2-Hydroxyacetophenone

slightly yellow to orange powder

2-Hydroxyacetophenone can be used as a starting material for the synthesis of:

• Enantioselective 1R-phenyl-1,2-ethanediol in the presence of a rhodium(III) catalyst by asymmetric transfer hydrogenation.
• Copper(II) complexes of 2-hydroxyacetophenone N-substituted thiosemicarbazones.
• Chromium, molybdenum, and ruthenium complexes of 2-hydroxyacetophenone Schiff bases.
• 2-Hydroxyacetophenone-aroyl hydrazone derivatives for inhibition of copper corrosion in nitric acid.

2-Hydroxyacetophenone can be used to produce 2-hydroxy-1-phenyl-ethanone-(1)-oxime by heating. It is used as pharmaceutical intermediate.

ChEBI: 2-hydroxyacetophenone is a monohydroxyacetophenone that is acetophenone in which one of the methyl hydrogens has been replaced by a hydroxy group. It is a primary alcohol, a primary alpha-hydroxy ketone and a monohydroxyacetophenone.

Add 20 mmol of 48% hydrobromic acid to a 500 mL three-necked flask containing 20 mmol of styrene and 100 mL of water at room temperature, and slowly add 200 mmol of . 30% hydrogen peroxide, control the drip time for 30min, stir at room temperature for 30min, heat up to 80 , the reaction was 10h. C, the reaction was carried out for 10 h. The organic and aqueous phases were separated by standing. The organic phase containing 2-bromoacetophenone was added to a reactor containing 150 mL of water . The organic phase containing 2-bromoacetophenone was added to a reactor containing 150 mL of water , and hydrolyzed completely under the promotion of microwave, and the organic and aqueous phases were separated by standing to obtain a solution of 2-hydroxyacetophenone.

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