4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid

Bezeichnung:4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid

CAS-Nr959-24-0

Englisch Name:Sotalol hydrochloride

CBNumberCB9712098

SummenformelC12H21ClN2O3S

Molgewicht308.82

MOL-Datei959-24-0.mol

Synonyma

4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid

4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	218-220°C
storage temp.	2-8°C
Löslichkeit	H₂O: 20 mg/mL
Aggregatzustand	powder
Farbe	white to off-white
Wasserlöslichkeit	Soluble in phosphate buffered saline, DMSO, ethanol, water, and methanol.
CAS Datenbank	959-24-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	PB0826000
HS Code	2935904000
Toxizität	LD50 in male mice, rats (mg/kg): 2600, 3450 orally; 670, 680 i.p.; LD50 orally in rabbits: 1000 mg/kg; LD50 i.p. in dogs: 330 mg/kg (Lish)

Gefahreninformationscode (GHS)

Sotalol hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Sotalol (hydrochloride) (Item No. 26291) is an analytical reference standard categorized as a β-adrenergic receptor antagonist. It has been detected as an adverse analytical finding (AAF) during anti-doping testing. This product is intended for use in analytical forensic applications. This product is also available as a general research tool .
Beschreibung
Sotalol is a non-selective antagonist of β-adrenergic receptors (β-ARs; IC₅₀s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 μM. Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES). Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).
Chemische Eigenschaften
White Crystalline Solid
Originator
Sotagard,Glaxo
Verwenden
antibacterial
Verwenden
Sotalol hydrochloride is used as a potent beta adrenergic antagonist, prolongs the action potential and increases the refractory period. Sotalol hydrochloride is also considered a non-selective β blocker and a potassium channel blocker with an IC50 of 43 μM.
Verwenden
A potent α-adrenergic receptor antagonist. A class III antiarrythmic. It has been shown to prolong action potential and increases the refractory period.
Verwenden
A potent -adrenergic receptor antagonist. A class III antiarrythmic. It has been shown to prolong action potential and increases the refractory period
Definition
ChEBI: A hydrochloride salt that is the monohydrochloride of sotalol. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Manufacturing Process
As a resulting of reaction of methansulfonylchloride reacted with aniline methansulfonanilide was obtained. The methansulfonanilide reacted with bromacetylbromide at the presence of AlCl3 and CS2 and 4-(bromacetyl)- methansulfonanilide was prepeared.
Then to the 4-(bromacetyl)-methansulfonanilide isopropylamine was added to give 4-(1-oxo-2-isopropylaminoethyl)methansulfonanilide.The 4-(1-oxo-2-isopropylaminoethyl)methansulfonanilide was reduced by hydrogenesation in the presence of Pd-C catalyst and sodium borohydride. So 4-(1-hydroxy-2-isopropylaminoethyl)methansulfonanilide was obtained.
The 4-(1-hydroxy-2-isopropylaminoethyl)methansulfonanilide hydrochloride may be prepared by treatment of base with hydrochloric acid.
Trademarks
Betapace(Berlex); Sorine (Upsher Smith).
Therapeutic Function
Beta-adrenergic blocker, Antiarrhythmic
Biologische Aktivität
A relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity. Also available as part of the Mixed Adrenergic Tocriset™ .
Clinical Use
Beta-adrenoceptor blocker:
Treatment of life-threatening ventricular arrhythmias
Prophylaxis of SVT
Veterinary Drugs and Treatments
Sotalol may be useful in the treatment of ventricular tachycardias and, possibly, supraventricular tachycardias in dogs.
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: NSAIDs antagonise hypotensive effect.
Anti-arrhythmics: increased risk of myocardial depression and bradycardia; increased risk ofbradycardia, myocardial depression and AV block with amiodarone; increased risk of ventricular arrhythmias with amiodarone, dronedarone, disopyramide or procainamide - avoid; increased risk of myocardial depression and bradycardia with flecainide.
Antibacterials: increased risk of ventricular arrhythmias with moxifloxacin - avoid; increased risk of ventricular arrhythmias with delamanid.
Antidepressants: enhanced hypotensive effect with MAOIs; increased risk of ventricular arrhythmias with tricyclics; increased risk of ventricular arrhythmias with citalopram, escitalopram and venlafaxine - avoid.
Antihistamines: increased risk of ventricular arrhythmias with mizolastine - avoid.
Antihypertensives: enhanced hypotensive effect; increased risk of withdrawal hypertension with clonidine; increased risk of first dose hypotensive effect with post-synaptic alpha-blockers such as prazosin.
Antimalarials: increased risk of bradycardia with mefloquine; avoid with artemether and lumefantrine and piperaquine with artenimol - increased risk of ventricular arrhythmias.
Antimuscarinics: increased risk of ventricular arrhythmias with tolterodine.
Antipsychotics: enhanced hypotensive effect with phenothiazines; increased risk of ventricular arrhythmias with amisulpride, droperidol, haloperidol, phenothiazines, pimozide, risperidone, sulpiride or zuclopenthixol - avoid with droperidol and zuclopenthixol.
Antivirals: increased risk of ventricular arrhythmias with saquinavir or telaprevir - avoid.
Atomoxetine: increased risk of ventricular arrhythmias.
Calcium-channel blockers: increased risk of bradycardia and AV block with diltiazem; hypotension and heart failure possible with nifedipine and nisoldipine; asystole, severe hypotension and heart failure with verapamil.
Cytotoxics: possible increased risk of bradycardia with crizotinib; increased risk of ventricular arrhythmias with vandetanib - avoid; increased risk of ventricular arrhythmias with arsenic trioxide, bosutinib, ceritinib, panobinostat and vandetanib.
Diuretics: enhanced hypotensive effect; increased risk of ventricular arrhythmias due to hypokalaemia.
Fingolimod: possibly increased risk of bradycardia.
Ivabradine: increased risk of ventricular arrhythmias.
Moxisylyte: possible severe postural hypotension. Ranolazine: avoid concomitant use.
Sympathomimetics: severe hypertension with adrenaline and noradrenaline and possibly with dobutamine.
Stoffwechsel
Metabolism of sotalol is negligible, and it is excreted unchanged in the urine.
Lager
Store at RT

Sotalol hydrochloride Upstream-Materialien And Downstream Produkte

4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

959-24-0, Sotalol hydrochloride Verwandte Suche:

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