Chlorbenzol

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H226：Flüssigkeit und Dampf entzündbar.

  H315：Verursacht Hautreizungen.

  H332：Gesundheitsschädlich bei Einatmen.

  H411：Giftig für Wasserorganismen, mit langfristiger Wirkung.

• Sicherheit

  P210：Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.

  P233：Behälter dicht verschlossen halten.

  P240：Behälter und zu befüllende Anlage erden.

  P273：Freisetzung in die Umwelt vermeiden.

  P303+P361+P353：BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.

Chlorobenzene Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.

• CHEMISCHE GEFAHREN

  Zersetzung beim Erhitzen bei Kontakt mit heißen Oberflächen oder Flammen unter Bildung giftiger und ätzender Rauche. Reagiert sehr heftig mit starken Oxidationsmitteln unter Feuer- und Explosionsgefahr. Greift Gummi und einige Kunststoffe an.

• ARBEITSPLATZGRENZWERTE

  TLV: 10 ppm (als TWA); Krebskategorie A3 (bestätigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); BEI vorhanden; (ACGIH 2005).
  MAK: 10 ppm, 47 mg/m? Spitzenbegrenzung: überschreitungsfaktor II(2); Schwangerschaft: Gruppe C; (DFG 2005).
  EG Arbeitsplatz-Richtgrenzwerte: 23 mg/m? 5 ppm (als TWA); 70 mg/m? 15 ppm (als STEL); (EG 2006)
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation der Dämpfe, über die Haut und durch Verschlucken.

• INHALATIONSGEFAHREN

  Beim Verdampfen bei 20°C kann schnell eine gesundheitsschädliche Kontamination der Luft eintreten.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Substanz reizt die Augen und die Haut. Verschlucken kann zur Aufnahme in der Lunge führen; Gefahr der Aspirationspneumonie. Möglich sind Auswirkungen auf das Zentralnervensystem mit nachfolgender Bewusstseinstrübung.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Die Flüssigkeit entfettet die Haut. Möglich sind Auswirkungen auf Leberund Nieren.

• LECKAGE

  Belüftung. Zündquellen entfernen. Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. NICHT in die Umwelt gelangen lassen. Persönliche Schutzausrüstung: Atemschutzfilter für organische Gase und Dämpfe.

• R-Sätze Betriebsanweisung:

  R10:Entzündlich.
  R20:Gesundheitsschädlich beim Einatmen.
  R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
  R40:Verdacht auf krebserzeugende Wirkung.
  R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
  R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
  R11:Leichtentzündlich.

• S-Sätze Betriebsanweisung:

  S24/25:Berührung mit den Augen und der Haut vermeiden.
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

• Aussehen Eigenschaften

  Monochlorbenzol, C6H5Cl; farblose, wasserunlösliche, angenehm riechende Flüssigkeit.

• Gefahren für Mensch und Umwelt

  Entzündlich; Dämpfe und Nebel können mit Luft explosionsfähige Gemische bilden (Vorsicht! Dämpfe sind schwerer als Luft und sammeln sich deshalb am Boden, in Kanalisation, usw.). Kunststoffe werden angegriffen. Gefährliches Zersetzungsproduktsind HCl und Phosgen.
  Eingeatmete Lösemitteldämpfe wirken in hohen Konzentrationen betäubend; Nervenschäden sind möglich. Reizung von Haut und Schleimhäuten; bei häufigem Hautkontakt Entfettung und Entzündungen. Kann über die Haut aufgenommen werden! Fruchtschädigung möglich!
  Wassergefährdungsklasse 2.

• Schutzmaßnahmen und Verhaltensregeln

  Im Abzug arbeiten! Von Zündquellen fernhalten.
  Latex- oder Neoprenschutzhandschuhe nur als kurzzeitigen Spritzschutz verwenden.

• Verhalten im Gefahrfall

  Nach Verschütten mit inertem Saugmaterial (Sand, Kieselgur) aufnehmen und als Sondermüll entsorgen.
  Wassernebel, Kohlendioxid, Trockenlöschmittel, Schaum.

• Erste Hilfe

  Nach Hautkontakt: Sofort mit viel Wasser und Seife gründlich abwaschen.
  Nach Augenkontakt: Augen mindestens 15 Minuten bei geöffnetem Lidspalt gründlich ausspülen und Arzt konsultieren.
  Nach Einatmen: Frischluft; bei anhaltendem Unwohlsein zum Arzt.
  Nach Verschlucken: Wasser trinken, Erbrechen vermeiden, sofort zum Arzt.
  Nach Kleidungskontakt: Benetzte Kleidung sofort wechseln.
  Ersthelfer: siehe gesonderten Anschlag

• Sachgerechte Entsorgung

  Halogenhaltige Lösungsmittel.

• Beschreibung

  Chlorobenzene is a colorless liquid with analmond-like odor. The odor threshold is between 0.1 and3.0 μg/L. Also reported in the literature at 0.68 and0.741 ppm. Molecular weight=112.56; Boilingpoint=131-132℃; Freezing/Melting point=2 45℃;Flash point=28℃; Autoignition temperature=593℃.Flammable limits are: LEL=1.3%; UEL=9.6%. HazardIdentification (based on NFPA 704 M Rating System):Health 2, Flammability 3, Reactivity 1. Insoluble in water.

• Chemische Eigenschaften

  Chlorobenzene, also known as monochlorobenzene or MCB, is a colourless flammable liquid with an aromatic almond-like odor, Chlorination of benzene in the presence of a catalyst (FeCl3 or AICI3) yields chlorobenzene as the first product. It is insoluble in water and miscible with organic solvents. Chlorobenzene has a good solvency for fats, oils, resins, polymers, binders, rubber, and chlorinated rubber. Cellulose ethers dissolve in the presence of small amounts of alcohols; cellulose nitrate is insoluble. Chlorobenzene is a solvent in the production of bitumen and asphalt coatings for building protection.

• Physikalische Eigenschaften

  Clear, colorless, flammable liquid with a sweet almond, medicinal or mothball-like odor. An odor threshold concentration of 210 ppbv was reported by Leonardos et al. (1969). At 40 °C, the lowest concentration at which an odor was detected was 190 μg/L. At 25 °C, the lowest concentration at which a taste was detected was 190 μg/L (Young et al., 1996). The average least detectable odor threshold concentration in water at 60 °C was 0.08 mg/L (Alexander et al., 1982). Cometto-Muiz and Cain (1994) reported an average nasal pungency threshold concentration of 10,553 ppmv. Chlorobenzene can evaporate when exposed to air. It dissolves slightly when mixed with water. It is moderately soluble in water; up to 1,000 milligrams will mix with a liter of water. Chlorobenzene is slightly persistent in water, with a half-life of between 2 to 20 days. It persists in soil (several months), in air (3.5 days), and water (less than 1 day).

• Verwenden

  Chlorobenzene is a halogenated benzene that is used as a solvent for paints, as a heat transfer medium, and in the manufacture of phenol, aniline and nitrochlorobenzenes. Now chlorobenzene is mainly used as a solvent for pesticide formulations, diisocyanate manufacture, degreasing automobile parts, and for the production of nitrochlorobenzene and chemical toxicity QSAR research for agricultural pollution.

• Definition

  ChEBI: Chlorobenzene is the simplest member of the class of monochlorobenzenes, that is benzene in which a single hydrogen has been substituted by a chlorine. It has a role as a solvent.

• synthetische

  Chlorobenzene is produced by chlorination of benzene in the presence of a catalyst, and is produced as an end product in the reductive chlorination of di- and trichlorobenzenes.

• Synthesis Reference(s)

  Journal of the American Chemical Society, 74, p. 6297, 1952 DOI: 10.1021/ja01144a523
  Tetrahedron Letters, 23, p. 371, 1982 DOI: 10.1016/S0040-4039(00)86833-1

• Allgemeine Beschreibung

  Chlorobenzene is a colorless to clear, yellowish liquid with a sweet almond-like odor. Flash point 84°F. Practically insoluble in water and somewhat denser than water (9.2 lb / gal). Vapors heavier than air. It can be converted to phenol by reaction with sodium hydroxide under extreme conditions (300°C and 200 atmospheres pressure). Used to make pesticides, dyes, and other chemicals.

• Air & Water Reaktionen

  Highly flammable. Insoluble in water.

• Reaktivität anzeigen

  Chlorobenzene undergoes a sometimes explosive reaction with powdered sodium or phosphorus trichloride + sodium. May react violently with dimethyl sulfoxide. Reacts vigorously with oxidizing agents. Attacks some forms of plastic, rubber and coatings. Forms a shock sensitive solvated salt with silver perchlorate.

• Hazard

  A possible carcinogen. Avoid inhalation and skin contact. Moderate fire risk. Explosive limits 1.8–9.6%.

• Health Hazard

  Irritating to skin, eyes and mucous membranes. Repeated exposure of skin may cause dermatitis due to defatting action. Chronic inhalation of vapors or mist may result in damage to lungs, liver, and kidneys. Acute vapor exposures can cause symptoms ranging from coughing to transient anesthesia and central nervous system depression.
  Limited information is available on the acute (short-term) effects of chlorobenzene. Acute inhalation exposure of animals to chlorobenzene produced narcosis, restlessness, tremors, and muscle spasms. Chronic (long-term) exposure of humans to chlorobenzene affects the central nervous system (CNS). Signs of neurotoxicity in humans include numbness, cyanosis, hyperesthesia (increased sensation), and muscle spasms. No information is available on the carcinogenic effects of chlorobenzene in humans. EPA has classified chlorobenzene as a Group D, not classifiable as to human carcinogenicity.

• Brandgefahr

  Flammable liquid; flash point (closed cup) 29°C (84°F); vapor pressure 8.8 torr at 20°C (68°F); autoignition temperature 638°C (1180°F). When heated to decomposition this compound emits toxic fumes of hydrogen chloride gas, CO and CO2.
  Chlorobenzene vapors form explosive mixtures with air within the range 1.3-7.1% by volume in air. It is incompatible with strong oxidizing agents and dimethyl sulfoxide. Dimethyl sulfoxide decom poses violently in contact with chloroben zene (NFPA 1997). Many metal perchlorates, such as those of silver and mercury, may form shock-sensitive solvated perchlorates that may explode on impact.

• Flammability and Explosibility

  Flammable

• Sicherheitsprofil

  Suspected carcinogen. Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. Mutation data reported. Strong narcotic with slight irritant qualities. Dichlorobenzols are strongly narcotic. Little is known of the effects of repeated exposures at lower concentrations, but it may cause hdney and liver damage. The industrial illnesses reported may possibly be due to nitrobenzol. Dangerous fire hazard when exposed to heat or flame. Moderate explosion hazard when exposed to heat or flame. Potentially explosive reaction with powdered sodium or phosphorus trichloride + sodtum. Violent reaction with AgClO4. Reacts vigorously with oxidizers. See also CHLORINATED HYDROCARBONS, AROMATIC. To fight fire, use foam, CO2, dry chemical, water to blanket fire. Associated with EPA Superfund sites

• mögliche Exposition

  Chlorobenzene is used in the manufacture of aniline, phenol, and chloronitrobenzene; as an intermediate in the manufacture of dyestuffs and many pesticides, as a solvent; and emulsifier.

• Erste Hilfe

  If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.Medical observation is recommended.
  Note to physician: Treat for methemoglobinemia.Spectrophotometry may be required for precise determination of levels of methemoglobinemia in urine.

• Carcinogenicity

  Chlorobenzene was not mutagenic in a variety of bacterial and yeast assays. Existing data suggest that genotoxicity may not be an area of concern for chlorobenzene exposure in humans.

• Environmental Fate

  Chlorobenzene's production and use as a chemical intermediate, solvent, and heat transfer medium may result in its release to the environment through various waste streams. If released to air, chlorobenzene will exist solely as a vapor in the atmosphere. Photochemically produced hydroxyl radicals will ultimately degrade vapor-phase chlorobenzene in less than 24h.
  Biological. In activated sludge, 31.5% of the applied chlorobenzene mineralized to carbon dioxide after 5 d (Freitag et al., 1985). A mixed culture of soil bacteria or a Pseudomonas sp. transformed chlorobenzene to chlorophenol (Ballschiter and Scholz, 1980). Pure microbial cultures isolated from soil hydroxylated chlorobenzene to 2- and 4-chlorophenol (Smith and Rosazza, 1974). Chlorobenzene was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum. At a concentration of 5 mg/L, biodegradation yields at the end of 1 and 2 wk were 89 and 100%, respectively. At a concentration of 10 mg/L, significant degradation with gradual adaptation was observed.Complete degradation was not observed until after the 3rd week of incubation (Tabak et al.,1981).
  https://www.epa.gov

• Lager

  Color Code—Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.Prior to working with chlorobenzene you should be trainedon its proper handling and storage. Before entering confinedspace where this chemical may be present, check to makesure that an explosive concentration does not exist.Chlorobenzene must be stored to avoid contact with strongoxidizers (such as chlorine, bromine, and fluorine), sinceviolent reactions occur. Store in tightly closed containers ina cool, well-ventilated area away from heat, sparks, orflames. Sources of ignition, such as smoking and openflames are prohibited where Chlorobenzene is used, handled, or stored in a manner that could create a potential fireor explosion hazard. Metal containers involving the transferof=gallons or more of Chlorobenzene should be groundedand bonded. Drums must be equipped with self-closingvalves, pressure vacuum bungs, and flame arresters. Useonly nonsparking tools and equipment, especially whenopening and closing containers of Chlorobenzene.

• Versand/Shipping

  UN1134 Chlorobenzene, Hazard Class: 3; Labels: 3-Flammable liquid.

• läuterung methode

  The main impurities are likely to be chlorinated impurities originally present in the *benzene used in the synthesis of chlorobenzene, and also unchlorinated hydrocarbons. A common purification procedure is to wash it several times with conc H2SO4 then with aqueous NaHCO3 or Na2CO3, and water, followed by drying with CaCl2, K2CO3 or CaSO4, then with P2O5, and distilling. It can also be dried with Linde 4A molecular sieve. Passage through, and storage over, activated alumina has been used to obtain low conductance material. [Flaherty & Stern J Am Chem Soc 80 1034 1958, Beilstein 5 H 199, 5 IV 640.]

• Toxicity evaluation

  In the ambient atmosphere, chlorobenzene will exist as a vapor, and will be degraded by reaction with photochemically produced hydroxyl radicals, with an estimated half-life of 21 days. It can be removed from the air by rain. Photolysis halflives of 4–18 h were measured in aqueous media. If released to soil, chlorobenzene is expected to have very high to moderate mobility based on a Koc range of 4.8–313. Moist soil surfaces will favor volatilization based upon Henry’s Law constant of 3.11×10³ atm-cu m mol^-1. Chlorobenzene may volatilize from dry soil surfaces as well. If released into water, chlorobenzene may adsorb to suspended solids and sediment based on the Koc values. Volatilization from water surfaces is expected to be an important fate process based on this compound’s Henry’s Law constant. Estimated volatilization half-lives for a model river and model lake are 3.4 h and 4.3 days, respectively. Reported bioconcentration in aquatic organisms is low to high, provided the compound is not metabolized by the organism. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Biodegradation results are variable based on soil type and microbial diversity. In river water, the biodegradation half-life was reported to be 150 and 75 days in the sediment.

• Inkompatibilitäten

  Reacts violently with strong oxidizers; dimethyl sulfoxide; sodium powder; silver perchlorate; causing fire and explosion hazard. Attacks some plastics, rubber, and coatings. Decomposes on heating, producing phosgene and hydrogen chloride fumes.

• Waste disposal

  Incineration, preferably after mixing with another combustible fuel; care must be exercised to assure complete combustion to prevent the formation of phosgene; an acid scrubber is necessary to remove the halo acids produced.

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