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Candesartan Basic information
Candesartan Chemical Properties
  • Melting point:183-185°C
  • Boiling point:754.8±70.0 °C(Predicted)
  • Density 1.41±0.1 g/cm3(Predicted)
  • RTECS DD6671000
  • storage temp. Inert atmosphere,Store in freezer, under -20°C
  • pka2.06±0.10(Predicted)
  • Water Solubility Soluble in ethyl acetate, methanol, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).
  • CAS DataBase Reference139481-59-7(CAS DataBase Reference)
Safety Information
Candesartan Usage And Synthesis
  • Chemical PropertiesCrystalline Solid
  • UsesAn angiotensin II type-1 receptor antagonist. Used in treatment of congestive heart failure. Antihypertensive
  • Usesantihypertensive, angiotensin II inhibitor
  • DefinitionChEBI: A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin eceptor antagonist used for the treatment of hypertension.
  • brand nameAtacand (AstraZeneca).
  • General DescriptionCandesartan, (+)-1-[[(cyclohexyloxy)carbonyl]-oxy]ethyl 2- ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate(Atacand), like losartan, possesses the acidic tetrazole system,which most likely plays a role in binding to the angiotensin IIreceptor similarly to the acidic groups of angiotensin II. Also,the imidazole system has been replaced with a benzimidazolepossessing an ester at position. This ester must be hydrolyzedto the free acid. Fortunately, this conversion takesplace fairly easily because of the carbonate in the ester sidechain. This facilitates hydrolysis of the ester so much thatconversion to the free acid takes place during absorption fromthe gastrointestinal tract.
Candesartan Preparation Products And Raw materials
Candesartan(139481-59-7)Related Product Information
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