세프티족심 나트륨

한글명:세프티족심 나트륨

카스 번호68401-82-1

상품명:Ceftizoxime sodium

CBNumberCB7452781

분자식C13H14N5NaO5S2

포뮬러 무게407.39

MOL 파일68401-82-1.mol

동의어(한글)

세프티족심나트륨

세프티족심나트륨(CEFTIZOXIMESODIUM)

화학적 성질

녹는점	227℃
RTECS 번호	XI0368000
저장 조건	-20°C
용해도	DMSO: 용해성1mg/mL
물리적 상태	고체
물리적 상태	단단한 모양
색상	흰색에서 희미한 노란색까지
수용성	물에 용해됨
안정성	솔루션이 불안정함
CAS 데이터베이스	68401-82-1(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

36/37/38

안전지침서

WGK 독일

독성

LD50 in mice, rats (mg/kg): ~6000 i.v. (Fukuhara)

NFPA 704:

	0
2		0

그림문자(GHS)

세프티족심 나트륨 화학적 특성, 용도, 생산

개요
Ceftizoxime was synthesized by Fujisawa Pharmaceutical Industries in 1979. It possesses the (iminothiazolyl)methoxyiminomethyl group at the 7 position of the cephem nucleus, but there is no side chain at the 3 position. The compound shows excellent activity against gram-positive and gram-negative bacteria, behavior similar to that of cefotaxime. Unlike cefotaxime, however, it is not metabolized in vivo.
화학적 성질
Cefotaxime Sodium is white, white or light yellow crystalline powder; odorless; insoluble in organic solvents but soluble in water. The 10% solution has a pH of 4.5 to 6.5. Dilute solution is colorless or yellowish while high-concentration solution is grayish yellow. Dark yellow or brown color indicates that the drug has been deteriorated. The aqueous solution can be stored at 5 ℃ for 1 week.
용도
Antibacterial.
정의
ChEBI: The sodium salt of ceftizoxime.
Clinical Use
Ceftizoxime (Cefizox) is a third-generation cephalosporinthat was introduced in 1984. This β-lactamase–resistant agentexhibits excellent activity against the Enterobacteriaceae,especially E. coli, K. pneumoniae, E. cloacae, Enterobacteraerogenes, indole-positive and indole-negative Proteus spp.,and S. marcescens. Ceftizoxime is claimed to be more activethan cefoxitin against B. fragilis. It is also very active againstGram-positive bacteria. Its activity against P. aeruginosa issomewhat variable and lower than that of either cefotaxime orcefoperazone.
Ceftizoxime is not metabolized in vivo. It is excretedlargely unchanged in the urine. Adequate levels of the drugare achieved in the cerebrospinal fluid for the treatment ofGram-negative or Gram-positive bacterial meningitis. It mustbe administered on a thrice-daily dosing schedule because ofits relatively short half-life. Ceftizoxime sodium is very stablein the dry state. Solutions maintain potency for up to 24hours at room temperature and 10 days when refrigerated.

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