Cholinchlorid

Bezeichnung:Cholinchlorid

CAS-Nr67-48-1

Englisch Name:Choline chloride

CBNumberCB6166667

SummenformelC5H14ClNO

Molgewicht139.62

MOL-Datei67-48-1.mol

Synonyma

Cholinchlorid

(2-Hydroxyethyl)trimethylammoniumchlorid

Cholinhydrochlorid

Cholinchlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	302-305 °C (dec.) (lit.)
Dichte	1.0238 (rough estimate)
Brechungsindex	1.5400 (estimate)
FEMA	4500 \| Choline chloride (Also Includes Choline)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	H₂O: 1 M, clear, colorless
Aggregatzustand	Adhering Crystals
Farbe	White
Geruch (Odor)	sl. odor of trimethylamine
PH	5.0-7.5 (25℃, 1M in H2O)
Wasserlöslichkeit	soluble
Sensitive	Hygroscopic
maximale Wellenlänge (λmax)	λ: 260 nm Amax: 0.015 λ: 280 nm Amax: 0.010
JECFA Number	2003
Merck	14,2206
BRN	3563126
Stabilität	Stable. Incompatible with strong oxidizing agents, moisture. Store under a dry atmosphere.
InChIKey	SGMZJAMFUVOLNK-UHFFFAOYSA-M
LogP	-3.70
CAS Datenbank	67-48-1(CAS DataBase Reference)
NIST chemische Informationen	Choline chloride(67-48-1)
EPA chemische Informationen	Choline chloride (67-48-1)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	1
RTECS-Nr.	KH2975000
F	3-9
TSCA	Yes
HS Code	29212900
Giftige Stoffe Daten	67-48-1(Hazardous Substances Data)
Toxizität	LD50 in rats (g/kg): 0.400 i.p.; 6.64 orally (Hartung, Cornish)

Gefahreninformationscode (GHS)

Choline chloride Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
WEISSE HYGROSKOPISCHE KRISTALLE
CHEMISCHE GEFAHREN
Beim Verbrennen Bildung giftiger und ätzender Rauche mit Chlorwasserstoff. Reagiert mit starken Oxidationsmitteln.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
INHALATIONSGEFAHREN
Eine belästigende Partikelkonzentration in der Luft kann beim Dispergieren schnell erreicht werden.
LECKAGE
Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern.
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White crystalline powder
Verwenden
choleretic, lipotropic, hepatoprotectant
Verwenden
Choline chloride helps in providing nourishment for pig feed and poultry feed. It acts as a food flavor enhancer. It is used as a precursor of acetylcholine and is a methyl donor in various metabolic processes and in lipid metabolism.
Application
Choline chloride has been used:
as a component of choline acetyltransferase (ChAT) buffer and for choline uptake in cultured human neuroblastoma (SK-N-SH) cells
for choline standard curve generation for quantifying phospholipase D (PLD) activity
as a component of slice solution for the dissection of entorhinal-hippocampal brain slices
Definition
ChEBI: Choline chloride is a quaternary ammonium salt with choline cation and chloride anion. It has a role as an animal growth promotant. It is a chloride salt and a quaternary ammonium salt. It contains a choline.
Allgemeine Beschreibung
Choline chloride appears as white crystals. Practically neutral aqueous solution(NTP, 1992). It is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
Air & Water Reaktionen
Deliquescent. Very soluble in water.
Reaktivität anzeigen
An acidic organic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
Brandgefahr
Choline chloride is relatively nonflammable.
Biochem/physiol Actions
The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .
Sicherheitsprofil
Poison by intraperitoneal and intravenous routes. Moderately toxic experimentally by ingestion and subcutaneous routes. Mutation data reported. A lipotropic agent which induces the reduction in fats contained in the liver. When heated to decomposition it emits toxic fumes of Cl-, SOx and NOx. See also CHOLINE.
läuterung methode
Extremely deliquescent. Check purity by AgNO3 titration or by titration of OH-base after passage through an anion-exchange column. Crystallise it from absolute EtOH, or EtOH/Et2O, dry it under vacuum and store it in a vacuum desiccator over P2O5 or Mg(ClO4)2. [Beilstein 4 IV 1443.]

Choline chloride Upstream-Materialien And Downstream Produkte

Cholinchlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

67-48-1, Choline chloride Verwandte Suche:

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