Sulfaguanidin

Bezeichnung:Sulfaguanidin

CAS-Nr57-67-0

Englisch Name:Sulfaguanidine

CBNumberCB7152799

SummenformelC7H10N4O2S

Molgewicht214.24

MOL-Datei57-67-0.mol

Synonyma

Sulfaguanidin

Sulfaguanidin physikalisch-chemischer Eigenschaften

Schmelzpunkt	190-193°C
Siedepunkt	426.1±47.0 °C(Predicted)
Dichte	1.3916 (rough estimate)
Brechungsindex	1.6440 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	1 M HCl: soluble50mg/mL
Aggregatzustand	Powder
pka	pKa 2.37(H2O t = 37) (Uncertain)
Farbe	white to off-white
Wasserlöslichkeit	1g/1000mL at 25 ºC
Merck	14,8908
BRN	2695326
Stabilität	Stable. Incompatible with strong oxidizing agents.
CAS Datenbank	57-67-0(CAS DataBase Reference)
NIST chemische Informationen	Sulfaguanidine(57-67-0)
EPA chemische Informationen	Benzenesulfonamide, 4-amino-N-(aminoiminomethyl)- (57-67-0)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
RIDADR	3249
WGK Germany	3
RTECS-Nr.	WO8575000
F	10
HazardClass	6.1(b)
PackingGroup	III
HS Code	29350090

Gefahreninformationscode (GHS)

Sulfaguanidine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
white powder
Originator
Sulfaguanidine,Lederle,US,1941
Verwenden
Sulfonamide antibacterial.
Verwenden
Sulfaguanidine is a sulfonamide based antibiotic drug with potential application in veterinary medicine.
Definition
ChEBI: Sulfaguanidine is a sulfonamide incorporating a guanidine moiety used to block the synthesis of folic acid; mostly used in veterinary medicine It has a role as an antiinfective agent.
Manufacturing Process
10 parts of guanidine hydrochloride (0.1 mol) was dissolved in 75 parts of water and the pH adjusted to 8 to 9. The solution was warmed to 50°C to 60°C and kept at this temperature while a slurry of 25 parts (0.113 mol) of pnitrobenzenesulfonyl chloride was added slowly with mechanical stirring. The pH was kept at 8 to 9 by the addition of 40% sodium hydroxide solution. At the end of the reaction the solution was cooled and filtered from the separated solid. The p-nitrobenzene sulfonyl guanidine was recrystallized from hot water.
5 parts (0.024 mol) of p-nitrobenzene sulfonyl guanidine was dissolved in 50 parts of boiling 95% alcohol and to the solution was added 0.5 part of concentrated hydrochloric acid. The solution was heated to reflux and 6 parts of iron dust was added. The suspension was refluxed for 3 hours, made basic with potassium carbonate, and filtered hot. The alcohol was evaporated off and the p-aminobenzene sulfonyl guanidine recrystallized from boiling water with the addition of decolorizing charcoal.
Trademarks
Aseptil-guanidina;Coliseptale;Devaguanil;Dirkan;Emerin;Ente-rivo simplex;Granidan;Guamide;Guanicil;Guanimycin;Guanowept;Guasept;Inorgan;Intestovet;Ordenol;Orgaguanidon;Resulfon;Ruocil;Sgd;S-guanidan;S-guanidine;Shigatox;Suganyl;Sulfacarbon;Sulfentidine;Sulfogua;Tetrawest;Trisulvet.
Therapeutic Function
Antimicrobial
Weltgesundheitsorganisation (WHO)
Sulfaguanidine, a sulfonamide anti-infective agent, was introduced in 1941 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Although sulfaguanidine, which is poorly absorbed from the gastrointestinal tract, is no longer recommended in some countries, it continues to be used in others for the treatment of local intestinal infections, including bacterial dysentery, and for preoperative bowel preparation.
Pharmazeutische Anwendungen
1-Sulfanilylguanidine. A poorly absorbed compound, less potent than succinylsulfathiazole but with similar uses. Blood concentrations of 15–40 mg/L have been found after single doses of 1–7 g. Excretion in the urine is rapid.
Sicherheitsprofil
Moderately toxic by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. See also SULFONATES. When heated to decomposition it emits very toxic fumes of SO, and NO,.
läuterung methode
Crystallise the antibacterial from hot water (7mL/g). [Beilstein 14 III 1970, 14 IV 2668.]

Sulfaguanidine Upstream-Materialien And Downstream Produkte

Sulfaguanidin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

57-67-0, Sulfaguanidine Verwandte Suche:

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