Chlortoluol (o)

Bezeichnung:Chlortoluol (o)

CAS-Nr95-49-8

Englisch Name:2-Chlorotoluene

CBNumberCB9245073

SummenformelC7H7Cl

Molgewicht126.58

MOL-Datei95-49-8.mol

Synonyma

2-Chlortoluol

Chlortoluol (o)

1-Chlor-2-methylbenzol

Chlortoluol (o) physikalisch-chemischer Eigenschaften

Schmelzpunkt	-36 °C (lit.)
Siedepunkt	157-159 °C (lit.)
Dichte	1.083 g/mL at 25 °C (lit.)
Dampfdichte	4.38 (vs air)
Dampfdruck	10 mm Hg ( 43 °C)
Brechungsindex	n20/D 1.525(lit.)
Flammpunkt	117 °F
storage temp.	0-6°C
Löslichkeit	H2O: slightly soluble0.047g/L at 20°C
Aggregatzustand	Liquid
Farbe	Clear
Explosionsgrenze	1.0-12.6%(V)
Wasserlöslichkeit	slightly soluble
Merck	14,2171
BRN	1904175
Dielectric constant	4.4500000000000002
Expositionsgrenzwerte	ACGIH: TWA 50 ppm NIOSH: TWA 50 ppm(250 mg/m3); STEL 75 ppm(375 mg/m3)
InChIKey	IBSQPLPBRSHTTG-UHFFFAOYSA-N
LogP	3.42 at 25℃
CAS Datenbank	95-49-8(CAS DataBase Reference)
NIST chemische Informationen	Benzene, 1-chloro-2-methyl-(95-49-8)
EPA chemische Informationen	o-Chlorotoluene (95-49-8)

Sicherheit

Kennzeichnung gefährlicher	Xn,N,F,Xi,T
R-Sätze:	20-51/53-39/23/24/25-23/24/25-11
S-Sätze:	24/25-61-45-36/37-16-7
RIDADR	UN 2238 3/PG 3
OEB	A
OEL	TWA: 50 ppm (250 mg/m3), STEL: 75 ppm (375 mg/m3)
WGK Germany	2
RTECS-Nr.	XS9000000
Selbstentzündungstemperatur	600°C
Hazard Note	Irritant/Flammable
TSCA	Yes
HazardClass	3
PackingGroup	III
HS Code	29036990
Giftige Stoffe Daten	95-49-8(Hazardous Substances Data)

Gefahreninformationscode (GHS)

2-Chlorotoluene Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
FARBLOSE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.
CHEMISCHE GEFAHREN
Beim Verbrennen Bildung giftiger und ätzender Rauche mit Chlorwasserstoffund Phosgen. Reagiert mit Oxidationsmitteln.
ARBEITSPLATZGRENZWERTE
TLV: 50 ppm (als TWA); (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C tritt langsam eine gesundheitsschädliche Kontamination der Luft ein; viel schneller jedoch beim Versprühen oder Dispergieren.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Augen, die Haut und die Atemwege.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Die Flüssigkeit entfettet die Haut.
LECKAGE
Belüftung. Zündquellen entfernen. Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzfilter für organsiche Gase und Dämpfe. NICHT in die Umwelt gelangen lassen.
R-Sätze Betriebsanweisung:
R20:Gesundheitsschädlich beim Einatmen.
R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R11:Leichtentzündlich.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S7:Behälter dicht geschlossen halten.
Beschreibung
2-Chlorotoluene can be mineralized completely by Rhodococcus, strain OCT 10 DSM 45596(T). It is used in the preparation of 3-chloro-4-methylcatechol and 4-chloro-3-methylcatechol. The oxidation of 2-chlorotoluene is very well catalyzed by the enzymes: toluene dioxygenase of P. putida F1 and chlorobenzene dioxygenase from Burkholderia, strain PS12.
Chemische Eigenschaften
o-Chlorotoluene is a flammable, colorless liquid with an aromatic odor.
Verwenden
Solvent and intermediate for organic chemicals and dyes.
2-Chlorotoluene is used for permanganate oxidation to give o-chlorobenzoic acid. It is used in the preparation of 3-chloro-4-methylcatechol and 4-chloro-3-methylcatechol.
2-Chlorotoluene can be used as a precursor to synthesize aryl coupling products via palladium-catalyzed Negishi cross-coupling. It can also be used in the Buchwald-Hartwig amination to synthesize arylamines.
Verwenden
Solvent; synthesis of dyes, pharmaceuticals, and synthetic rubber compounds
synthetische
The solution of cuprous chloride is cooled in an ice bath 0-5° C temperature. In this cold solution, the 2-methylbenzenediazonium is poured with constant shaking and allowing the mixture to come to room temperature. After about 10 minutes, the mixture gradually warmed with a good shaking.As the temperature rises the brown addition product begins to decompose with the evolution of nitrogen and with the formation of an oily layer of 2-chlorotoluene. When the decomposition reaction is at an end, the mixture is steam distilled, continuing the process only as long as oily droplets are present in the distillate, for the product is not appreciably soluble in water. The layer of 2-chlorotoluene is carefully separated and washed twice with an equal volume of concentrated sulfuric acid, which removes both the 2-cresol and the azo compound. Then 2-chlorotoluene is washed with water in order to remove the inorganic acid. Finally, 2-chlorotoluene is dried over calcium chloride, distilled, using an air condenser and collecting the product boiling at 153-158° C. Pure 2-chlorotoluene boils at 157° C. The yield is 25-30 g.

Experiments in Organic Chemistry, L. F. Fieser, 216, 1941
Highly Selective Oxidative Monochlorination To Synthesize Organic Intermediates: 2-Chlorotoluene, 2-Chloroaniline, 2-Chlorophenol, and 2-Chloro-4-methylphenol
Synthesis Reference(s)
Journal of the American Chemical Society, 101, p. 768, 1979 DOI: 10.1021/ja00497a063
Organic Syntheses, Coll. Vol. 1, p. 170, 1941
Allgemeine Beschreibung
Colorless liquid with an aromatic odor. Denser than water and poorly soluble in water. Hence sinks in water .
Air & Water Reaktionen
Slightly water soluble.
Reaktivität anzeigen
2-Chlorotoluene may be incompatible with strong oxidizing and reducing agents. Also may be incompatible with amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. Reacts violently with dimethyl sulfoxide .
Hazard
Toxic by inhalation. Eye, skin, and upper respiratory tract irritant.
Health Hazard
Inhalation of vapor may cause respiratory irrtation. Prolonged and repeated vapor exposures may produce systemic toxic effects.
Flammability and Explosibility
Flammable
Sicherheitsprofil
Moderately toxic by unspecified routes. Flammable when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Cl-. See also TOLE CHLORIDE and CHLORINATED HYDROCARBONS, AROMATIC.
mögliche Exposition
o-Chlorotoluene is widely used as a solvent and intermediate in the synthesis of dyes, synthetic rubber; pharmaceuticals; and other organic chemicals. Used as an insecticide, bactericide.
Erste Hilfe
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit
Lager
Color Code—Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.Prior to working with o-chlorotoluene you should be trainedon its proper handling and storage. Store in tightly closedcontainers in a cool, well-ventilated area. Metal containersinvolving the transfer of this chemical should be groundedand bonded. Drums must be equipped with self-closingvalves, pressure vacuum bungs, and flame arresters. Useonly nonsparking tools and equipment, especially whenopening and closing containers of this chemical. Sources ofignition, such as smoking and open flames, are prohibitedwhere this chemical is used, handled, or stored in a mannerthat could create a potential fire or explosion hazard.
Versand/Shipping
UN2238 Chlorotoluenes, Hazard Class: 3; Labels: 3-Flammable liquid.
läuterung methode
Dry 2-chlorotoluene for several days with CaCl2, then distil it from Na using a glass helices-packed column. [Beilstein 5 IV 805.]
Inkompatibilitäten
Incompatible with acids, alkalis, oxidizers, reducing materials; water
Waste disposal
In accordance with 40CFR165 recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

2-Chlorotoluene Upstream-Materialien And Downstream Produkte

Chlortoluol (o) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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