ChemicalBook > Product Catalog > Pharmaceutical intermediates > Heterocyclic compound > Pyran compounds > 4-Hydroxycoumarin
4-Hydroxycoumarin
- Product Name:4-Hydroxycoumarin
- CAS:1076-38-6
- MF:C9H6O3
- MW:162.14
- EINECS:214-060-2
- Mol File:1076-38-6.mol
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4-Hydroxycoumarin Chemical Properties
- Melting point:211-213 °C(lit.)
- Boiling point:228.82°C (rough estimate)
- Density 1.1734 (rough estimate)
- refractive index 1.4500 (estimate)
- storage temp. Store below +30°C.
- pka4.50±1.00(Predicted)
- form Liquid
- color Clear colorless to slightly yellow
- Water Solubility PRACTICALLY INSOLUBLE
- BRN 129768
- InChIKeyVXIXUWQIVKSKSA-UHFFFAOYSA-N
- CAS DataBase Reference1076-38-6(CAS DataBase Reference)
- NIST Chemistry Reference4-Hydroxycoumarin(1076-38-6)
- EPA Substance Registry System2H-1-Benzopyran-2-one, 4-hydroxy- (1076-38-6)
- Hazard Codes Xn,Xi
- Risk Statements 22-36/37/38
- Safety Statements 26-36
- WGK Germany 3
- RTECS DJ3100000
- Hazard Note Irritant
- TSCA Yes
- HS Code 29322980
- Language:EnglishProvider:4-Hydroxy-1-benzopyran-2-one
- Language:EnglishProvider:SigmaAldrich
- Language:EnglishProvider:ACROS
- Language:EnglishProvider:ALFA
4-Hydroxycoumarin Usage And Synthesis
- Chemical PropertiesYellow powder or chunks
- Uses4-Hydroxy Coumarin is a plant derived antioxidant, protecting against lipid peroxidation, as well as a potential inhibitor of HIV-1 Integrase.
- Uses4-Hydroxycoumarin may be regarded as a phenylenetetronic acid , and like tetronic acid forms condensation products with aldehydes.
Synthesis of biscoumarin derivatives by the reaction of aldehydes and 4-hydroxycoumarin using ruthenium(III) chloride hydrate as a versatile homogeneous catalyst. - DefinitionChEBI: A hydroxycoumarin that is coumarin in which the hydrogen at position 4 is replaced by a hydroxy group.
- Synthesis Reference(s)The Journal of Organic Chemistry, 25, p. 677, 1960 DOI: 10.1021/jo01074a630
- Purification MethodsCrystallise 4-hydroxycoumarin from water and dry it in a vacuum desiccator over pKEst Sicapent. [Beilstein 18/1 V 378.]
4-Hydroxycoumarin Preparation Products And Raw materials
- Preparation ProductsWarfarinBromadioloneBrodifacoum4-Hydroxycinnamic acidFlocoumafenCoumatetralylACENOCOUMAROLreversible temperature indication paint (III)
- Raw materialsSodium hydroxideHydrochloric acidEthyl acetateSodium sulfateBenzeneSodium hydride Sodium acetateMineral oilDiethyl carbonate2'-HydroxyacetophenoneAcetoxyacetic acidO-ACETYLSALICYLOYL CHLORIDEACETYLSALICYLIC ACID METHYL ESTER
- r-(+)-3-acetonybenzyl)-4-hydroxycoumarin,(S)-3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin Warfarin s-(-)-3-acetonybenzyl)-4-hydroxycoumarin 4,4'-(Disulfanediyl)bis(2,6-di-tert-butylphenol) (S)-8-Hydroxy Warfarin 6-HYDROXYWARFARIN (R)-8-HYDROXY WARFARIN (R)-6-Hydroxy Warfarin 3-(o-Hydroxyphenyl)-5-phenyl-2-cyclohexen-1-one Benzalacetone 3-[α-(2-Hydroxypropyl)benzyl]-4-hydroxycouMarin (R)-7-Hydroxy Warfarin 7-HYDROXYWARFARIN (S)-6-Hydroxy Warfarin Warfarin Impurity 1 8-HYDROXYWARFARIN 2,6-Di-tert-butyl-4-mercaptophenol 7-HYDROXYWARFARIN
4-HydroxycoumarinSupplierMore
- Company Name:Luotian Xinpusheng Pharmaceutical Co., Ltd. Gold
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- Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.
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