(o-(-2,6-Dichloranilino)phenyl)-essigsäure, Natrium-Salz Produkt Beschreibung

Diclofenac sodium Struktur
15307-79-6
  • CAS-Nr.15307-79-6
  • Bezeichnung:(o-(-2,6-Dichloranilino)phenyl)-essigsäure, Natrium-Salz
  • Englisch Name:Diclofenac sodium
  • Synonyma:Natrium-[2-[(2,6-dichlorphenyl)amino]phenyl]acetat;(o-(-2,6-Dichloranilino)phenyl)-essigsäure, Natrium-Salz
    Naclof;Voldal;KROPLEX;Diacron;gp45840;kriplex;ortofen;VALETAN;BENFOFEN;Naclofen
  • CBNumber:CB5474464
  • Summenformel:C14H10Cl2NNaO2
  • Molgewicht:318.13
  • MOL-Datei:15307-79-6.mol
(o-(-2,6-Dichloranilino)phenyl)-essigsäure, Natrium-Salz physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :288-290°C
  • Dichte :0.781 g/cm3
  • storage temp.  :room temp
  • Löslichkeit :H2O: 50 mg/mL
  • pka :4(at 25℃)
  • Aggregatzustand :White solid
  • Wasserlöslichkeit :Soluble in water to 50mg/ml.
  • Merck  :14,3081
  • Stabilität: :Stable.
  • InChIKey :KPHWPUGNDIVLNH-UHFFFAOYSA-M
  • CAS Datenbank :15307-79-6(CAS DataBase Reference)
Sicherheit
  • Kennzeichnung gefährlicher :T,Xi
  • R-Sätze: :25-36/37/38-63
  • S-Sätze: :22-36/37-45-36-26-60-20
  • RIDADR  :UN 2811 6.1/PG 3
  • WGK Germany  :3
  • RTECS-Nr. :AG6330000
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • HS Code  :29224999
  • Toxizität :LD50 in mice, rats (mg/kg): ~390, 150 orally (Krupp)

Diclofenac sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R25:Giftig beim Verschlucken.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  • S-Sätze Betriebsanweisung: S22:Staub nicht einatmen.
    S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  • Chemische Eigenschaften Off-White Crystalline Solid
  • Originator Voltaren,Fujisawa,Japan,1974
  • Verwenden A nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor.
  • Verwenden A nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor
  • Verwenden An inhibitor of Cox-1 and Cox-2.
  • Definition ChEBI: The sodium salt of diclofenac.
  • Manufacturing Process Four grams of N-chloroacetyl-N-phenyl-2,6-dichloroaniline and 4 grams of aluminum chloride are well mixed together and heated for 2 hours at 160°C. The melt is cooled and poured onto about 50 grams of ice while it is still warm. The oil which separates is dissolved in 50 ml of chloroform, the chloroform solution is washed with 10 ml of water, dried over sodium sulfate and concentrated under 11 torr. The residue is distilled. The 1-(2,6- dichlorophenyl)-2-indolinone melts at 126°-127°C.
    A solution of 186 grams of 1-(2,6-dichlorophenyl)-2-indolinone in 660 ml of ethanol and 660 ml of 2 N sodium hydroxide solution is refluxed for 4 hours. The solution is then cooled and left to stand for 4 hours at 0°-5°C. The crystals which form are filtered off and recrystallized from water. The sodium salt of 2-(2,6-dichloroanilino)-phenylacetic acid melts at 283°-285°C. The yield is 97% of theoretical, according to US Patent 3,558,690.
  • Trademarks Solaraze (Bioglan); Voltaren (Novartis);Aflamin;Alfamin;Allvoran;Artren;Blesin;B-voltaren;Cgp 9194;Chlorgyl;Ct-diclo;Dichloronic;Diclo attritin;Diclo spondril;Diclo-attritin;Diclo-burg;Diclo-phlohont;Diclo-puren;Diclo-recip;Dicloreum;Diclo-spondyril;Diclo-wolf;Dolobasan;Dolotrem;Doragon;Duravolten;Duvavotten;Feloran;Fenoflam;Flogofenac;Flogogenac;Forgenac;Inflamac;Klast;Monoflam;Myogit;Neuro-effekton;Neurofenac;Neuro-voltaren;Neviodin;Olfen;Panamor;Rewodina;Rheumalgen;Rheumavincin-n;Seecoren;Shignol;Silino;Sofarin;Thicataren;Toryxil;Tsudomin;Voltarene.
  • Therapeutic Function Antiinflammatory
  • Weltgesundheitsorganisation (WHO) The World Health Organization currently has no information to suggest that diclofenac is less safe than other widely available non-steroidal antiinflammatory substances of this type, or that children are particularly liable to react adversely. It is registered in many countries in several dosage forms, including a 12.5 mg suppository indicated for juvenile arthritis.
  • Clinical Use Diclofenac sodium is indicated for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
  • Veterinary Drugs and Treatments The equine topical cream (Surpass?) is labeled for the control of pain and inflammation associated with osteoarthritis in tarsal, carpal, metacarpophalangeal, metarsophalangeal, and proximal interphalangeal (hock, knee, fetlock, pastern) joints for use up to 10 days duration. While, theoretically, diclofenac could be used systemically (orally) in other veterinary species, there are approved and safer alternatives.
Diclofenac sodium Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(o-(-2,6-Dichloranilino)phenyl)-essigsäure, Natrium-Salz Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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15307-79-6, Diclofenac sodium Verwandte Suche:
  • N-(2,6-Dichlorophenyl)-o-aminophenylacetic acid sodium salt
  • sodium(o-((2,6-dichlorophenyl)amino)phenyl)acetate
  • sodium(o-(2,6-dichloroanilino)phenyl)acetate
  • sodiumdiclofenac
  • tsudohmin
  • AKOS B020028
  • 2-(2,6-DICHLOROANILINO)PHENYLACETIC ACID SODIUM SALT
  • 2-[(2,6-DICHLOROPHENYL)AMINO]-BENZENEACETIC ACID MONOSODIUM SALT
  • 2-[(2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, NA
  • 2-[(2,6-DICHLOROPHENYL)AMINO]-BENZENEACETIC ACID SODIUM SALT
  • KROPLEX
  • BENFOFEN
  • Diclofenac Sodium 15307-79-6
  • 2-((2,6-dichlorophenyl)amino)benzeneacetic acid monosodium salt,dichronic,diclofenac sodium
  • diclofenac sodiume
  • Extract of cuttlebone
  • Diclofenac sodium, 98%, a non-selective COX inhibitor
  • Aceclofenac Impurity 1(Aceclofenac EP Impurity A)
  • Mulberry octopus extract
  • Diclofenac Sodium - CAS 15307-79-6 - Calbiochem
  • sodium 2-[2-(2,6-dichloroanilino)phenyl]acetate
  • Diclofenac sodium Manufacturer
  • 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium
  • OOTHECA MANTIDIS
  • Diclofenac SodiuM EC pellets 32%
  • DelphiMix
  • Diacron
  • Naclof
  • Naclofen
  • Novapirina
  • Orthofen
  • SorelMon
  • Voldal
  • Voltaren Ophtha
  • Diclofenac sodiuM COS
  • 2-(2,6-Dichloroanilino)phenylacetic Acid Sodium Salt Sodium 2-(2,6-Dichloroanilino)phenylacetate
  • Diclofenac SodiuM SR pellets 32%
  • Diclofenac SodiuM(EP/BP)
  • Aceclofenac EP IMpurity A
  • sodiuM 2-(2-((2,6-dichlorophenyl)aMino)phenyl)acetate
  • Diclofenac Sodium (200 mg)
  • Solaraze
  • (o-(2,6-dichloroanilino)phenyl)aceticacidmonosodiumsalt
  • (o-(2,6-dichloroanilino)phenyl)aceticacidsodiumsalt
  • 2-((2,6-dichlorophenyl)amino)-benzeneaceticacimonosodiumsalt
  • 2-[(2,6-Dichlorophenyl)amino]benzeneaceticacidsodiumslat
  • 2[(2,6-dichlorophenyl)amino]-benzeneaceticacimonosodium
  • diclophenacsodium
  • gp45840
  • huma-difenac
  • kriplex
  • o-(2,6-dichloroanilino)phenyl-aceticacimonosodiumsalt
  • orthophen
  • ortofen
  • prophenatin
  • 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid,sodium salt (1:1)
  • 51.75/KG
  • Diclofenac for system suitability