Diethylamin, in wässriger Lösung

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H225：Flüssigkeit und Dampf leicht entzündbar.

  H311：Giftig bei Hautkontakt.

  H314：Verursacht schwere Verätzungen der Haut und schwere Augenschäden.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P210：Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P303+P361+P353：BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Diethylamine Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSE FLüSSIGKEIT MIT STECHENDEM GERUCH.

• PHYSIKALISCHE GEFAHREN

  Die Dämpfe sind schwerer als Luft und können sich am Boden ausbreiten. Fernzündung möglich.

• CHEMISCHE GEFAHREN

  Die Substanz zersetzt sich beim Erhitzen oder beim Verbrennen unter Bildung von giftigen Rauchen mit Stickoxiden. Mittelstarke Base. Reagiert mit starken Oxidationsmitteln, Säuren und organischen Stoffen. Feuer- und Explosionsgefahr. Greift Metall, einige Arten von Kunststoff, Gummi und Beschichtungen an.

• ARBEITSPLATZGRENZWERTE

  TLV: 5 ppm (als TWA), 15 ppm (als STEL) Hautresorption Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2008).
  EG Arbeitsplatz-Richtgrenzwerte: 5 ppm (als TWA), 10 ppm (als STEL) (EU 2002).
  MAK:, 5 ppm 15 mg/m?Spitzenbegrenzung: überschreitungsfaktor I(2); Ein Momentanwert von 10 ml/m?entsprechend 30 mg/m?sollte nicht überschritten werden. Schwangerschaft: Gruppe D (DFG 2008).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation der Dämpfe, über die Haut und durch Verschlucken.

• INHALATIONSGEFAHREN

  Beim Verdampfen bei 20°C kann sehr schnell eine gesundheitsschädliche Kontamination der Luft eintreten.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Substanz verätzt die Augen, die Haut und die Atemwege. ätzend beim Verschlucken. Inhalation kann Lungenödem verursachen, jedoch nur nachdem anfängliche korrossive Effekte auf die Augen und/oder Atemwege aufgetreten sind. Inhalation kann zu Pneumonitis führen. Exposition in hohen Konzentrationen kann zu starker Schwellung im Hals führen. ärztliche Beobachtung notwendig.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Risiko der Lungenschädigung bei wiederholter oder längerer Dampf-Exposition. Möglich sind Auswirkungen auf die Zähne mit nachfolgender Zahnerosion.

• LECKAGE

  Gefahrenbereich verlassen! Persönliche Schutzausrüstung: Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät. Zündquellen entfernen. NICHT in die Umwelt gelangen lassen. NICHT in die Kanalisation spülen. Belüftung. Ausgelaufene Flüssigkeit in abdichtbaren Kunststoff-Behältern sammeln. Reste sorgfältig sammeln. An sicheren Ort bringen.

• R-Sätze Betriebsanweisung:

  R11:Leichtentzündlich.
  R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
  R35:Verursacht schwere Verätzungen.

• S-Sätze Betriebsanweisung:

  S16:Von Zündquellen fernhalten - Nicht rauchen.
  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S29:Nicht in die Kanalisation gelangen lassen.
  S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S3:Kühl aufbewahren.

• Aussehen Eigenschaften

  C4H11N; farblose, aminartig riechende Flüssigkeit.

• Gefahren für Mensch und Umwelt

  Leicht entzündlich. Die Dämpfe sind schwerer als Luft und bilden mit Luft ein explosionsfähiges Gemisch. Bei Kontakt mit
  Oxidationsmitteln heftige Reaktion oder Entzündung. Bei Kontakt mit Quecksilber kann explosionsartige Reaktion erfolgen (keine Quecksilberthermometer verwenden).
  
  Diethylamin wirkt als Dampf stark reizend auf die Schleimhäute der Augen und der Atmungsorgane sowie als Flüssigkeit ebenfalls stark reizend auf die Haut. Flüssigkeitskontakt mit dem Auge kann schwere Hornhautschäden bewirken. Sensibilisierung ist möglich und führt zu Lid- und Gesichtsödemen sowie zu Hautentzündungen.
  Schwach wassergefährdender Stoff (WGK 1).

• Schutzmaßnahmen und Verhaltensregeln

  Im Abzug arbeiten.
  Schutzhandschuhe nur als kurzzeitiger Spritzschutz.

• Verhalten im Gefahrfall

  Mit flüssigkeitsbindendem Material (Sand, Kieselgur) aufnehmen. Als Sondermüll entsorgen.
  Wassernebel, Kohlendioxid, Löschpulver, Schaum.

• Erste Hilfe

  Nach Hautkontakt: Mit Seife und reichlich Wasser abwaschen. Mit Polyethlenglycol 400 abtupfen.
  Nach Augenkontakt: Gründlich mit viel Wasser bei geöffnetem Augenlid mind. 10 Min. mit Wasser spülen. Augenarzt konsultieren.
  Nach Einatmen: Frischluft.
  Nach Verschlucken: Viel Wasser trinken lassen - möglichst mit Aktivkohlezusatz. Auf keinen Fall fette Öle oder Milch verabreichen.
  Nach Kleidungskontakt: Benetzte Kleidung sofort ausziehen.
  Ersthelfer: siehe gesonderten Anschlag

• Sachgerechte Entsorgung

  Als Sondermüll entsorgen.

• Beschreibung

  Diethylamine is a colourless, strongly alkaline, fish odour liquid, and highly inflammable. It has an ammonia-like odour and is completely soluble in water. On burning, diethylamine releases ammonia, carbon monoxide, carbon dioxide, and nitrogen oxides. Diethylamine is used in the production of pesticides. It is used in a mixture for the production of DEET which goes into the repellents that are found readily in supermarkets for general use.

• Chemische Eigenschaften

  Diethylamine is a clear, alkaline liquid with a strong ammonia-like odor. The odor threshold for diethylamine is 0.14 ppm, which gives good warning of its presence. The boiling point is 56° C, and the vapor pressure is 195 mm Hg at 20° C (CRC Handbook, 1980). Diethylamine is soluble in water, ethanol, diethyl ether, acetone, aliphatic and aromatic hydrocarbons, mineral oils, and stearic and oleic acids (NIOSH, 1979). The hydrochloride salt of diethylamine is a crystalline solid with a melting point of 226° C and a boiling point range of 320° to 330° C (Merck, 1996). The salt is soluble in water, ethanol, and chloroform but is practically insoluble in diethyl ether. Diethylamine (pkb=3.0) is more alkaline than ammonia (pkb=4.76) (Beard and Noe, 1981). The more alkaline the compound, the lower the pkb.

• Physikalische Eigenschaften

  Colorless liquid with a fishy, ammonia-like odor. Experimentally determined detection and recognition odor threshold concentrations were 60 μg/m3 (20 ppbv) and 180 μg/m3 (60 ppbv), respectively (Hellman and Small, 1974). Diethylamine is a very strong base in aqueous solution (pKb = 3.0). Its chemistry is governed by the unshared electron pair on the nitrogen, thus it tends to react with acids to form salts.

• Occurrence

  Diethylamine occurs in low concentrations in food and other biological materials. Concentrations (in p.p.m.) in fresh products include: spinach (15), apples (3), butterbeans (2.4), shelled peas (0.1), bean salad (1.5) and red cabbage (2.4) (HSDB 1989). Pickled vegetables contain 0-3.2 p.p.m. diethylamine while concentrations (in p.p.m.) in other materials include herring (0-5.2), barley (5.7), hops (3.1), boiled beef (2), tobacco leaf (0.1-35) and cigarette smoke concentrate (0-0.4). Interest in the occurrence of diethylamine in foods arises in part because of its possible formation of a carcinogenic N-nitroso derivative (Neurath et al 1977). Diethylamine has been reported in the exhaust from a gasoline engine (Hampton et al 1982).

• Verwenden

  Diethylamine is manufactured by heating ethyl chloride and alcoholic ammonia under pressure or by hydrogenation of aziridines in the presence of catalysts. DEA is used as a solvent, as a rubber accelerator, in the organic synthesis of resins, dyes, pesticides, and pharmaceuticals, in electroplating, and as a polymerization inhibitor. Other applications include uses as a corrosion inhibitor. It was reported noneffective as a skin depigmentator.

• Definition

  ChEBI: Diethylamine is a secondary aliphatic amine where both N-substituents are ethyl. It is a conjugate base of a diethylammonium.

• Vorbereitung Methode

  Diethylamine is produced using the three methods also used for the manufacture of ethylamine with very slight modification.
  Diethylamine Synthesis
  1. N,N-Diethyl-3-methylbenzamide + Ethylene Glycol + NaOH + Heat
  2. Ethylchloride + Ammonia (forms diethylamine HCL)
  3. Ethanol + Ammonia + Sulfuric Acid
  The most widely used method is the passing of ammonia and ethanol over a catalyst such as alumina or silica (Schweizer et al 1978). Diethylamine can be separated from the mixture by selective distillations and extractions.

• Allgemeine Beschreibung

  Diethylamine appears as a clear colorless liquid with an ammonia-like odor. Density 5.9 lb / gal. Flash point -15 °F. A respiratory irritant. Corrosive to the eyes and skin. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.

• Air & Water Reaktionen

  Highly flammable. Soluble in water. Sensitive to heat. May be sensitive to prolonged exposure to air.

• Reaktivität anzeigen

  It is incompatible with several chemical substances such as strong oxidisers, acids, cellulose nitrate, some metals, and dicyanofuroxan. N-nitrosamines, many of which are known to be potent carcinogens, may be formed when diethylamine comes in contact with nitrous acid, nitrates, or atmospheres with high nitrous oxide concentrations.

• Health Hazard

  Diethylamine can be harmful if it is inhaled, swallowed, or in contact with skin. Vapors can irritate the eyes and cause irritation of the respiratory tract, leading to coughing and chest pain. Liquid diethylamine can cause severe burns to the eyes and skin. Vision became misty and halos appeared several hours after workmen were exposed to the vapors of amines such as diethylamine (Grant 1986). The edema of the corneal epithelium, which is principally responsible for the disturbances in vision, clears after one or more days, depending on the severity of exposure. Photophobia and discomfort from roughness of the corneal surface also can occur after greater exposure to the amine.

• Flammability and Explosibility

  Highly flammable

• Chemische Reaktivität

  Reactivity with Water No reaction; Reactivity with Common Materials: No hazardous reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

• Industrielle Verwendung

  Diethylamine, like many of the other short chain aliphatic amines, has achieved widespread industrial use as an intermediate in the manufacture of a number of commercial products. Among these are included insecticides, pharmaceuticals, textile finishing agents, and corrosion inhibitors (Hawley 1981; Schweizer et al 1978). It is used as a polymerization inhibitor and/or catalyst in the polymer industry and in the manufacture of surfactants and rubber processing accelerators. This amine also is useful as a depilatory agent for animal skins, as a selective solvent for the removal of impurities from oils, fats, and waxes, and as a flotation agent in the petroleum industry (NIOSH/OSHA 1981; HSDB 1989).

• Toxikologie

  Exposure to low vapor concentrations are reported to transiently impair vision in humans (reduction of sensitivity to light): no-effect threshold 0.022 – 0.028 mL/m3 ( 0.08mg/m3 ). The odor threshold in air is ca. 0.02 – 0.3 mL/m3 ( 0.9 mg/m3 ). Transient physiological effects in rats after 90-d exposure to vapors were reported to already be visible at 0.37 – 4.19 mg/m3 with no effects at 0.05 mg/m3 , but with morphological, apparently reversible changes in the lung and cerebral neurons at the highest concentration. On the other hand, 50 mL/m3 (150 mg/m3 ) was the lowest concentration to show mild, but signifi- cant effects in the lung and liver of rabbits on prolonged inhalation. There were no visible signs of toxicity following exposure of rats to 25 mL/m3 (75 mg/m3 ) for 120 d, but a moderate, bronchiolar hyperplasia of lymphoid cells. It was assumed that diethylamine may exert a certain neurotoxic effect, which, however, was not confirmed by others.
  

• Sicherheitsprofil

  Moderately toxic by ingestion, inhalation, and skin contact. A skin and severe eye irritant. Exposure to strong vapor can cause severe cough and chest pains. Contact with liquid can damage eyes, possibly permanently; contact with skin causes necrosis and vesciculation. A very dangerous fire hazard when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam, CO2, dry chemical. Explodes on contact with dicyanofurazan. Violent reaction with sulfuric acid. Ignites on contact with cellulose nitrate of sufficiently high surface area. When heated to decomposition it emits toxic fumes of NOx. See also MINES.

• mögliche Exposition

  Tumorigen,Mutagen. Primary Irritant. Diethylamine (DEA) is used in themanufacture of the following chemicals: diethyldithiocarbamate and thiurams (rubber processing accelerators);diethylaminoethanol (medicinal intermediate); diethylaminopropylamine (epoxy curing agent); N,N-diethyl-m-toluamide and other pesticides; and 2-diethylaminoethylmethacrylate. Itis used in the manufacture of several drugs.

• Erste Hilfe

  If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.Medical observation is recommended for 24-48 h afterbreathing overexposure, as pulmonary edema may bedelayed. As first aid for pulmonary edema, a doctor orauthorized paramedic may consider administering a corticosteroid spray.

• Carcinogenicity

  No evidence of mutagenicity was seen in Ames bacterial assays.8 Diethylamine has an ammonia-like odor that is detectable at 0.13ppm.
  The 2003 ACGIH threshold limit valuetime- weighted average (TLV-TWA) for diethylamine is 5ppm (15mg/m3) with a short-term excursion limit of 15ppm (45mg/m3) and an A4-not classifiable as a human carcinogen designation; there is a notation for skin absorption.

• Environmental Fate

  Photolytic. Low et al. (1991) reported that the photooxidation of aqueous secondary amine solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium and nitrate ions.
  Chemical/Physical. Diethylamine reacted with NOx in the dark forming diethylnitrosamine. In an outdoor chamber, photooxidation by natural sunlight yielded the following products: diethylnitramine, diethylformamide, diethylacetamide, ethylacetamide, ozone, acetaldehyde, and peroxyacetyl nitrate (Pitts et al., 1978).
  Reacts with mineral acids forming water-soluble salts (Morrison and Boyd, 1971).

• Stoffwechsel

  Little information is available regarding the metabolism of diethylamine. The amine can be readily absorbed from the respiratory and gastrointestinal tract. It has been reported that following oral administration of diethylamine hydrochloride to humans, much of the amine was recovered in the urine (Beard and Noe 1978). This suggests that it is not readily metabolized and, therefore, may not be a substrate for monoamine oxidase. When administered intraperitoneally to rats, it was moderately inhibitory with respect to liver monoamine oxidase (Valiev 1974). Diethylamine may serve as a precursor for the formation of the reportedly carcinogenic N-nitrosoamines and, indeed, when a diethylamine containing liquid was examined for nitrosation reactions under simulated conditions of the human stomach, N-nitrosodiethylamine was formed (Ziebarth 1985).

• Lager

  Diethylamine should be protected from physical damage. It should be kept stored in a cool, dry, well-ventilated location, away from incompatible chemical substances and away from fi re hazard and smoking areas. The containers should be bonded and grounded for transfer to avoid static sparks. Storage and use areas should be no smoking areas.

• Versand/Shipping

  This compound requires a shipping label of“FLAMMABLE LIQUID.” It falls in Hazard Class 3 andPacking Group II.

• läuterung methode

  Dry diethylamine with LiAlH4 or KOH pellets. Reflux with, and distil it from, BaO or KOH. Convert it to the p-toluenesulfonamide and crystallise to constant melting point from dry pet ether (b 90-120o), then hydrolyse with HCl, excess NaOH is added, and the amine is passed through a column of activated alumina. Redistil the amine and dry it with activated alumina before use [Swift J Am Chem Soc 64 115 1942]. [Beilstein 4 III 313.] § A polystyrene diethylaminomethyl supported version is commercially available.

• Inkompatibilitäten

  Forms explosive mixture with air. Mayaccumulate static electrical charges, and may cause ignitionof its vapors. Violent reaction with strong oxidizers, strongacids, cellulose nitrate. Incompatible with organic anhydrides, isocyanates, vinyl acetate, acrylates, substitutedallyls, alkylene oxides, epichlorohydrin, ketones, aldehydes,alcohols, glycols, mercury, phenols, cresols, caprolactumsolution. Attacks aluminum, copper, lead, tin, zinc, andalloys.

• Vorsichtsmaßnahmen

  Occupational workers and users should be very careful during the use and chemical management of diethylamine. Workers should wear impervious protective clothing, including boots, gloves, a laboratory coat, apron or coveralls, as appropriate, to prevent skin contact. The chemical is very hazardous, corrosive, and harmful, and is a very flammable liquid and vapor. Exposures to vapor may cause fl ash fi re. It causes burns and adverse effects to the cardiovascular system. Workers should use chemical safety goggles and a full-face shield to avoid splashing of the chemical substance. An eye-wash fountain and quickdrench facilities in the work area should be maintained by the chemical management unit.

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