white to light yellow crystal powde
3-Coumaranone is used in the aurones, [2-benzylidenebenzofuran-3(2H)-ones] by reacting with appropriate aldehyde. It is involved in the condensation reaction with aldehydes in the presence of morpholine acetate to prepare substituted 2-(arylidene)benzofuran-3(ZH)-ones. In Horner-Wadsworth-Emmons reaction, it reacts with diethyl cyanomethylphosphonate to give 3-(cyanomethyl)benzofurans, which is an intermediate in the synthesis of antihyperglycemic agents.
Benzofuran-3(2H)-one undergoes condensation with aldehydes in the presence of morpholine acetate to yield substituted 2-(arylidene)benzofuran-3(ZH)-ones. It undergoes acid- or base-catalyzed condensation with an appropriate aldehyde to yield aurones [2-benzylidenebenzofuran-3(2H)-ones].
At room temperature and pressure, 0.2 mmol of 2-ethynylphenol was dissolved in 1 mL of dichloromethane to obtain a dichloromethane solution of 2-ethynylphenol; then 0.01 mmol of mercury trifluoromethanesulfonate and 0.24 mmol of pyridine-N-oxide were added to the dichloromethane solution of 2-ethynylphenol; after that, it was stirred for 1 hour at room temperature at a stirring rate of 600 r/min, and the reaction produced 3 -benzofuranone, and 24.7 mg of 3-benzofuranone was obtained by silica gel column chromatography in 92.2% yield.
