Guanidiniumchlorid

Bezeichnung:Guanidiniumchlorid

CAS-Nr50-01-1

Englisch Name:Guanidine hydrochloride

CBNumberCB6677329

SummenformelCH5N3.ClH

Molgewicht95.53

MOL-Datei50-01-1.mol

Synonyma

Guanidiniumchlorid

Aminoformamidinhydrochlorid

Aminomethanamidinhydrochlorid

Guanidiniumchlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	180-185 °C(lit.)
Dichte	1.18 g/mL at 25 °C(lit.)
Brechungsindex	n20/D 1.465
storage temp.	room temp
Löslichkeit	H₂O: 6 M, clear, colorless
Aggregatzustand	Crystals
Farbe	White to slightly yellow
Geruch (Odor)	Odorless
Säure-Base-Indikators(pH-Indikatoren)	4.5 - 6.0 at 573 g/l at 25 °C
PH	4.5-5.5 (100g/l, H2O, 20℃)
Wasserlöslichkeit	2280 g/L (20 ºC)
Sensitive	Hygroscopic
maximale Wellenlänge (λmax)	λ: 260 nm Amax: 0.040 λ: 280 nm Amax: 0.025
Merck	14,4562
BRN	3591990
Stabilität	Stable. Hygroscopic. Incompatible with strong oxidizing agents.
InChIKey	PJJJBBJSCAKJQF-UHFFFAOYSA-N
CAS Datenbank	50-01-1(CAS DataBase Reference)
EPA chemische Informationen	Guanidine monohydrochloride (50-01-1)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/38
S-Sätze:	26-36-22
WGK Germany	1
RTECS-Nr.	MF4300000
F	3-10
TSCA	Yes
HS Code	29252000
Toxizität	LD50 orally in Rabbit: 655.3 - 907.1 mg/kg LD50 dermal Rabbit > 2000 mg/kg

Gefahreninformationscode (GHS)

Guanidine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
HYGROSKOPISCHES KRISTALLINES PULVER.
CHEMISCHE GEFAHREN
Beim Verbrennen Bildung giftiger und ätzender Rauche mit Chlorwasserstoffund Stickstoffoxiden. Schwache Säure in wässriger Lösung.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Verschlucken.
INHALATIONSGEFAHREN
Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Dispergieren schnell erreicht werden.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Augenund die Haut.
LECKAGE
Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste mit viel Wasser wegspülen. Persönliche Schutzausrüstung: Atemschutzgerät, P2-Filter für schädliche Partikel.
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/38:Reizt die Augen und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S22:Staub nicht einatmen.
Aussehen Eigenschaften
CH6ClN3; Aminomethanamidinhydrochlorid, Carbamidinhydrochlorid. Farblose, fast geruchlose Kristalle, gut in Wasser löslich.
Gefahren für Mensch und Umwelt
Spaltet bei höheren Temperaturen HCl ab. Gesundheitsschädlich beim Verschlucken. Reizt die Augen und Schleimhäute beim Einatmen.
Schutzmaßnahmen und Verhaltensregeln
Bei 15 - 25鳦 trocken lagern (hygroskopisch).
Schutzhandschuhe als kurzzeitiger Staubschutz.
#
Verhalten im Gefahrfall
Trocken aufnehmen. Der Entsorgung zuführen. Mit Wasser nachreinigen.
Wasser im Sprühstrahl, Kohlendioxid, Pulver, Schaum.
Im Brandfall können Chlorwasserstoff und nitrose Gase entstehen.
Erste Hilfe
Nach Hautkontakt: Mit reichlich Wasser abwaschen.
Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 10 Minuten ausspülen.
Nach Einatmen: Frischluft.
Nach Verschlucken: Viel Wasser trinken lassen, Erbrechen auslösen, Arzt hinzuziehen. Atemwege freihalten.
Nach Kleidungskontakt: Kontaminierte Kleidung sofort ausziehen.
Ersthelfer: siehe gesonderten Anschlag
Sachgerechte Entsorgung
In Wasser lösen, neutralisieren, dann in wässrige neutrale Lösemittelabfälle.
Chemische Eigenschaften
Guanidine hydrochloride, a strong organic base, appears as white crystal powder or yellowish lumps that are almost insoluble in acetone, benzene, and ether. In physiological pH, it exists primarily as guanidium ions. It is a natural byproduct of protein metabolism found in urine and is commonly used in protein denaturation in laboratory research.
Verwenden
Guanidine has a good bacterial and fungicidal efficacy when used in low concentration and can also be used as disinfectant.
Verwenden
Guanidine hydrochloride is used for purification of proteins and nucleic acids. It can be used as a medicine, organic synthesis intermediate and is used in dyes. It acts as an intermediate in the preparation of sulfadiazine, which is an important raw material for sulfamethyldiazine, sulfamethazine and folic acid. It is utilized in the synthesis of 2-amino-pyrimidine, 2- amino -6- methyl-pyrimidine and 2-amino -4,6 - dimethyl-pyrimidine. Also used in RNA isolation to dissociate nucleoproteins and inhibit RNase.
Definition
ChEBI: Guanidine Hydrochloride is an aminocarboxamidine, the parent compound of the guanidines. It is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism.
Application
Guanidine hydrochloride can be used as pharmaceuticals, pesticides, dyes and other organic synthesis intermediates. It can be used to synthesize 2-aminopyrimidine, 2-amino-6-methylpyrimidine, 2-amino-4,6-dimethylpyrimidine, and is used for the manufacture of sulfadiazine, sulfamethazine, sulfamethazine and other sulfa drugs. Intermediate. Guanidine hydrochloride (or guanidine nitrate) reacts with ethyl cyanoacetate to form 2,4-diamino-6-hydroxypyrimidine, which is used to synthesize the anti-anemia drug folic acid. It can also be used as an antistatic agent for synthetic fibers. Can also be used for protein denaturants. As a strong denaturant in experiments for extracting total cellular RNA[3]. The guanidine hydrochloride solution can dissolve the protein, leading to the destruction of the cell structure, the destruction of the secondary structure of the nucleoprotein, and the dissociation from the nucleic acid. In addition, the RNase can be inactivated by reducing agents such as guanidine hydrochloride.
synthetische
The process for preparing guanidine hydrochloride is as follows:
Step 1: Fritting - Combine dicyandiamide and ammonium chloride in a reactor with a 1:1.27 weight ratio and carry out a frit reaction at 170-230°C to obtain crude guanidine hydrochloride.
Step 2: Dissolving - Dissolve the crude guanidine hydrochloride in water at a 1:1 ratio at normal temperature. Then, add ammonium salt alkaloid in an amount determined by the ammonium salt content in the crude guanidine hydrochloride.
Step 3: Filtering - Remove raw materials and reaction by-products with filtration.
Step 4: Dehydrating - Dehydrate the filtered ground mother liquor at a high temperature.
Step 5: Crystallizing - Cool the supersaturated solution, concentrate, and crystallize to obtain high-purity guanidine hydrochloride.
Step 6: Repeat steps 2-5 and add dicyandiamide in the reactor with the guanidine hydrochloride to carry out frit reaction at 170-230°C for 3-4 hours to obtain even higher purity guanidine hydrochloride. This step can be repeated several times if needed.
Step 7: To obtain higher purity guanidine hydrochloride, subject the guanidine hydrochloride obtained in step 5 to steps 2-5 again, with the water ratio in step 2 adjusted to 1.5:1. This step can be repeated numerous times as required.
Allgemeine Beschreibung
Guanidine hydrochloride (GdnHCl) is a well-known protein and enzyme denaturant. It is a small molecule and hydroscopic in nature. It is used to synthesis medicine, pesticide, dye and other organic compound, is the important material to make sulfanilamide medicine and folacin, and can be used as anti-static agent of compound fibre.
Hazard
Toxic by ingestion, evolves hydrogen chloride fumes on heating.
Biochem/physiol Actions
Guanidine hydrochloride (GdnHCl) is involved in conformational changes and loss of enzyme activity due to inactivation of the enzyme. It is involved in the loss of activity of alkaline phosphatase (ALPase) enzyme in Haliotis diversicolor. GdnHCl functions by hampering the activity of heat shock protein 104 (Hsp104) adenosine triphosphatase (ATPase) in vivo. It can also inactivate enzymes like papain and aminocyclase. Higher concentrations of GdnHCl leads to viral inactivation of herpes simplex virus 1 (HSV-1).
läuterung methode
Crystallise the hydrochloride from hot methanol by chilling to about -10o, with vigorous stirring. The fine crystals are filtered through fritted glass, washed with cold (-10o) methanol, dried at 50o under vacuum for 5hours. (The product is purer than that obtained by crystallisation at room temperature from methanol by adding large amounts of diethyl ether.) [Kolthoff et al. J Am Chem Soc 79 5102 1957, Beilstein 3 H 86, 3 II 71, 3 III 160, 3 IV 150.]

Guanidine hydrochloride Upstream-Materialien And Downstream Produkte

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