Aminophyllin

Bezeichnung:Aminophyllin

CAS-Nr317-34-0

Englisch Name:Aminophylline

CBNumberCB8145350

SummenformelC9H16N6O2

Molgewicht240.27

MOL-Datei317-34-0.mol

Synonyma

Aminophyllin

Aminophyllin physikalisch-chemischer Eigenschaften

Schmelzpunkt	269-270 °C
storage temp.	Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	H₂O: 3.7 mg/mL solutions should be freshly prepared.
Aggregatzustand	powder
pka	pKa 5.0 (Uncertain)
Farbe	white to off-white
Wasserlöslichkeit	soluble
Merck	14,465
InChI	InChI=1S/C7H8N4O2.C2H8N2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h3H,1-2H3,(H,8,9);1-4H2
InChIKey	LHRHXWBJUQKYEL-UHFFFAOYSA-N
SMILES	O=C1N(C(=O)N(C)C2NC=NC1=2)C.C(N)CN
LogP	-0.175 (est)
CAS Datenbank	317-34-0(CAS DataBase Reference)
EPA chemische Informationen	1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1) (317-34-0)

Sicherheit

Kennzeichnung gefährlicher	Xn,C
R-Sätze:	22-42/43-34-36/37/38-20/21/22
S-Sätze:	45-36/37/39-26-23-36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	XH5600000
F	10-23
TSCA	Yes
HazardClass	6.1(b)
PackingGroup	III
HS Code	29339900
Giftige Stoffe Daten	317-34-0(Hazardous Substances Data)
Toxizität	LD50 orally in mice: 540 mg/kg (Thompson, Warren)

Gefahreninformationscode (GHS)

Aminophylline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
R34:Verursacht Verätzungen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Aminophylline is a 2/1 mixture of theophylline and ethylenediamine. It caused contact dermatitis in industrial plants, in pharmacists, and in nurses. Ethylenediamine is the sensitizer, and patch testing is generally positive to both ethylenediamine and aminophylline, but negative to theophylline.
Chemische Eigenschaften
white to slightly yellowish powder
Originator
Memcophylline,Memphis Co.
Verwenden
Bronchodilatator;Mastocytes degranulation inhibitor
Verwenden
Aminophylline exhibits vasodilatory and anti-inflammatory activity and is occasionally clinically used to treat chronic obstructive pulmonary disorder (COPD). In animal models of allergen-induced lung inflammation, aminophylline decreases levels of IL-5, IL-8, and eosinophils. It is mostly used to prepare solutions for intravenous injections.
Verwenden
Aminophylline is a bronchodilator and a non-selective phosphodiesterase (PDE) inhibitor.
Definition
ChEBI: Aminophylline is a mixture comprising of theophylline and ethylenediamine in a 2:1 ratio. It has a role as a bronchodilator agent and a cardiotonic drug. It contains a theophylline and an ethylenediamine.
Manufacturing Process
A mixture of 198 g (1 mol) theophylline and 60-78 g (0.75-1 mol) ethylenediamine hydrate in 300 g of water was stirred at 50°C and then the mixture was concentrated in vacuo. The product (aminophylline) was separeted by suction filtration. Aminophylline was used as an aqueous solution.
Trademarks
Phyllocontin (Purdue Frederick); Somophyllin (Fisons); Truphylline (G & W);Afonilum;Aminomal;Aminophylline injection;Aminophylline mudrane;Aminophylline oral;Amino-slow;Amnivent;Asmafilin;Cardophylline;Carine;Colonofilin;Corfilamine;Corophylline;Corphyllamin;Duraphyllin;Escophylline;Eudiamine;Euphyllin 0.48;Euphyllin retard;Euphylllin cr;Euphylllina;Fadfilina;Godafilin;Jaa aminophylline;Mini-lix;Mudrane gg;Mundiphyllin;Palaran;Palaron;Pecram;Pecran;Peterphylin;Phyllotemp;Planphylline;Somophyllin-12;Syntophyllin;Teophyllamin;Thodrox;Variaphylline.
Therapeutic Function
Diuretic, Cardiac stimulant, Smooth muscle relaxant, Vasodilator
Weltgesundheitsorganisation (WHO)
Aminophylline, the ethylenediamine salt of theophylline, was introduced many years ago as a treatment for asthma and is listed in the 8th WHO Model List of Essential Drugs. It has been recognized for some 10 years that aminophylline preparations are not interchangeable because bioavailability can vary considerably. The resulting variability in drug absorption can lead to adverse effects including irritation of the mucosa. Allergic reation can also be an adverse effect of aminophylline. Theophylline functions similarly but is considered less of an irritant.
Hazard
Cardiovascular and respiratory collapse.
Kontakt-Allergie
This drug is a 2:1 mixture of the alkaloid theophylline and ethylenediamine (see below). It caused contact dermatitis in industrial plants, pharmacists, and nurses. Ethylenediamine is the sensitizer and patch testing is generally positive to both ethylenediamine and aminophylline and negative to theophylline.
Clinical Use

Reversible airways obstruction
Acute severe asthma
Veterinary Drugs and Treatments
The theophyllines are used primarily for their bronchodilatory effects, often in patients with myocardial failure and/or pulmonary edema. While they are still routinely used, the methylxanthines must be used cautiously due to their adverse effects and toxicity.
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
Antibacterials: increased concentration with azithromycin, clarithromycin, erythromycin, ciprofloxacin, norfloxacin and isoniazid; decreased erythromycin levels if erythromycin is given orally; increased risk of convulsions if given with quinolones; rifampicin accelerates metabolism of aminophylline.
Antidepressants: concentration increased by fluvoxamine - avoid or halve theophylline dose and monitor levels; concentration reduced by St John’s wort - avoid.
Antiepileptics: metabolism increased by carbamazepine, phenobarbital and primidone; concentration of both drugs increased with fosphenytoin and phenytoin.
Antifungals: concentration increased by fluconazole and ketoconazole.
Antivirals: metabolism of aminophylline increased by ritonavir; concentration possibly increased by aciclovir.
Calcium-channel blockers: concentration increased by diltiazem and verapamil and possibly other calcium-channel blockers.
Deferasirox: concentration of aminophylline increased.
Feboxostat: use with caution.
Interferons: reduced metabolism of aminophylline.
Tacrolimus: may increase tacrolimus levels.
Ulcer-healing drugs: metabolism inhibited by cimetidine; absorption possibly reduced by sucralfate.
Stoffwechsel
Aminophylline is metabolised to theophylline in vivo. Theophylline is excreted in the urine as metabolites, mainly 1,3-dimethyluric acid and 3-methylxanthine, and about 10% is excreted unchanged.

Aminophylline Upstream-Materialien And Downstream Produkte

Aminophyllin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

317-34-0, Aminophylline Verwandte Suche:

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