디클로페낙 나트륨

한글명:디클로페낙 나트륨

카스 번호15307-79-6

상품명:Diclofenac sodium

CBNumberCB5474464

분자식C14H10Cl2NNaO2

포뮬러 무게318.13

MOL 파일15307-79-6.mol

동의어(한글)

디클로페낙나트륨

디클로페낙나트륨(DICLOFENACSODIUM)

화학적 성질

녹는점	288-290°C
밀도	0.781 g/cm3
저장 조건	room temp
용해도	H₂O: 50 mg/mL
물리적 상태	White solid
산도 계수 (pKa)	4(at 25℃)
색상	White to Almost white
수용성	Soluble in water to 50mg/ml.
Merck	14,3081
안정성	Stable.
InChIKey	KPHWPUGNDIVLNH-UHFFFAOYSA-M
CAS 데이터베이스	15307-79-6(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기	T,Xi
위험 카페고리 넘버	25-36/37/38-63
안전지침서	22-36/37-45-36-26-60-20
유엔번호(UN No.)	UN 2811 6.1/PG 3
WGK 독일	3
RTECS 번호	AG6330000
위험 등급	6.1(b)
포장분류	III
HS 번호	29224999
독성	LD50 in mice, rats (mg/kg): ~390, 150 orally (Krupp)

그림문자(GHS)

디클로페낙 나트륨 MSDS

디클로페낙 나트륨 화학적 특성, 용도, 생산

개요
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC₅₀s = 0.9-2.7 and 1.5-20 μM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester and diclofenac amide . Diclofenac inhibits release of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) induced by A23187 in isolated rat peritoneal neutrophils and macrophages (IC₅₀s = 60 and 10 μM, respectively). Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats. Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
화학적 성질
Off-White Crystalline Solid
용도
Diclofenac sodium is a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. Oxidation of diclofenac sodium produces the metabolite 4'-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.
정의
ChEBI: Diclofenac sodium is the sodium salt of diclofenac. It contains a diclofenac(1-).
World Health Organization (WHO)
The World Health Organization currently has no information to suggest that diclofenac is less safe than other widely available non-steroidal antiinflammatory substances of this type, or that children are particularly liable to react adversely. It is registered in many countries in several dosage forms, including a 12.5 mg suppository indicated for juvenile arthritis.
일반 설명
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Diclofenac is a derivative of benzeneacetic acid. It is categorized under the class of non-steroidal anti-inflammatory drugs (NSAIDs). It shows inflammatory, analgesic and antipyretic activities.
Clinical Use
Diclofenac sodium is indicated for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.

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