Diethylcarbamoylchlorid

Bezeichnung:Diethylcarbamoylchlorid

CAS-Nr88-10-8

Englisch Name:Diethylcarbamyl chloride

CBNumberCB8275909

SummenformelC5H10ClNO

Molgewicht135.59

MOL-Datei88-10-8.mol

Synonyma

Diethylcarbamoylchlorid

Diethylcarbamoylchlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	−32 °C(lit.)
Siedepunkt	117-123 °C133 mm Hg(lit.)
Dichte	1.07 g/mL at 25 °C(lit.)
Brechungsindex	n20/D 1.451(lit.)
Flammpunkt	167 °F
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	Chloroform (Soluble), Methanol (Slightly)
pka	-1.85±0.70(Predicted)
Aggregatzustand	Liquid
Farbe	Clear
Wichte	1.070
Wasserlöslichkeit	HYDROLYSIS
Sensitive	Moisture Sensitive
BRN	506687
Stabilität	Moisture Sensitive
InChIKey	OFCCYDUUBNUJIB-UHFFFAOYSA-N
CAS Datenbank	88-10-8(CAS DataBase Reference)
NIST chemische Informationen	Carbamic chloride, diethyl-(88-10-8)
EPA chemische Informationen	Diethylcarbamoyl chloride (88-10-8)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/22-36/37/38-40
S-Sätze:	26-36/37
RIDADR	UN 3265 8/PG 3
WGK Germany	1
RTECS-Nr.	FD4025000
TSCA	Yes
HazardClass	8
PackingGroup	II
HS Code	29241990
Giftige Stoffe Daten	88-10-8(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Diethylcarbamyl chloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/22:Gesundheitsschädlich beim Einatmen und Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Diethylcarbamoyl chloride is a colorless liquid.Molecular weight=135.61; Boiling point=186-190℃;Melting point=244; Flash point=163-172℃. HazardIdentification (based on NFPA-704 M Rating System):Health 2, Flammability 1, Reactivity 2. Soluble in water(reactive).
Chemische Eigenschaften
clear yellow to brownish liquid
Verwenden
It is used in the production of pharma ingredients. It is a reagent in the synthesis of S-Methyl-N,N-diethylthiocarbamate Sulfoxide, which is an oxygenated metabolite of Disulfiram (Antabuse) that is capable of in vitro inactivation of liver mitochondrial aldehyde dehydrogenase.
Toxikologie
The median lethal dose (LD50) upon oral administration to rats is about 200 mg/kg. The compound is irritating to skin and eyes. The inhalation of an atmosphere saturated with its vapors at 20℃ is lethal to rats after 3 h. Diethylcarbamoyl chloride has proved to be mutagenic on E. coli strains in mutagenicity tests. It is weakly mutagenic in high doses in the Ames test. In view of these results and on account of the structural similarity to dimethylcarbamoyl chloride, a carcinogenic potential cannot be ruled out. The MAK commission has listed this substance in group III B.
Sicherheitsprofil
Suspected carcinogen with experimental carcinogenic data. Moderately toxic by intraperitoneal route. Mutation data reported. Reacts with water or steam to produce toxic and corrosive fumes. When heated to decomposition it emits highly toxic fumes of Cl and NOx. See also CARBATMATES and CHLORIDES.
mögliche Exposition
Diethylcarbamazine citrate, a carbamate anthelmintic (working agent), used in the synthesis ofpharmaceuticals.
Erste Hilfe
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. If victim is conscious, administer water ormilk. Do not induce vomiting.
Lager
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area away from oxidizers and reducing agents.Where possible, automatically pump liquid from drums orother storage containers to process containers. A regulated,marked area should be established where this chemical ishandled, used, or stored in compliance with OSHAStandard 1910.1045.
Versand/Shipping
Toxic liquids, water-reactive, n.o.s. require a labelof “POISONOUS/TOXIC MATERIALS, DANGEROUSWHEN WET.” They fall in Hazard Class 6.1.
Inkompatibilitäten
Will react with water or steam to producetoxic and corrosive fumes.
Long Term Exposure
A study has shown DECC to bemutagenic in two E. coli strains (WP2 and WP2S fromWitkin). However, DECC was not as mutagenic as its closeanalog, dimethylcarbamoyl chloride (DMCC). A suspectedcarcinogen.
Personal Protective Methods
Wear protective gloves andclothing to prevent any reasonable probability of skin contact. Safety equipment suppliers/manufacturers can providerecommendations on the most protective glove/clothingmaterial for your operation. All protective clothing (suits,gloves, footwear, headgear) should be clean, available eachday, and put on before work. Contact lenses should not beworn when working with this chemical. Wear splash-proofchemical goggles and face shield unless full face-piecerespiratory protection is worn. Employees should washimmediately with soap when skin is wet or contaminated.Provide emergency showers and eyewash.
Fire Extinguishing
This chemical is a combustible liquid.Poisonous gases, including nitrogen oxides and chlorides,are produced in fire. Use dry chemical, carbon dioxideextinguishers. Reacts with water, forming corrosive andtoxic fumes. Vapors are heavier than air and will collect inlow areas. Vapors in confined areas may explode whenexposed to fire. Containers may explode in fire. Storagecontainers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users ofpotentially contaminated waters. Notify local health and fireofficials and pollution control agencies. From a secure,explosion-proof location, use water spray to cool exposedcontainers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows anysigns of deforming), withdraw immediately to a secure position. If employees are expected to fight fires, they must betrained and equipped in OSHA 1910.156. The only respirators recommended for firefighting are self-contained breathing apparatuses that have full face-pieces and are operatedin a pressure-demand or other positive-pressure mode.

Diethylcarbamyl chloride Upstream-Materialien And Downstream Produkte

Diethylcarbamoylchlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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