2-Brommethyl-1,3-dioxolan

Bezeichnung:2-Brommethyl-1,3-dioxolan

Englisch Name:2-Bromomethyl-1,3-dioxolane

CBNumberCB5344956

SummenformelC4H7BrO2

Molgewicht167

Synonyma

2-Brommethyl-1,3-dioxolan

2-Brommethyl-1,3-dioxolan physikalisch-chemischer Eigenschaften

Siedepunkt	80-82 °C27 mm Hg(lit.)
Dichte	1.613 g/mL at 25 °C(lit.)
Brechungsindex	n20/D 1.482(lit.)
Flammpunkt	145 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Chloroform, Ethyl Acetate (Slightly)
Aggregatzustand	Liquid
Farbe	Clear colorless
Wasserlöslichkeit	Immiscible with water.
Sensitive	Moisture Sensitive
BRN	103309
InChI	1S/C4H7BrO2/c5-3-4-6-1-2-7-4/h4H,1-3H2
InChIKey	CKIIJIDEWWXQEA-UHFFFAOYSA-N
SMILES	BrCC1OCCO1
CAS Datenbank	4360-63-8(CAS DataBase Reference)
NIST chemische Informationen	2-Bromomethyl-1,3-dioxolane(4360-63-8)
EPA chemische Informationen	1,3-Dioxolane, 2-(bromomethyl)- (4360-63-8)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-24/25
WGK Germany	3
TSCA	TSCA listed
HS Code	29049090
Speicherklasse	10 - Combustible liquids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2

Gefahreninformationscode (GHS)

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
clear colorless liquid
Verwenden
2-Bromomethyl-1,3-dioxolane was used in the synthesis of 1,4-benzoxazepine (BZO) compounds.
Verwenden
2-Bromomethyl-1,3-dioxolane is used in the preparation of alfa, beta-unsaturated aldehyde and 1, 4-two aldehyde monoacetals synthesis of monomers.
Synthese

107-21-1

75-07-0

4360-63-8

10.326 kg (166.3 mol) of ethylene glycol and 3.66 kg (83.185 mol) of freshly distilled acetaldehyde were added to the reaction vessel with slow stirring at room temperature for 30 minutes. Slowly 14.622 kg (91.504 mol) of bromine was added dropwise, with the rate of dropwise acceleration being controlled to maintain the reaction temperature at 0-3 °C. After the dropwise addition was completed, the reaction was continued at 0-3 °C for 3.5 hours. Upon completion of the reaction, decompression distillation was carried out to collect the fraction at 80-82 °C/3.6 kPa to give 11.002 kg (65.883 mol) of 2-bromomethyl-1,3-dioxolane in 79.2% yield, which was analyzed to be greater than 95%.
Einzelnachweise
[1] Patent: CN105418612, 2016, A. Location in patent: Paragraph 0028; 0039; 0040

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