레티놀 아세트산

한글명:레티놀 아세트산

카스 번호127-47-9

상품명:Retinyl acetate

CBNumberCB4308339

분자식C22H32O2

포뮬러 무게328.49

MOL 파일127-47-9.mol

동의어(한글)

레티놀아세트산

레티닐아세테이트

화학적 성질

녹는점	57-58 °C
끓는 점	406.22°C (rough estimate)
밀도	1.0474 (rough estimate)
굴절률	1.547-1.555
인화점	14℃
저장 조건	2-8°C
용해도	무수 에탄올: 25mg/mL
물리적 상태	고체 또는 점성 액체
색상	황색 분말
냄새	아민 같은
수용성	녹는
감도	Light & Air Sensitive & Hygroscopic
Merck	14,10013
BRN	1915439
안정성	흡습성, 감광성
InChIKey	QGNJRVVDBSJHIZ-QHLGVNSISA-N
LogP	9.4 at 25℃
CAS 데이터베이스	127-47-9(CAS DataBase Reference)
NIST	Retinol, acetate(127-47-9)
EPA	Retinol acetate (127-47-9)

위험 및 안전 성명

위험품 표기

Xn,Xi,T,F

위험 카페고리 넘버

38-63-36/37/38-53-61-11

안전지침서

36/37-45-37/39-26-53-16

유엔번호(UN No.)

UN1170 - class 3 - PG 2 - Ethanol

WGK 독일

RTECS 번호

VH6825000

F 고인화성물질

1-8-10

TSCA

Yes

HS 번호

29362100

독성

LD50 (10 day) orally in mice: 4100 mg/kg (Kamm)

NFPA 704:

	1
1		1

그림문자(GHS)

레티놀 아세트산 MSDS

레티놀 아세트산 화학적 특성, 용도, 생산

개요
Retinyl acetate (retinol acetate, vitamin A acetate,127-47-9) is a natural form of vitamin A. It is the acetate ester of retinol. It consists of yellow crystals which are greasy or sticky. It has a mild, characteristic odor. It has potential antineoplastic and chemo-preventive activities. It can be used to fortify food with vitamin A. As vitamin A acetate can induce cell differentiation and inhibit cell proliferation, it is used in skin-conditioning agent.
화학적 성질
Retinyl acetate is a yellow, prism-shaped crystal and a lipid-soluble compound, with better chemical stability than vitamin A. In clinical practice, either vitamin A acetate or its palmitate form is typically dissolved in vegetable oil for administration, where it is hydrolyzed by enzymes in the body to release active vitamin A. The form of vitamin A listed in the Chinese Pharmacopoeia refers to the active vitamin A compound.
용도
Retinyl acetate has been used:
- a control diet to study its effect at different developmental periods in fish larvae
- to study its inhibitory effects on Mycobacterium avium?subspecies?paratuberculosis?(MAP) strains
- as an internal standard in high performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk
제조 방법
A method for preparing retinyl acetate the following steps:
Under alkaline conditions, 3-methyl-4-oxo-2-butene-1-yl acetate (referred to as C5 aldehyde ester) and tetraethyl methylene diphosphate undergo a condensation reaction to form an intermediate C6 phosphate (chemical name: 5-(diethyl phosphate)-3-methyl-2,4-hexadiene-1-acetate).
Under alkaline conditions, the C6 phosphate undergoes a transposition reaction. C14 aldehyde (chemical name: 2-methyl-4-(2,6,6-trimethyl-1-cyclohexene-1-yl)-3-butene-1-aldehyde) is then added to undergo a Wittig-Horner condensation reaction, yielding retinyl acetate.
일반 설명
Retinyl acetate is suitable for use in the retention identification of the analyte when using HPLC and GC. Not intended for use as an activity reference standard. It has been thoroughly evaluated to ensure the utmost quality. Neat, unless otherwise noted. Certificate of Composition provided with the purchase.
Safety Profile
Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also VITAMIN A.
Purification Methods
The acetate is separated from retinol by column chromatography, then crystallised from MeOH. [Kofler and Rubin Vitamins and Hormones (NY) 18 315 1960 for purification methods]. Store it in the dark, under N2 or Ar, at 0o. [Beilstein 6 IV 4135.]

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