Some side effects of Norethindrone can be serious, though uncommon. If you experience any of the following symptoms, it's important to contact your doctor immediately: loss of vision, blurred vision, double vision, bulging eyes, migraine headache, pain, warmth, or heaviness in the back of the lower leg, shortness of breath, coughing up blood, sudden sharp or crushing chest pain, heaviness in chest, slow or difficult speech, dizziness or faintness, weakness or numbness of an arm or leg, swelling of the arms, hands, feet, ankles, or lower legs, yellowing of the skin or eyes, depression, mood swings, missed periods, sudden, severe pain in the abdomen (area between the chest and waist), hives, rash, itching, difficulty breathing, or swallowing. Additionally, Norethindrone may cause other side effects not listed here, so it's essential to reach out to your doctor if you experience any unusual problems while taking this medication.