Sulfadimidin Produkt Beschreibung

Sulfamethazine Struktur
57-68-1
  • CAS-Nr.57-68-1
  • Bezeichnung:Sulfadimidin
  • Englisch Name:Sulfamethazine
  • Synonyma:Sulfadimidin
    SM2;L-30;A-502;saiii;S-Mez;Diazi;bn2409;Diazil;Sa III;Mermeth
  • CBNumber:CB8116727
  • Summenformel:C12H14N4O2S
  • Molgewicht:278.33
  • MOL-Datei:57-68-1.mol
Sulfadimidin physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :197 °C
  • Siedepunkt: :294°C (rough estimate)
  • Dichte :1.2997 (rough estimate)
  • Brechungsindex :1.6440 (estimate)
  • storage temp.  :2-8°C
  • Löslichkeit :acetone: soluble50mg/mL
  • Aggregatzustand :Crystalline Powder
  • pka :7.4, 2.65(at 25℃)
  • Farbe :white to off-white
  • Wasserlöslichkeit :150mg/100mL (29 ºC)
  • Merck  :14,8905
  • BRN  :261304
  • Stabilität: :Stable, but light sensitive. Incompatible with strong oxidizing agents.
  • CAS Datenbank :57-68-1(CAS DataBase Reference)
  • NIST chemische Informationen :Sulfamethazine(57-68-1)
  • EPA chemische Informationen :Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2- pyrimidinyl)-(57-68-1)
Sicherheit

Sulfamethazine Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  • S-Sätze Betriebsanweisung: S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
    S24/25:Berührung mit den Augen und der Haut vermeiden.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  • Chemische Eigenschaften White to Off-Solid
  • Verwenden Antibacterial
  • Definition ChEBI: A sulfonamide consisting of pyrimidine with methyl substituents at the 4- and 6-positions and a 4-aminobenzenesulfonamido group at the 2-position.
  • Trademarks Calfspan Tablets [Veterinary] (Fort Dodge Animal Health); Sulka S Boluses [Veterinary] (Fort Dodge Animal Health); SulfaSURE SR Bolus [Veterinary] (Boehringer Ingelheim Animal Health);Crermomethazine;Deladine;Dimezathine;Hava-span;Intradin;Neotrizine;Rigesol;Rivodin;S-dimidine;Spanbolet;Sulka-s;Sulphamezathine;Sulphfmezatine;Superseptyl;Sustain iii;Tersulpha;Trisulfaminic;Trisulfaminie.
  • Weltgesundheitsorganisation (WHO) Sulfadimidine, a sulfonamide anti-infective agent, was introduced in 1942 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Sulfadimidine is still used in some countries as a injectable or oral antimicrobial for susceptible infections.
  • Allgemeine Beschreibung Sulfamethazine’splasma half-life is 7 hours. This compound is similar inchemical properties to sulfamerazine and sulfadiazine butdoes have greater water solubility than either. Its pKa is 7.2.Because it is more soluble in acid urine than sulfamerazineis, the possibility of kidney damage from use of the drug isdecreased. The human body appears to handle the drugunpredictably; hence, there is some disfavor to its use in thiscountry except in combination sulfa therapy (in trisulfapyrimidines,USP) and in veterinary medicine.
  • Allgemeine Beschreibung Odorless sticky, white or creamy-white crystalline powder. Slightly bitter taste. An antibacterial.
  • Air & Water Reaktionen Water solubility increases rapidly with increasing pH [Merck]. Insoluble in water.
  • Reaktivität anzeigen Sulfamethazine is sensitive to light and may also be sensitive to heat. The presence of oxygen and moisture may accelerate the effects of heat and light .
  • Brandgefahr Flash point data for Sulfamethazine are not available; however, Sulfamethazine is probably combustible.
  • Pharmazeutische Anwendungen 2-Sulfanilamido-4,6-methylpyrimidine (syn: sulphamethazine, sulfamezathine). A water-soluble compound, unstable on exposure to light. It is usually administered by mouth and is a component of some triple sulfonamide combinations.
    The spectrum is typical of the group, but sulfadimidine exhibits relatively low potency. It is well absorbed after oral administration. It is extensively metabolized, predominantly by acetylation. The mean plasma half-life (1.5–5 h) varies with acetylator status.
    In addition to side effects common to the group, a serious interaction between ciclosporin (cyclosporin A) and sulfadimidine, leading to reduced ciclosporin levels, has been reported.
  • Sicherheitsprofil Moderately toxic by intravenous and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of SOx and NOx.
  • läuterung methode Crystallise it from dioxane or aqueous dioxane. [Caldwell et al. J Am Chem Soc 63 2188 1941, Roblin et al. J Am Chem Soc 64 567 1942, Beilstein 25 III/IV 2215.]
Sulfamethazine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Sulfadimidin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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57-68-1, Sulfamethazine Verwandte Suche:
  • (p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin
  • 2-(4-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine
  • 4,6-Dimethyl-2-sulfanilamidopyrimidine
  • 4-Amino-N-(2,6-dimethyl-2-pyrimidinyl)ben-zenesulfonamide
  • 4-amino-n-(4,6-dimethyl-2-pyrimidinyl)-benzenesulfonamid
  • 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-Benzensulfonamide
  • 4-amino-N-(4,6-dimethyl-2-pyrimiidinyl)benzenesulfonamide
  • 6-(4’-aminobenzol-sulfonamido)-2,4-dimethylpyrimidin
  • 6-(4'-Aminobenzol-sulfonamido)-2,4-dimethylpyrimidin
  • A-502
  • Azolmetazin
  • Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-
  • benzenesulfonamide,4-amino-N-(4,6-dimethyl-2-pyrimiidinyl)-
  • Benzensulfonamide,4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-
  • bn2409
  • Calfspan tablets
  • Cremomethazine
  • Diazil
  • Diazilsulfadine
  • Dimezathine
  • Dimidim-R
  • Dimidin-R
  • Hava-Span
  • Intradine
  • Kelametazine
  • L-30
  • Mermeth
  • Metazin
  • n(1)-(4,6-dimethyl-2-pyrimidinyl)-sulfanilamid
  • n(1)-(4,6-dimethyl-2-pyrimidyl)sulfanilamide
  • N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
  • N(sup1)-(2,6-Dimethylpyrimid-4-yl)sulfanilamide
  • Sulfodimezine
  • Sulka k boluses
  • Sulphadimethylpyrimidine
  • Sulphadimidine
  • Sulphamethasine
  • Sulphamethazine
  • Sulphamezathine
  • Sulphamidine
  • Sulphix
  • Sulphodimezine
  • Superseptil
  • Superseptyl
  • Vertolan
  • Zinosan N
  • 2-sulfanilamido-4,6-dimethylpyrimidine
  • 2-(p-aminobenzenesulfonamido)-4,6-dimethylpyrimidine
  • AKOS B015995
  • 4,6-DIMETHYLSULFADIAZINE
  • 4-AMINO-N-(4,6-DIMETHYL-PYRIMIDIN-2-YL)-BENZENESULFONAMIDE
  • 4-AMINO-N-(4,6-DIMETHYL-2-PYRIMIDINYL)BENZENESULFONAMIDE
  • LABOTEST-BB LT00114898
  • SulfadiMidine COS
  • Sulfadimidine 4-Amino-N-(4,6-dimethyl-2-pyrimidyl)benzenesulfonamide 4,6-Dimethylsulfadiazine
  • SulfaMethazine, 98.0%(LC&T
  • SulfaMethazin
  • Sulfadimidine[1]