쿠레톡심메틸

한글명:쿠레톡심메틸

카스 번호143390-89-0

상품명:Kresoxim-methyl

CBNumberCB6353737

분자식C18H19NO4

포뮬러 무게313.35

MOL 파일143390-89-0.mol

동의어(한글)

쿠레톡심메틸

크레속심-메틸

화학적 성질

녹는점	98-100°C
끓는 점	429.4±47.0 °C(Predicted)
밀도	1.28
증기압	2.3 x 10^-6 P a (20 °C)
저장 조건	Inert atmosphere,2-8°C
용해도	Chloroform: Slightly Soluble,Methanol: Slightly Soluble
물리적 상태	Liquid
수용성	2mg l^-1(20°C)
Specific Gravity	1.28 (20℃)
색상	Colorless to light yellow
BRN	8330581
Henry's Law Constant	2.7×10³ mol/(m³Pa) at 25℃, HSDB (2015)
주요 응용	agriculture cleaning products cosmetics environmental food and beverages personal care
InChI	1S/C18H19NO4/c1-13-8-4-7-11-16(13)23-12-14-9-5-6-10-15(14)17(19-22-3)18(20)21-2/h4-11H,12H2,1-3H3/b19-17+
InChIKey	ZOTBXTZVPHCKPN-HTXNQAPBSA-N
SMILES	CO\N=C(\C(=O)OC)c1ccccc1COc2ccccc2C
LogP	3.44 at 25℃
표면장력	72.8mN/m at 1.8mg/L and 20℃
CAS 데이터베이스	143390-89-0(CAS DataBase Reference)
EPA	Kresoxim-methyl (143390-89-0)

위험 및 안전 성명

위험품 표기	Xn;N,N,Xn
위험 카페고리 넘버	40-50/53
안전지침서	2-36/37-60-61
유엔번호(UN No.)	UN3077 9/PG 3
WGK 독일	3
HS 번호	29252900
스토리지 클래스	11 - Combustible Solids
Hazard Classifications	Aquatic Acute 1 Aquatic Chronic 1 Carc. 2
유해 물질 데이터	143390-89-0(Hazardous Substances Data)
독성	LD50 in rats (mg/kg): >5000 orally; >2000 dermally (Ammerman)

그림문자(GHS)

쿠레톡심메틸 MSDS

쿠레톡심메틸 화학적 특성, 용도, 생산

개요
Kresoxim-methyl is a strobilurin fungicide. It inhibits conidial germination of V. inaequalis isolates from apple orchards (EC₅₀s = 0.00033-0.0078 mg/L). Kresoxim-methyl also inhibits mycelial growth (EC₅₀ = 0.240 mg/L) and is fungicidal against Saprolegnia (MIC = 1 mg/L). It increases intracellular calcium levels and disrupts the mitochondrial membrane potential in mouse cortical cultures in a concentration-dependent manner. Kresoxim-methyl is toxic to goldfish (C. auratus; LC₅₀ = 0.807 mg/L).
용도
Kresoxim-methyl is used for the control of several diseases (scab, mildews, blast, sheath blight and others) on a range of crops including apples, pears, vines, sugar beet and cereals.
정의
ChEBI: A carboxylic ester that is the methyl ester of (2E)-(methoxyimino){2-[(2-methylphenoxy)methyl]phenyl}acetic acid. A fungicide for the control of scab on apples and pears and other fungal diseases on a wide range of crops.
위험도
Moderately toxic by skin contact. Low tox-icity by ingestion and inhalation.
Safety Profile
Moderately toxic by skin contact. Low toxicity by ingestion and inhalation. Questionable carcinogen with experimental data reported. When heated to decomposition it emits toxic vapors of NOx.
신진 대사 경로
By hepatocyte suspensions prepared from goats, pigs, hens, and rats that have been cryopreserved and thawed, BAS 490 F is metabolized via the same pathways as observed using fresh rat hepatocytes. The rate of hydrolysis of 14C-BAS 490 F leading to a carboxylic acid derivative seems to be constant between the cryopreserved and fresh hepatocytes except for goats. The oxidation reaction at the methyl group of the phenoxy ring, leading to the hydroxymethyl analog of the carboxylic acid of BAS 490 F, significantly decreases after cryopreservation, whereas the formation of (E)-2-methoxyimino-2[2-(4- hydroxy-2-methylphenyloxymethyl)phenyl] acetic acid by hydroxylation at the 4-position of the phenoxy ring remains at a constant rate. In pig hepatocytes, the two hydroxylated metabolites of the phenoxy ring, carboxy BAS 409 F and (E)-2-methoxyimino-2-o- hydroxymethylphenyl acetic acid, are formed to a lesser extent after cryopreservation.
신진 대사
Kresoxim-methyl is rapidly metabolized in mammalian systems to the virtually inactive carboxylic acid, accounting for its low toxicity and high level of selectivity. Atharvest residues in cereals and top fruit are <0.05 mg/kg and <1 mg/kg in grapes and vegetables. The soil DT₅₀ = <3 days, and the Koc is 219 to 372. For the main metabolite, the Koc is 17 to 24. Hydrolytic stability tests indicate a DT₅₀ of 34 days at pH 7 but only 7 h at pH 9.

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