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Rutin

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Rutin Basic information
  • Product Name:Rutin
  • CAS:153-18-4
  • MF:C27H30O16
  • MW:610.52
  • EINECS:205-814-1
  • Mol File:153-18-4.mol
Rutin Chemical Properties
  • Melting point:195 °C (dec.)(lit.)
  • alpha D23 +13.82° (ethanol); D23 -39.43° (pyridine)
  • Boiling point:576.13°C (rough estimate)
  • Density 1.3881 (rough estimate)
  • refractive index 1.7650 (estimate)
  • storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
  • solubility pyridine: 50 mg/mL
  • form powder
  • pka6.17±0.40(Predicted)
  • Colour Index 75730
  • color yellow to green
  • Water Solubility 12.5 g/100 mL
  • Merck 8304
  • CAS DataBase Reference153-18-4(CAS DataBase Reference)
  • NIST Chemistry ReferenceFlavone-3-rutinoside, 3,3',4',5,7-pentahydroxy(153-18-4)
  • EPA Substance Registry SystemRutin (153-18-4)
Safety Information
  • Hazard Codes Xn,Xi
  • Risk Statements 22-36/37/38
  • Safety Statements 24/25-36-26
  • WGK Germany 3
  • RTECS VM2975000
  • 8
  • HS Code 29381000
  • ToxicityLD50 i.v. in mice: 950 mg/kg (propylene glycol soln) (Harrison)
MSDS
Rutin Usage And Synthesis
  • Chemical PropertiesPale-Yellow Crystalline Solid
  • UsesFound in many plants, especially the buckwheat plant. Identity with Ilixanthin. Capillary protectant. Rutin is colored brown by tobacco enzyme under experimental conditions.
  • Usesantidiabetic, dipeptidyl peptidase–4 inhibitor
  • UsesFor nutritional product
  • Usesrutin is described as helping to tighten and strengthen skin capillaries, and as such it could help prevent a couperose condition. It also demonstrates anti-oxidant properties. Rutin is a flavonoid found in rue leaves, buckwheat, and other plants.
  • DefinitionChEBI: A rutinoside that is quercetin with the hydroxy group at position C-3 substituted with glucose and rhamnose sugar groups.
  • Purification MethodsThe vitamin crystallises from MeOH or water/EtOH, dry it in air, then dry it further for several hours at 110o or in high vacuum at 120o. It forms yellow crystals from EtOH/Me2CO/H2O (2:1:1). It has also been purified by passing (0.5g) through a Kieselgel column (30 x 5cm) with EtOAc/MeOH/H2O (100:20:15), and after 750mL have passed through, the yellow fraction of 250mL gives the glycoside (0.3g) on evaporation. [H.rhammer et al. Chem Ber 101 1183 1968, Marini-Bettòlo Gazz Chim Ital 80 631 1950, Beilstein 18/5 V 519.]
Rutin Preparation Products And Raw materials
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