Propiophenone Chemical Properties
- Melting point:17-19 °C(lit.)
- Boiling point:218 °C(lit.)
- Density 1.009 g/mL at 25 °C(lit.)
- vapor pressure 1 mm Hg ( 50 °C)
- refractive index n
- FEMA 3469 | PROPIOPHENONE
- Flash point:190 °F
- storage temp. Store below +30°C.
- solubility Difficult to mix.
- form Liquid
- color Clear colorless to light yellow
- Water Solubility INSOLUBLE
- Merck 14,7830
- JECFA Number824
- BRN 606215
- Stability:Stable. Incompatible with strong oxidizing agents, strong bases.
- CAS DataBase Reference93-55-0(CAS DataBase Reference)
- NIST Chemistry Reference1-Propanone, 1-phenyl-(93-55-0)
- EPA Substance Registry SystemPropiophenone (93-55-0)
Propiophenone Usage And Synthesis
- DescriptionPropiophenone belongs to the family of acetophenones, which is present in some certain cheese, coffee and coffee products, tea and roasted nuts with sweet-smelling odor. It is wisely used as an intermediate in the preparation of other organic compounds, such as synthetic aryl alkenes, like cinnamic acids. It is also a useful intermediate for pharmaceuticals production, such as ephedrine, propiophenone derivatives (cathinone and methcathinone), and especially for the preparation of nervous system drugs (anxiolytic and hypnotic drugs). Besides, due to its naturally pleasant flowery odor, propiophenone can be used as a component in some perfumes.
- Chemical Propertiescolourless to light yellow liquid
- Chemical PropertiesPropiophenone has a strong, flowery odor.
- OccurrenceReported found in coffee, roasted filberts, roasted peanuts and roasted green tea. Also reported found in Camembert cheese, black tea, roasted macadamia nut, tamarind, dried bonito, cherimoya and sapodilla fruit.
- UsesPropiophenone is an aryl ketone used in the preparation of pharmaceutical and organic compounds. Propiophenone is used in perfumes as well as in the preparation of neurochemical compounds such as ephe drines.
- UsesIn perfumery; in the synthesis of ephedrine and related Compounds.
- UsesIntermediates of Liquid Crystals
- DefinitionChEBI: An aromatic ketone in which the two substituents on the carbonyl C atom are phenyl and ethyl.
- Production MethodsPropiophenone is produced by the Friedel–Crafts acylation of benzene with propionic acid chloride in the presence of aluminum chloride. It may also be produced by the reaction of benzoic acid and propionic acid using a calcium acetate– aluminum oxide catalyst.
- Synthesis Reference(s)The Journal of Organic Chemistry, 60, p. 2430, 1995 DOI: 10.1021/jo00113a024
Tetrahedron Letters, 30, p. 4819, 1989 DOI: 10.1016/S0040-4039(01)80517-7
- Safety ProfilePoison by intraperitoneal route. Moderately toxic by subcutaneous route. Mildly toxic by ingestion and skin contact. A skin and eye irritant. A flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.
Propiophenone Preparation Products And Raw materials
- Raw materialsEthyl acetateAluminium chlorideBenzeneacetonitrileAluminium chloride hexahydratePropionic acidPhenylacetic acidPropionyl chloride
- Preparation ProductsFluoxetinefluorescent brightener 3113-BENZOYL PROPIOPHENONEEthyl 3-methyl-3-phenylglycidateD/L-AMPHETAMINE HYDROCHLORIDEBipariden(S)-MEPHENYTOINAclarubicinPravastatinD-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL1-Phenyl-1-propanolnitrilon whitening agent AD
- 4,4'-DIBROMOBENZIL 3-(2-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 2-BROMO-2-PHENYLACETOPHENONE 4'-Fluoropropiophenone 4'-BROMOVALEROPHENONE METHYL 4-FLUOROBENZOYLACETATE Propiophenone Ethanol Ethyl acetate Ethyl acrylate 4'-Hydroxypropiophenone Phenylhydrazine Ethylparaben 4'-Chloropropiophenone Diethyl ether PHENYL VALERATE Citric acid monohydrate 3-Pentanone