2-Chlorbenzoylchlorid

Bezeichnung:2-Chlorbenzoylchlorid

CAS-Nr609-65-4

Englisch Name:2-Chlorobenzoyl chloride

CBNumberCB9721544

SummenformelC7H4Cl2O

Molgewicht175.01

MOL-Datei609-65-4.mol

Synonyma

2-Chlorbenzoylchlorid

2-Chlorbenzoylchlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	-4--3 °C (lit.)
Siedepunkt	238 °C (lit.)
Dichte	1.382 g/mL at 25 °C (lit.)
Dampfdruck	0.1 hPa (20 °C)
Brechungsindex	n20/D 1.572(lit.)
Flammpunkt	>230 °F
storage temp.	Store below +30°C.
Aggregatzustand	Liquid
Farbe	Clear colorless to very slightly yellow
Explosionsgrenze	1.5-9.4%(V)
Wasserlöslichkeit	Soluble in acetone, ether, and alcohol. Solubility in water it decomposes.
Sensitive	Moisture Sensitive
BRN	386435
CAS Datenbank	609-65-4(CAS DataBase Reference)
NIST chemische Informationen	Benzoyl chloride, 2-chloro-(609-65-4)
EPA chemische Informationen	Benzoyl chloride, 2-chloro- (609-65-4)

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	34
S-Sätze:	26-36/37/39-45-28A
RIDADR	UN 3265 8/PG 2
WGK Germany	1
F	19-21
Selbstentzündungstemperatur	600 °C
Hazard Note	Corrosive/Moisture Sensitive
TSCA	Yes
HazardClass	8
PackingGroup	II
HS Code	29163900
Toxizität	LD50 orally in Rabbit: 3250 mg/kg

Gefahreninformationscode (GHS)

2-Chlorobenzoyl chloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
clear colourless to very slightly yellow liquid
Verwenden
2-Chlorobenzoyl chloride, is used in organic synthesis. It is used as a pharmaceutical intermediate for eg as an intermediate of clotrimazolc, preparation of p-chlorobenzoic acid and production of trichloro-acaricide.
Definition
ChEBI: An acyl chloride consisting of benzoyl chloride having a chloro substituent in the ortho-position.
Allgemeine Beschreibung
2-Chlorobenzoyl chloride reacts with aromatic amines and ammonium thiocyanate using polyethylene glycol-400 as the catalyst under the condition of solid-liquid phase-transfer catalysis to form N-aryl-N′(2-chlorobenzoyl) thioureas. 2-Chlorobenzoyl chloride causes the acylation of polystyrene during the preparation and regeneration of the polystyrene-based resin.
Synthese
A process for preparing 2-chlorobenzoyl chloride which comprises reacting 2-chlorobenzaldehyde with chlorine in the presence of phosphorus pentachloride at a temperature of from 50° to 200° C. and wherein the 2-chlorobenzaldehyde: phosphorus pentachloride ratio is from 1:0.05 to 1:0.2. Phosphorus pentachloride (41.5 g, 0.2 mole) was added to 2-chlorobenzaldehyde (289.7 g, 2.0 mole, 97%). After the ensuing exotherm had subsided, the resulting red solution was heated to 160° C. A stream of chlorine was introduced through a sparge tube into the solution for six hours. (Gas chromatography indicated 96.5% conversion.) The solution was then cooled and distilled under reduced pressure, giving 325.4 grams of 2-chlorobenzoyl chloride, which boiled at 135° to 140° C. at 16 millimeters of mercury. The yield of 2-Chlorobenzoyl chloride was 93% (98.5% pure).

2-Chlorobenzoyl chloride Upstream-Materialien And Downstream Produkte

2-Chlorbenzoylchlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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