2-메틸-4-이소티아졸린-3-온

한글명:2-메틸-4-이소티아졸린-3-온

카스 번호2682-20-4

상품명:2-Methyl-4-isothiazolin-3-one

CBNumberCB0193926

분자식C4H5NOS

포뮬러 무게115.15

MOL 파일2682-20-4.mol

동의어(한글)

메틸이소치아졸리논

2-메틸-4-이소티아졸린-3-온

메칠이소치아졸리논

화학적 성질

녹는점	254-256 °C(lit.)
끓는 점	bp0.03 93°
밀도	1.25 (14% aq.)
증기압	<0.1 mm Hg ( 25 °C)
저장 조건	2-8°C
용해도	클로로포름, 에틸아세테이트에 용해됨
산도 계수 (pKa)	-2.03±0.20(Predicted)
물리적 상태	Solid
색상	노란색
수용성	489g/L at 20℃
BRN	606203
InChIKey	BEGLCMHJXHIJLR-UHFFFAOYSA-N
LogP	-0.486 at 20℃
CAS 데이터베이스	2682-20-4(CAS DataBase Reference)
NIST	3(2H)-isothiazolone, 2-methyl-(2682-20-4)
EPA	2-Methyl-3(2H)-isothiazolone (2682-20-4)

위험 및 안전 성명

위험품 표기	N,C,T
위험 카페고리 넘버	50/53-50-43-34-20/21/22-37-23-22
안전지침서	60-61-36/37/39-26-24-45
유엔번호(UN No.)	UN 3077 9/PG 3
WGK 독일	2
RTECS 번호	FE1250000
위험 등급	8
포장분류	III
HS 번호	29349990
유해 물질 데이터	2682-20-4(Hazardous Substances Data)

그림문자(GHS)

2-메틸-4-이소티아졸린-3-온 화학적 특성, 용도, 생산

개요
2-Methyl-4-isothiazolin-3-one (MI) is an isothiazolinone-derived biocide used for controlling microbial growth in industrial and household products, often in a mixture with 5-chloro-2-methyl-3-isothiazolone (MCI). MI is active against Gram-positive and Gram-negative bacteria, fungi, and yeast with MIC values of 0.0045, 0.0015, >0.01, and 0.0065% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively, when used alone. MIC values are 7 to 200-fold lower when MI is used in combination with MCI. MI decreases neurite outgrowth of rat cortical neurons when used at concentrations of 0.1-3 μM and inhibits Src family kinases in cell-free assays. MI, alone and as a mixture with MCI, can elicit contact sensitization.
화학적 성질
2-Methyl-4-isothiazolin-3-one (MIT) is a colorless,clear liquid with amild odor that is completely soluble in water; mostly soluble in acetonitrile, methanol, and hexane; and slightly soluble in xylene. MIT is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%.
용도
Methylisothiazolinone is a preservative compound widely used in cosmetics. It is a contact allergen and sensitiser. Methylisothiazolinone has recently been identified as a neurotoxin that can damage nerve endings with repeated exposure.
정의
ChEBI: Methylisothiazolinone is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. It is a powerful biocide and preservative and is the minor active ingredient in the commercial product Kathon(TM). It has a role as an antifouling biocide, an antimicrobial agent and an antifungal agent.
제조 방법
2-Methyl-4-isothiazolin-3-one (MIT)is prepared by cyclization of cis-N-methyl-3-thiocyanoacrylamide: NCSCH=CHC(O)NHCH3?SCH=CHC(O)NCH3+HCN
위험도
2-Methyl-4-isothiazolin-3-one(MIT)is allergenic and cytotoxic, and this has led to some concern over its use.A report released by the European Scientific Committee on Cosmetic Products and Non-food Products Intended for Consumers (SCCNFP) in 2003 also concluded that insufficient information was available to allow for an adequate risk assessment analysis of MIT.
색상 색인 번호
MI is generally associated with MCI, in Kathon? CG, MCI/MI, and Euxyl? K 100. This preservative is currently used in water-based products such as cosmetics, paints, and glues. Skin contact with concentrated solution can cause severe irritant dermatitis.
부작용
Early on, dermatitis may occur only on part of the exposed skin. Common patterns include: hand dermatitis，perianal dermatitis, perivulval dermatitis, napkin dermatitis, facial dermatitis, eyelid swelling, and scalp dermatitis. Later, more extensive and severe whole-body contact dermatitis may occur in very sensitive people.

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