

Ethisterone Chemical Properties,Usage,Production

  • Chemical Properties Off-White Powder
  • Originator Lutocyclin,Ciba
  • Uses Synthetic progestogen; metabolite of Danazol; intermediate in the synthesis of Spironolactone
  • Definition ChEBI: A 17beta-hydroxy steroid that is testosterone in which the 17beta hydrogen is replaced by an ethynyl group. Ethisterone was the first orally active progestin and is a metabolite of danazol.
  • Manufacturing Process 0.5 part of δ5:6-17-ethinyl-androstendiol-(3:17) is dissolved in 10 parts of dry acetone, the solution is mixed with a solution of 1 part of tertiary aluminum butylate in 40 parts of absolute toluene and the whole is heated to boiling in a reflux apparatus for 21 hours. After the reaction mixture has cooled it is diluted with 100 parts of ether, the solution is washed with dilute mineral acid and with water, dried and the solvent is evaporated. In this manner there is obtained δ5:6-17-ethinyl-androstene-3-one-17-ol (ethisterone); MP: 270°- 272°C; it may be recrystallized from ethyl acetate.
  • Therapeutic Function Progestin
Ethisterone Preparation Products And Raw materials
Raw materials
Preparation Products
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434-03-7, EthisteroneRelated Search:
  • 4,17ALPHA-PREGNEN-17BETA-OL-20-YN-3-ONE
  • 4,17a-pregnen-17b-ol-20-yn-3-one
  • 4,17A-PREGNEN-17B-OL-20-YNE
  • 4-ANDROSTEN-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE
  • (8R,9S,10R,13S,14S,17R)-17-ETHYNYL-17-HYDROXY-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
  • ANHYDROHYDROXYPROGESTERONE
  • ANHYDROXYPROGESTERONE
  • 17BETA-HYDROXY-4,17ALPHA-PREGNEN-20-YN-3-ONE
  • 17b-hydroxy-4,17a-pregnen-20-yn-3-one
  • (8R,9S,10R,13S,14S,17S)-17-ethynyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
  • Ethisterone, 98%, a progestogen hormone being considered to treat prostate cancer
  • pregneninolo
  • 17A-ETHYNYL-4-ANDROSTEN-17B-OL-3-ONE
  • 17a-ethynyl-17b-hydroxy-4-androsten-3-one
  • 17A-ETHYNYLTESTOSTERONE
  • 17ALPHA-ETHYNYLTESTOSTERONE
  • 17α-Ethynyltestosterone, 17β-Hydroxy-4,17α-pregnen-20-yn-3-one, 4,17α-Pregnen-17β-ol-20-yn-3-one
  • (8R,9S,10R,13S,14S,17R)-17-ETHYNYL-17-HYDROXY-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHY
  • ETHISTERONE(RG)
  • Ethisterone,17α-Ethynyltestosterone, 17β-Hydroxy-4,17α-pregnen-20-yn-3-one, 4,17α-Pregnen-17β-ol-20-yn-3-one
  • ETHISTERONE(RG)(CALL)
  • Ethisterone 0
  • (17α)-17-hydroxy-pregn-4-en-20-yn-3-one
  • ETHINYL TESTOSTERONE
  • ETHISTERONE
  • ETHYNYLTESTOSTERONE
  • ETHYNYLANDROSTENOLONE
  • (17-alpha)-pregn-4-en-20-yn-3-on
  • Gestoral
  • Lucorteum Oral
  • lucorteumoral
  • Lutidon Oral
  • lutidonoral
  • Lutocyclin
  • Lutocyclol
  • Lutocylol
  • Nalutoral
  • NSC-9565
  • Nugestoral
  • Ora-Lutin
  • Pranone
  • Pregn-4-en-20-yn-3-one, 17-hydroxy-, (17alpha)-
  • Pregneninolone
  • Pregnin
  • Primolut C
  • primolutc
  • Prodoxan
  • Prodroxan
  • Produxan
  • Progestab
  • Progestin P
  • progestinp
  • Progestolets
  • Progestoral
  • Prolutol
  • Proluton C
  • 17-alpha-ethinyltestosterone
  • 17alpha-Ethynyl-17beta-hydroxyandrost-4-en-3-one