Lysergid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H225：Flüssigkeit und Dampf leicht entzündbar.

  H319：Verursacht schwere Augenreizung.

  H331：Giftig bei Einatmen.

• Sicherheit

  P210：Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.

  P261：Einatmen von Staub vermeiden.

  P337+P313：Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

  P403+P233：An einem gut belüfteten Ort aufbewahren. Behälter dicht verschlossen halten.

  P403+P235：An einem gut belüfteten Ort aufbewahren. Kühl halten.

Lysergic acid diethylamide Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
  R40:Verdacht auf krebserzeugende Wirkung.
  R36/38:Reizt die Augen und die Haut.
  R23/25:Giftig beim Einatmen und Verschlucken.

• S-Sätze Betriebsanweisung:

  S22:Staub nicht einatmen.
  S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S33:Maßnahmen gegen elektrostatische Aufladungen treffen.
  S24:Berührung mit der Haut vermeiden.
  S16:Von Zündquellen fernhalten - Nicht rauchen.
  S7:Behälter dicht geschlossen halten.

• Beschreibung

  Lysergic acid diethylamide (LSD) is synthetically derived from the fungus, Claviceps purpuria. Several isomers of this compound exist, although only the D-isomer is considered active. LSD was first synthesized by Albert Hofmann in 1938 in a search for an analeptic drug. After finding its psychogenic activity, it was marketed by Sandoz laboratories under the name Delysid. It was also reportedly used by the Central Intelligence Agency as a tool for interrogation. Due to its potential for ‘bad trips,’ ‘flashbacks,’ and potential risk for brain injury, LSD was banned federally in 1966 and is currently only used illicitly. LSD is chemically similar to other naturally occurring lysergamides found in multiple species of morning glory.

• Chemische Eigenschaften

  crystalline solid

• History

  lysergic acid diethylamide(LSD) is a hallucinogenic drug that was first synthesized a Swiss scientist in the 1930s. During the Cold War, the CIA conducted clandestine experiments with LSD (and other drugs) for mind control, information gathering and other purposes. Over time, the drug became a symbol of the 1960s counterculture, eventually joining other hallucinogenic and recreational drugs at rave parties.

• Verwenden

  LSD is obtained by partial synthesis fromD-lysergic acid. It is also produced bymicrobial reaction of Claviceps paspali overthe hydroxylethylamide. It is a well-knownhallucinogen and a drug of abuse, listed asa controlled substance in the U.S. Code ofFederal Regulations (Title 21, Part 1308.11,1987). It is used as an antagonist to serotoninand in the study and treatment of mentaldisorders.

• Verwenden

  Potent hallucinogen; non-selective serotonin receptor agonist. Has been used experimentally as adjunct in study and treatment of mental disorders. Controlled substance.

• Verwenden

  Labelled Lysergide (L488010)

• Definition

  ChEBI: An ergoline alkaloid arising from formal condensation of lysergic acid with diethylamine.

• Allgemeine Beschreibung

  Prismatic crystals (from benzene). Tasteless and odorless. A hallucinogen.

• Reaktivität anzeigen

  An amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

• Health Hazard

  LSD is a strong psychedelic agent. Theeffects in human are excitement, euphoria,hallucinations, and distorted perceptions.It alters the thinking process, producingillusions and loss of contact with reality.In humans, a dose (intramuscular)of 0.7–0.9 mg/kg or an oral dose of2.5–3.0 mg/kg may produce the effectsabove. Other symptoms may include nausea,vomiting, dilation of pupils, restlessness, andperipheral vascoconstriction. However, thereis no reported case of overdose death. In rabbits,somnolence, ataxia, and an increase inbody temperature were the symptoms notedat the LD50 (intravenous) doses at 0.3 mg/kg.
  LD50 value, intravenous (mice): 46 mg/kg
  LD50 value, subcutaneous (guinea pigs):16 mg/kg.

• Brandgefahr

  Flash point data for LSD are not available; however LSD is probably combustible.

• Sicherheitsprofil

  Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. Mutation data reported. Human systemic effects by ingestion and intramuscular routes: euphoria, hallucinations, distorted perceptions, excitement, anorexia, nausea and vomiting. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A much-abused hallucinogen. A federally regulated substance. When heated to decomposition it emits toxic fumes of NOx

• Environmental Fate

  LSD may exist in the air or soil. In the air, LSD may be susceptible to photochemical reactions with subsequently induced radical analogs. Photolysis and oxidative degradation may occur with an airborne half-life of 18 min. LSD’s pKa of 7.8 will have a meaningful percentage of the drug in the cationic form allowing it to interact with soil.

• Toxicity evaluation

  LSD’s mechanism of action is not completely understood. LSD’s hallucinogenic effects are secondary to its ability to increase central serotonin activity. LSD also stimulates both D1 and D2 dopamine receptors.

Lysergic acid diethylamide Upstream-Materialien And Downstream Produkte

50-37-3, Lysergic acid diethylamide Verwandte Suche: