비타민 E

한글명:비타민 E

카스 번호2074-53-5

상품명:Vitamin E

CBNumberCB1275359

분자식C29H50O2

포뮬러 무게430.71

MOL 파일2074-53-5.mol

동의어(한글)

비타민E

화학적 성질

끓는 점	485.9±0.0 °C(Predicted)
밀도	0.93
저장 조건	Store at -20°C,protect from light
용해도	Ethanol: 50 mg/mL (116.09 mM); DMSO: 16.11 mg/mL (37.40 mM)
산도 계수 (pKa)	11.40±0.40(Predicted)
CAS 데이터베이스	2074-53-5

그림문자(GHS)

비타민 E 화학적 특성, 용도, 생산

순도시험

(1) 굴절률 : 이 품목의 굴절률 은 1.503～1.507이어야 한다.
  (2) 용상 : 이 품목 0.1g을 무수알콜 10mL에 녹일 때, 그 액은 징명하여야 한다.
  (3) 비흡광도 : 이 품목 10mg을 무수알콜에 녹여 200mL로 하고 액층의 길이 1cm의 측정셀로 파장 292nm에서 흡광도를 측정할 때, ＝71～76이어야 한다.
  (4) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.
  (5) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.
확인시험

이 품목 10mg에 무수에탄올 10mL를 가하여 녹이고 질산 2mL를 가하여 75℃에서 15분간 가열하면 액은 적～등색을 나타낸다.
정량법

이 품목 50mg을 정밀히 달아 황산에탄올용액(3→200) 100mL를 가하여 녹이고, 물 20mL를 가하여 0.01N 황산제이세륨암모늄용액으로 잘 흔들어 섞으면서 적정한다(지시약 : 디페닐아민시액 2방울). 다만, 조작은 직사광선을 피하여 될 수 있는 대로 어두운 곳에서 행하고, 적정속도는 10초간에 25방울로 한다. 종말점은 액의 청자색이 10초간 지속할 때로 한다. 따로 같은 방법으로 공시험을 하여 보정한다.
0.01N 황산제이세륨암모늄용액 1mL ＝ 2.154mg C₂₉H₅₀O₂
강열잔류물

이 품목의 강열잔류물은 0.1% 이하이어야 한다.
물리적 성질
Vitamin E has demonstrated some success in the treatment of yellow nail syndrome when taken orally (600 EU to 1200 EU daily) for several months. Topically-applied vitamin E has also shown significant improvement in symptoms of yellow nail syndrome, as well as increased nail growth rates after six months.
용도
Vitamin E supplement.
Indications
Vitamin E is a potent antioxidant that is capable of protecting polyunsaturated fatty acids from oxidative breakdown.This vitamin also functions to enhance vitamin A use.Although several other physiological actions have been suggested, to date no unifying concept exists to explain these actions. Vitamin E (α-tocopherol) is found in a variety of foodstuffs, the richest sources being plant oils, including wheat germ and rice, and the lipids of green leaves.
benefits
Vitamin E is a fat-soluble nutrient found in many foods. It is the most abundant antioxidant in the skin and the most important lipid-soluble, membrane-bound antioxidant in the body. The body also needs vitamin E to boost its immune system so that it can fight off invading bacteria and viruses. It helps to widen blood vessels and keep blood from clotting within them. In addition, cells use vitamin E to interact with each other and to carry out many important functions.
Clinical Use
Deficiency of vitamin E is characterized by low serum tocopherol levels and a positive hydrogen peroxide hemolysis test.This deficiency is believed to occur in patients with biliary, pancreatic, or intestinal disease that is characterized by excessive steatorrhea. Premature infants with a high intake of fatty acids exhibit a deficiency syndrome characterized by edema, anemia, and low tocopherol levels.This condition is reversed by giving vitamin E.
부작용
Prolonged administration of large dosages of vitamin E may result in muscle weakness, fatigue, headache, and nausea.This toxicity can be reversed by discontinuing the large-dose supplementation.
Toxicology
α-Tocopherol is known as vitamin E and exists in many kind of plants, especially in lettuce and alfalfa. Its color changes from yellow to dark brown when exposed to sunlight. Natural vegetable oils are not readily oxidized due to the presence of tocopherol. During refining processes, however, tocopherol may be removed from oils; consequently, refined vegetable oils can become unstable toward oxidation. In one experiment, vitamin E appeared to be relatively innocuous, having been given to patients for months both orally and parenterally at a dosage level of 300 mg/day without any observed ill effects. However, in another experiment, 6 out of 13 patients given similar doses complained of headache, nausea, fatigue, dizziness, and blurred vision. Although the chronic toxicity of vitamin E has not been thoroughly studied, WHO recommends 2 mg/kg/day as the maximum daily dose.

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