Doxofyllin

Bezeichnung:Doxofyllin

CAS-Nr69975-86-6

Englisch Name:Doxofylline

CBNumberCB9265231

SummenformelC11H14N4O4

Molgewicht266.25

MOL-Datei69975-86-6.mol

Synonyma

Doxofyllin

Doxofyllin physikalisch-chemischer Eigenschaften

Schmelzpunkt	144-146°C
Siedepunkt	409.46°C (rough estimate)
Dichte	1.2896 (rough estimate)
Brechungsindex	1.6000 (estimate)
RTECS-Nr.	XH5135000
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	0.42±0.70(Predicted)
Farbe	White to Off-White
Wasserlöslichkeit	Soluble
Merck	14,3438
InChI	InChI=1S/C11H14N4O4/c1-13-9-8(10(16)14(2)11(13)17)15(6-12-9)5-7-18-3-4-19-7/h6-7H,3-5H2,1-2H3
InChIKey	HWXIGFIVGWUZAO-UHFFFAOYSA-N
SMILES	N1(CC2OCCO2)C2=C(N(C)C(=O)N(C)C2=O)N=C1
CAS Datenbank	69975-86-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36/37
HS Code	29399990
Toxizität	LD50 in mice (mg/kg): 841 orally; 215.6 i.v.; in rats: 1022.4 orally, 445 i.p. (Franzone)

Gefahreninformationscode (GHS)

Doxofylline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Doxofylline, a xanthine bronchodilator related to theophylline, is useful in the treatment of asthma and similar bronchospastic disorders. It has minimal activity on intestinal smooth muscle and the cardiovascular system, and is reportedly devoid of the behavioral effects of theophylline.
Beschreibung
Doxofylline is a methylxanthine bronchodilator that has been examined in clinical trials involving patients with either bronchial asthma or chronic obstructive pulmonary disease. Its mechanism of action is related to its ability to inhibit phosphodiesterase activity and, thus, increase cAMP. Compared to other xanthine derivatives, which have direct arrhythmogenic effects, doxofylline demonstrates decreased affinity towards adenosine A₁ and A₂ receptors, does not interfere with calcium influx into cells, and does not antagonize the action of calcium-channel blockers.
Originator
ABC S.p.A. (Italy)
Verwenden
H1 antihistamine
Verwenden
Doxofylline is a xanthine molecule that appears to be both bronchodilator and anti-inflammatory with an improved therapeutic window over conventional xanthines such as Theophylline and the evidence supporting the effects of Doxofylline in the treatment of lung diseases.
Definition
ChEBI: Doxofylline is an oxopurine that is a derivative of xanthine, methylated at N-1 and N-3 and carrying a 1,3-dioxolan-2-ylmethyl group at N-7, used in the treatment of asthma. It has a role as a bronchodilator agent, an antitussive and an anti-asthmatic drug. It is functionally related to a 7H-xanthine.
Trademarks
Maxivent (Roberts Pharmaceutical);ANSIMAR.

Doxofylline Upstream-Materialien And Downstream Produkte

Doxofyllin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

69975-86-6, Doxofylline Verwandte Suche:

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