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4-Hydroxycoumarin

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4-Hydroxycoumarin Basic information
4-Hydroxycoumarin Chemical Properties
  • Melting point:211-213 °C(lit.)
  • Boiling point:228.82°C (rough estimate)
  • Density 1.1734 (rough estimate)
  • refractive index 1.4500 (estimate)
  • storage temp. Store below +30°C.
  • pka4.50±1.00(Predicted)
  • form Liquid
  • color Clear colorless to slightly yellow
  • Water Solubility PRACTICALLY INSOLUBLE
  • BRN 129768
  • InChIKeyVXIXUWQIVKSKSA-UHFFFAOYSA-N
  • CAS DataBase Reference1076-38-6(CAS DataBase Reference)
  • NIST Chemistry Reference4-Hydroxycoumarin(1076-38-6)
  • EPA Substance Registry System2H-1-Benzopyran-2-one, 4-hydroxy- (1076-38-6)
Safety Information
  • Hazard Codes Xn,Xi
  • Risk Statements 22-36/37/38
  • Safety Statements 26-36
  • WGK Germany 3
  • RTECS DJ3100000
  • Hazard Note Irritant
  • TSCA Yes
  • HS Code 29322980
MSDS
4-Hydroxycoumarin Usage And Synthesis
  • Chemical PropertiesYellow powder or chunks
  • Uses4-Hydroxy Coumarin is a plant derived antioxidant, protecting against lipid peroxidation, as well as a potential inhibitor of HIV-1 Integrase.
  • Uses4-Hydroxycoumarin may be regarded as a phenylenetetronic acid , and like tetronic acid forms condensation products with aldehydes.
    RuCl3.nH2O catalyzed synthesis of biscoumarins
    Synthesis of biscoumarin derivatives by the reaction of aldehydes and 4-hydroxycoumarin using ruthenium(III) chloride hydrate as a versatile homogeneous catalyst.
  • DefinitionChEBI: A hydroxycoumarin that is coumarin in which the hydrogen at position 4 is replaced by a hydroxy group.
  • Synthesis Reference(s)The Journal of Organic Chemistry, 25, p. 677, 1960 DOI: 10.1021/jo01074a630
  • Purification MethodsCrystallise 4-hydroxycoumarin from water and dry it in a vacuum desiccator over pKEst Sicapent. [Beilstein 18/1 V 378.]
4-Hydroxycoumarin Preparation Products And Raw materials
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