이소아스코르브산

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

이소아스코르브산 MSDS

• 2,3-Didehydro-D-erythro-hexono-1,4-lactone

이소아스코르브산 화학적 특성, 용도, 생산

• 순도시험

    (1) 비선광도 : 이 품목 약 1g을 정밀히 달아 새로 끓여 식힌 물에 녹여 10mL로 하고 이 액의 선광도를 측정할 때, ＝-16.5～-18.0°이어야 한다.

    (2) 융점 : 이 품목의 융점은 164～171℃이어야 한다.

    (3) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.

    (4) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.

• 확인시험

    (1) 이 품목 0.1g을 메타인산용액(1→50) 100mL에 녹여 그 중 5mL를 취하고 이에 액이 엷은 황색을 나타낼 때까지 요오드시액을 적가한 다음 황산동용액(1→1,000) 1방울 및 피롤 1방울을 가하여 수욕 중에서 50～60℃로 5분간 가온하면 청～청록색을 나타낸다.

    (2) 이 품목의 수용액(1→100) 10mL에 과망간산칼륨시액 1mL를 가하면 시액의 홍색은 즉시 없어진다.

• 정량법

    이 품목을 건조한 다음 약 0.4g을 정밀히 달아 메타인산용액(1→50)에 녹여 100mL로 하고 그 중 50mL를 취하여 0.1N 요오드용액으로 적정한다(지시약 : 전분시액).

  0.1N 요오드용액 1mL ＝ 8.806mg C₆H₈O₆

• 화학적 성질

  Erythorbic acid occurs as a white or slightly yellow-colored crystals or powder. It gradually darkens in color upon exposure to light.

• 용도

  Erythorbic Acid is a food preservative that is a strong reducing agent (oxygen accepting) which functions similarly to antioxidants. In the dry crystalline state it is nonreactive, but in water solutions it reacts readily with atmospheric oxygen and other oxidizing agents, making it valuable as an antioxidant. During preparation, dissolving and mixing should incorporate a minimum amount of air, and storage should be at cool temperatures. It has a solubility of 43 g/100 ml of water at 25°c. One part is equivalent to one part ascorbic acid and equivalent to one part sodium erythorbate. It is used to control oxidative color and flavor deterioration in fruits at 150–200 ppm. It is used in meat curing to speed and control the nitrite curing reaction and prolong the color of cured meat at levels of 0.05%.

• 생산 방법

  Erythorbic acid is synthesized by the reaction between methyl 2- keto-D-gluconate and sodium methoxide. It can also be synthesized from sucrose, and produced from Penicillium spp.

• Pharmaceutical Applications

  Erythorbic acid is a stereoisomer of L-ascorbic acid, and is used as an antioxidant in foods and oral pharmaceutical formulations. It has approximately 5% of the vitamin C activity of L-ascorbic acid.

• Safety

  Erythorbic acid is widely used in food applications as an antioxidant. It is also used in oral pharmaceutical applications as an antioxidant. Erythorbic acid is generally regarded as nontoxic and nonirritant when used as an excipient. Erythorbic acid is readily metabolized and does not affect the urinary excretion of ascorbic acid.
  The WHO has set an acceptable daily intake of erythorbic acid and its sodium salt in foods at up to 5 mg/kg body-weight.

• Solubility in organics

  40% soluble in water. Soluble in alcohol, slightly soluble in Glycerin and Propylene glycol.

• 저장

  Erythorbic acid should be stored in an airtight container, protected from light, in a cool, dry place.

• Purification Methods

  Crystallise D(-)-isoascorbic acid from H2O, EtOH or dioxane. is at 245nm with 7,500 (EtOH). [Reichstein et al. Helv max Chim Acta 17 510, 516 1934, Heslop et al. J Chem Soc 225 1944, Beilstein 18 III/IV 3037, 18/5 V 26.]

• 비 호환성

  Erythorbic acid is incompatible with chemically active metals such as aluminum, copper, magnesium, and zinc. It is also incompatible with strong bases and strong oxidizing agents.

• Regulatory Status

  GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral concentrate and tablets).

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