모노질산 티아민

모노질산 티아민 화학적 특성, 용도, 생산

• 순도시험

    (1) 액성 : 이 품목의 수용액(1→50)의 pH는 6.5～8.0이어야 한다.

    (2) 염화물 : 이 품목 0.25g을 취하여 염화물시험법에 따라 시험할 때, 그 양은 0.01N 염산 0.4mL에 대응하는 양 이하이어야 한다.

    (3) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.

• 확인시험

    (1)「비타민B₁염산염」의 확인시험 (1), (2)에 따라 시험한다.

    (2) 이 품목은 확인시험법 중 질산염의 반응을 나타낸다.

• 정량법

    「비타민B₁염산염」의 정량법에 따라 정량한다.

• 강열잔류물

    이 품목의 강열잔류물은 0.2% 이하이어야 한다.

• 개요

  Thiamine is a water-soluble vitamin with antioxidant, neuroprotective, and anxiolytic properties. It inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro when used at concentrations ranging from 1 to 100 μM. In vivo, thiamine (100 mg/kg) reduces hepatic levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), lipid peroxidation, and protein damage in a rat model of acute ethanol intoxication. It reverses predator stress-induced suppression of hippocampal neurogenesis and decreases the latency of step-down from a platform, indicating anxiolytic-like activity in mice. Thiamine (8.5 mg/100 g food) reduces neurodegeneration and increases survival in Slc19a3^-/- mice, a model of thiamine metabolism dysfunction syndrome-2 (THMD-2).

• 화학적 성질

  White or almost white, crystalline powder or small, colourless crystals.

• 용도

  Thiamine Nitrate is an orally administered vitamin. Thiamine is a essential nutrient required for carbohydrate metabolism and is involved in nerve function.

• 일반 설명

  Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Thiamine Nitrate is a mononitrate salt of thiamine. It is synthesized from thiamine hydrochloride following a sequence of steps. Thiamine Nitrate is used as a dietary supplement in crackers, eggs substitute and enriched flour.

• Safety Profile

  Poison by intravenous and intraperitoneal routes. A powerful oxidizer. When heated to decomposition it emits very toxic fums of SOx, and NOx. See also NITRATES.

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