2-Naphthacencarbonsure-amid, 7-Chlor-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]- Produkt Beschreibung

Chlortetracycline hydrochloride Struktur
64-72-2
  • CAS-Nr.64-72-2
  • Bezeichnung:2-Naphthacencarbonsure-amid, 7-Chlor-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]-
  • Englisch Name:Chlortetracycline hydrochloride
  • Synonyma:2-Naphthacencarbonsure-amid, 7-Chlor-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]-
    CTC;u-6780;nsc-13252;Auxeomycin;Isphamycin;AUREOMYCIN;ortetracycL;Aurofac 100;Aureociclina;Aureocycline
  • CBNumber:CB9737862
  • Summenformel:C22H24Cl2N2O8
  • Molgewicht:515.34
  • MOL-Datei:64-72-2.mol
2-Naphthacencarbonsure-amid, 7-Chlor-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]- physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :210-215 °C (dec.)(lit.)
  • alpha  :D23 -240°
  • storage temp.  :Inert atmosphere,Store in freezer, under -20°C
  • Löslichkeit :1 M NaOH: soluble50mg/mL
  • Aggregatzustand :Powder
  • Farbe :faint yellow to yellow
  • pka :3.3(at 25℃)
  • Wasserlöslichkeit :Soluble in water
  • Sensitive  :Light Sensitive
  • Merck  :13,2211
  • BRN  :3858364
  • CAS Datenbank :64-72-2(CAS DataBase Reference)
  • EPA chemische Informationen :Chlortetracycline hydrochloride (64-72-2)
Sicherheit
  • Kennzeichnung gefährlicher :Xi
  • R-Sätze: :36/37/38
  • S-Sätze: :26-36
  • WGK Germany  :2
  • RTECS-Nr. :QI7800000
  • HazardClass  :3
  • HS Code  :29413020
  • Toxizität :LD50 orally in rats: 10300 mg/kg (Goldenthal)

Chlortetracycline hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  • Chemische Eigenschaften Yellow Solid
  • Verwenden antibacterial, antiamebic, Ca chelator, hepatotoxic; inhibits protein synthesis
  • Verwenden Chlortetracycline is an antibiotic substance isolated from the substrate of Streptomyces aureofaciens. Chlortetracycline is an antimicrobial and antibacterial.
  • Verwenden Chlortetracycline hydrochloride is a salt prepared from chlortetracycline taking advantage of the basic dimethylamino group which protonates and readily forms the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, chlortetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.
  • Verwenden An antimicrobial and antibacterial. This compound contains an undetermined amount of epi-chlortetracycline
  • Trademarks Aureomycin (Lederle).
  • Allgemeine Beschreibung Chlortetracycline (Aureomycin hydrochloride) was isolatedby Duggar in 1948 from S. aureofaciens. This compound,which was produced in an extensive search for new antibiotics,was the first of the group of highly successful tetracyclines.It soon became established as a valuable antibioticwith broad-spectrum activities.
    It is used in medicine chiefly as the acid salt of the compoundwhose systematic chemical designation is 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide.The hydrochloride salt is a crystallinepowder with a bright yellow color, which suggested itsbrand name, Aureomycin. It is stable in air but slightly photosensitiveand should be protected from light. It is odorlessand bitter. One gram of the hydrochloride salt will dissolvein about 75 mL of water, producing a pH of about 3. It isonly slightly soluble in alcohol and practically insoluble inother organic solvents.
    Oral and parenteral forms of chlortetracycline are nolonger used because of the poor bioavailability and inferiorpharmacokinetic properties of the drug. It is still marketed inointment forms for topical and ophthalmic use.
  • läuterung methode Purify the salt by dissolving 1g rapidly in 20mL of hot water, cooling rapidly to 40o, treating with 0.1mL of 2M HCl, and chilling in an ice-bath. The process is repeated twice. It is also recrystallised from Me2NCHO/Me2CO. [Stephens et al. J Am Chem Soc 76 3568 1954, UV: McCormick et al. J Am Chem Soc 79 2849 1975, Beilstein 14 IV 2631.]
Chlortetracycline hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Naphthacencarbonsure-amid, 7-Chlor-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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64-72-2, Chlortetracycline hydrochloride Verwandte Suche:
  • 7-CHLORTETRACYCLINE MONOHYDROCHLORIDE
  • 7-CHLOROTETRACYCLINE HCL
  • 7-CHLOROTETRACYCLINE HYDROCHLORIDE
  • 7-CHLOROTETRACYCLINE MONOHYDROCHLORIDE
  • 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, [4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-
  • CHLOROTETRACYCLINE HYDROCHLORIDEVETRANAL , 250 MG
  • CHLORTETRACYCLINE HYDROCHLORIDE FROM STR EPTOMYCES AUREOFACI
  • Aureociclina, Isphamycin
  • 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S,4aS,5aS,6S,12aS)-
  • 2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride
  • 6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-ydro-monohydrochloride
  • Aureociclina
  • Aureocycline
  • Auxeomycin
  • chlortetracyclinehydrochloride’canbeusedassecondarystandard’
  • clorotetraciclinacloridrato
  • Isphamycin
  • nsc-13252
  • u-6780
  • CHLOROTETRACYCLINE HCL
  • CHLOROTETRACYCLINE HYDROCHLORIDE
  • CHLORTETRACYCLINE HCL
  • CHLORTETRACYCLINE HYDROCHLORIDE
  • CTC
  • AUREOMYCIN
  • AUREOMYCIN HCL
  • AUREOMYCIN HYDROCHLORIDE
  • AUREOMYCIN(TM)
  • [4s-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
  • 2-NaphthacenecarboxaMide, 7-chloro-4-(diMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-Methyl-1,11-dioxo-,hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)-
  • Chlorotetracy
  • Chlorterracycline Hydrochloride
  • Chlortetracycline hydrochloride Solution, 100ppm
  • Chlortetracycline for system suitability
  • Aureomycin/Chlortetracycline hcl
  • Chlortetracycline Hydrochloride(CTC HCL)
  • 7-Chlorotetracycline hydrochloride CTC
  • Chlrtetracycline hydrochloride
  • Chlorotetracycline hydrochloride, USP
  • Lymecycline Impurity 7(Lymecycline EP Impurity G)
  • ortetracycL
  • CHLORTETRACYCLINEHYDROCHLORIDE,CRYSTAL
  • Auxeomycin hydrochloride.
  • Chlortetracycline Hc1
  • 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro- 3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride
  • 4-Chlorotetracycline hydrochloride
  • Fermycin Soluble
  • Biomycin hydrochloride
  • CHLORTETRACYCLINE.HYDROCHLORIDERESEARCH GRADE
  • Chlortetracycline hydrochloride, conforms to Eur. Ph.
  • Chlortetracycline hydrochloride,7-Chlorotetracycline hydrochloride
  • Chlortetracycline Hydrochloride (200 mg)
  • Chlortetracycline Hydrochloride (200 mg)K0C1851008ug/mg(ai)
  • (4S,4aS,5aS,6S,12aS)-7-Chloro-4-(diMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-Methyl-1,11-dioxo-2-naphthacenecarboxaMide Hydrochloride
  • AureoMycin Monohydrochloride
  • Aureovit 12C80
  • Aurofac 100
  • ChlortetracycliniuM Chloride