세포탁심 나트륨

한글명:세포탁심 나트륨

카스 번호64485-93-4

상품명:Cefotaxime sodium

CBNumberCB2197478

분자식C16H18N5NaO7S2

포뮬러 무게479.46

MOL 파일64485-93-4.mol

동의어(한글)

세포탁심나트륨

세포탁심나트륨(CEFOTAXIMESODIUM)

화학적 성질

녹는점	162-163 C
알파	D20 +55±2° (c = 0.8 in water)
굴절률	61 ° (C=1, H2O)
저장 조건	Keep in dark place,Inert atmosphere,2-8°C
용해도	H₂O: pH 4.3-6.2의 수용액은 2-8 ℃에서 최대 3주 동안 안정합니다.
물리적 상태	가루
색상	흰색에서 노란색으로
수소이온지수(pH)	pH(100g/l, 25℃) : 4.5～6.5
수용성	물에 용해됩니다.
Merck	14,1933
BRN	5711411
안정성	안정적인. 강한 산화제와 호환되지 않습니다.

위험 및 안전 성명

위험품 표기	Xn,Xi
위험 카페고리 넘버	42/43
안전지침서	22-36/37-60-45-37-24
WGK 독일	2
RTECS 번호	XI0250000
HS 번호	29419000

그림문자(GHS)

세포탁심 나트륨 화학적 특성, 용도, 생산

개요
Cefotaxime was synthesized by Hoechst and Roussel-Uclaf in 1977. It was the first derivative of cephalosporin to introduce the methoxyimino and aminothiazole groups at the 7 position of the cephem nucleus. Although it shows unexpectedly low oral absorption, its excellent activity against a wide range of gram-positive and gram-negative organisms, including Serratia, Enterobacter, Citrobacter, and anaerobes, guided research and development of the newer synthetic cephems, the so-called thirdgeneration cephalosporins.
화학적 성질
White to pale yellow crystalline powder
용도
Cefotaxime sodium salt acts as a beta-lactamase resistant antibiotic. It is used as an effective antibacterial against gram-negative bacteria, with the notable exception of pseudomonas and penicillin-resistant strains of streptococcus pneumoniae. It is used to treat infections of the bones, joints, skin, respiratory tract and blood stream.
정의
ChEBI: A cephalosporin organic sodium salt having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups.
일반 설명
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Clinical Use
Cefotaxime (Claforan) was the first third-generationcephalosporin to be introduced. It possesses excellentbroad-spectrum activity against Gram-positive and Gramnegativeaerobic and anaerobic bacteria. It is more activethan moxalactam against Gram-positive organisms. Manyβ-lactamase–producing bacterial strains are sensitive to cefotaxime,including N. gonorrhoeae, Klebsiella spp., H. influenzae,S. aureus, and E. cloacae. Some, but not all,Pseudomonas strains are sensitive. Enterococci and Listeriamonocytogenes are resistant.
The syn-isomer of cefotaxime is significantly more activethan the anti-isomer against β-lactamase–producing bacteria.This potency difference is, in part, because of greaterresistance of the syn-isomer to the action of β-lactamases.The higher affinity of the syn-isomer for PBPs, however,may also be a factor.
Cefotaxime is metabolized in part to the less active desacetylmetabolite. Approximately 20% of the metaboliteand 25% of the parent drug are excreted in the urine. Theparent drug reaches the cerebrospinal fluid in sufficient concentrationto be effective in the treatment of meningitis.Solutions of cefotaxime sodium should be used within 24hours. If stored, they should be refrigerated. Refrigerated solutionsmaintain potency up to 10 days.

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