7-아미노세팔로스포란산

한글명:7-아미노세팔로스포란산

카스 번호957-68-6

상품명:7-Aminocephalosporanic acid

CBNumberCB8344119

분자식C10H12N2O5S

포뮬러 무게272.28

MOL 파일957-68-6.mol

동의어(한글)

7-아미노세팔로스포란산

화학적 성질

녹는점	>300 °C (lit.)
알파	94 º (c=0.5, KH2PO4, PH 7)
끓는 점	560.6±50.0 °C(Predicted)
밀도	1.4667 (rough estimate)
증기압	0Pa at 20℃
굴절률	1.5650 (estimate)
저장 조건	2-8°C
용해도	DMSO(아주 약간 용해됨, 가열됨)
산도 계수 (pKa)	2.59±0.50(Predicted)
물리적 상태	결정성 분말
색상	미색부터 베이지까지
optical activity	[α]19/D +90°, c = 0.5 in KH2PO4/trace NaOH
수용성	409.6mg/L(22.99ºC)
Merck	14,434
BRN	622638
안정성	흡습성
InChIKey	HSHGZXNAXBPPDL-HZGVNTEJSA-N
LogP	-3.4 at 20℃
CAS 데이터베이스	957-68-6(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

Xn,Xi

위험 카페고리 넘버

42/43-36/37/38-20/21/22

안전지침서

22-36/37-24/25-36-26

WGK 독일

HS 번호

29349960

NFPA 704:

	1
2		0

그림문자(GHS)

7-아미노세팔로스포란산 MSDS

7-아미노세팔로스포란산 화학적 특성, 용도, 생산

개요
The abbreviation for 7-aminocephalosporanic acid is 7-ACA. It is a white or almost white crystalline powder and serves as a crucial nucleus in the production of cephalosporin antibiotics. By utilizing chemical transformations at positions 7 and 3 of the nucleus, numerous cephalosporins can be synthesized, including cefazolin sodium, cefotaxime sodium, ceftriaxone sodium, cefoperazone sodium, sodium ceftazidime, and cefuroxime sodium.
Cephalosporin antibiotics (Cephalosporins) are a cluster of broad-spectrum semisynthetic antibiotics, they all contain the nucleus of 7-aminocephalosporanic acid (7-ACA), with different groups in the 3 and 7 carbon atoms, forming various cephalosporins with different antibacterial activity and pharmacokinetic characteristics. Cephalosporin antibiotics have broad antibacterial spectrum,strong antibacterial effect, and fewer allergic reactions, and only part of the cross allergic with penicillin and they have varying degrees of stability on the β-lactamase . Cephalosporins have fast development, and many families, they are divided into four generation cephalosporins according to the anti-microbial dynamic "generations" .
They are the same as penicillin, cephalosporins contain β lactam ring , which is necessary to achieve antibacterial efficacy. But penicillins are 6-amino penicillin acid (6-aminopenicillanic acid, 6-APA) derivatives, and cephalosporins nucleus is 7-aminocephalosporanic acid (7-aminocephalosporamic acid, 7-ACA), the latter is from cephalosporin C, it is a fermentation product of Cephalosporium acremonium.
7-aminocephalosporanic acid has a dihydro-thiazine ring (A) and aβ-lactam ring (B), it has a resistant effect on the class of staphylococcus aureus penicillinase. Modifying this nucleus with different side chains can form the entire series of cephalosporin antibiotics. Modifying β-lactam bit 7 (R1), can make antimicrobial efficacy and stability within the β-lactamase change. At 3 bit on-dihydro-thiazine ring substitution (R2), the influence of effect on drug metabolism and pharmacokinetic properties is more staggering than that of antibacterial effect.
Cephamycins are associated with cephalosporin C in chemical structure, the main difference is that they have a 7-α-methoxy group (R3), so that the stability to certain β-lactamase is improved . Cephalosporin is a derivative cephalosporin C which is produced by Streptomyces . Cefotetan is an semi-synthetic derivative of organic mycin G, it is a product of Streptomyces organonensis. Cefmetazole is a semi-synthetic product of 7-aminocephalosporanic acid.

Figure 1 the chemical structure of the 7-aminocephalosporanic acid
화학적 성질
Off-white to beige crystalline powder
정의
ChEBI: 7-Aminocephalosporanic acid is the alpha,beta-unsaturated monocarboxylic acid that is the active nucleus for the synthesis of cephalosporins and intermediates. It is functionally related to a cephalosporanic acid. It is a tautomer of a 7beta-aminocephalosporanic acid zwitterion.
제조 방법
The synthesis of 7-Aminocephalosporanic acid involves esterification of semi-synthetic cephalosporin-cephalosporin C with trimethylchlorosilane, followed by phosphorus pentachloride chloride and butanol etherifying. The final product is obtained through hydrolysis. The yield from cephalosporin C sodium to 7-ACA is approximately 50%.
DOI: 10.3390/jof8050450
일반 설명
The chemical class of 7-aminocephalosporanic acid is Beta-Lactams. This class includes several antibiotic families, such as penicillins, cephalosporins, carbapenems, and monobactams. The Beta-lactam ring is part of the core structure of these families, which is why they are also referred to as Beta-lactam antibiotics.

7-아미노세팔로스포란산 준비 용품 및 원자재

7-아미노세팔로스포란산 공급 업체

7-아미노세팔로스포란산 관련 검색

Send Inquriy