GENERAL STEPS: Amide (0.5 mmol), PEPPSI catalyst (0.025 mmol, 5 mol%), and K2CO3 (2 eq.) were added to a 20 mL Schlenk tube under nitrogen protection, followed by degassing of the system and replacement with nitrogen three times. Methyl tert-butyl ether (MTBE, 6.0 mL) was added via syringe as solvent, followed by 0.75 mL (1.5 eq.) of borane solution (1 M in THF, commercially available or prepared in situ by borohydride reaction of olefins). The reaction mixture was stirred at room temperature in a nitrogen atmosphere for 24 hours. Upon completion of the reaction, the reaction was quenched with ice water (5 mL) and extracted with MTBE (2 x 5 mL). The organic phases were combined and dried with anhydrous Na2SO4. After filtration, the solvent was removed by rotary evaporator to obtain the crude product. The crude product was purified by rapid column chromatography on silica gel, and the eluent was a mixed petroleum ether/ethyl acetate solvent.
![4-Chloro-N-methyl-N-[(4-methylphenyl)sulfonyl]benzamide](/CAS/20210305/GIF/1445317-56-5.gif)
