Basic information Description Reference Safety Related Supplier
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Basic information Description Reference Safety Related Supplier
2'-Hydroxyacetophenone Basic information
2'-Hydroxyacetophenone Chemical Properties
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38-36/38
  • Safety Statements 26-36-37/39
  • WGK Germany 3
  • RTECS AM8575000
  • 8
  • Hazard Note Harmful/Irritant
  • TSCA Yes
  • HS Code 29145000
  • ToxicityLD50 orally in Rabbit: 2127 mg/kg LD50 dermal Rat > 2000 mg/kg
2'-Hydroxyacetophenone Usage And Synthesis
  • DescriptionIt is a typical flavour additive for cherry kernel, cinnamon, rum, tobacco, coumarin, and tropical fruit. Moreover, it can be used as the intermediate or raw material in organic synthesis. Specifically, this chemical may act as the raw material to prepare a Schiff’s base al-alkoxide initiator that facilitates the controlled polymerization of DL-lactide.1 This substance can also function as the effective component in balsamic compounds for fabricating taste modifying compositions.2 Additionally, this chemical has been employed to react with benzoyl chloride for generating 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran, which exhibits good performance for treating cancer and other proliferative diseases such as psoriasis and restenosis.3
  • Reference
    1. Bhaw-Luximon, A.; Jhurry, D.; Spassky, N., Controlled polymerization of DL-lactide using a Schiff's base al-alkoxide initiator derived from 2-hydroxyacetophenone. Polym. Bull. 2000, 44, 31-38.
    2. Johann Wonschick; Clemens M. Putter; Keepe, E., TASTE MODIFYING COMPOSITIONS PCT WO 2016/103183 A1 2016.
    3. Alexander J Bridges; Saltiel, A. R., 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders US Patent US5525625 1996.
  • Chemical Propertiesclear yellow to brown liquid
  • Chemical Properties2-Hydroxyacetophenone has a sweet, heavy floral, herbaceous odor, reminiscent of mown hay or hawthorn
  • OccurrenceReported found in beef, cassia oil, cocoa, cocoa powder, coffee, Jamaican rum, tomato, Scotch whiskey, sherry, tea, mountain papaya, papaya, roasted almond and black choke berry
  • Uses2’Hydroxyacetophenone is a phenolic compound used in the synthesis of potential anti-myobacterial and anticancer agents.
  • PreparationPreparation by Fries rearrangement of phenyl acetate, with Lewis acids
    aluminium chloride.
  • Aroma threshold valuesDetection: 5.5 ppm; aroma characteristics at 2.0%: phenolic, sharp, benzaldehyde, cherry pit, tropical, melon with a tobacco afternote
  • Taste threshold valuesTaste characteristics at 5.0 ppm: naphthyl, cinnamon, cherry pit, coumarin, phenolic, tobacco and honey.
  • Synthesis Reference(s)Tetrahedron Letters, 24, p. 377, 1983 DOI: 10.1016/S0040-4039(00)81412-4
2'-Hydroxyacetophenone Preparation Products And Raw materials
2'-Hydroxyacetophenone(118-93-4)Related Product Information
  • Company Name:Nanjing Apicci Pharmaceutical Technology Co., Ltd. Gold
  • Tel:18061682508
  • Company Name:Nanjing Jingwei Chemical Co., Ltd. Gold
  • Tel:17302588799
  • Tel:13913839793 025-86819862-
  • Company Name:Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. Gold
  • Tel:18678026865 1867-8026865-
  • Company Name:Tianjin Zhongxin Chemtech Co., Ltd.
  • Tel:022-66880623