1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid

Bezeichnung:1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid

CAS-Nr70476-82-3

Englisch Name:Mitoxantrone hydrochloride

CBNumberCB4246424

SummenformelC22H30Cl2N4O6

Molgewicht517.4028

MOL-Datei70476-82-3.mol

Synonyma

1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid

1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	203-205 C
storage temp.	2-8°C
Löslichkeit	Sparingly soluble in water, slightly soluble in methanol, practically insoluble in acetone.
Aggregatzustand	Solid
Farbe	Dark Blue to Black
Wasserlöslichkeit	Soluble to 5 mM in water and to 75 mM in DMSO
InChI	InChI=1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
InChIKey	ZAHQPTJLOCWVPG-UHFFFAOYSA-N
SMILES	C1(O)=C2C(C(=O)C3=C(C2=O)C(NCCNCCO)=CC=C3NCCNCCO)=C(O)C=C1.[H]Cl.[H]Cl
CAS Datenbank	70476-82-3(CAS DataBase Reference)
EPA chemische Informationen	Mitoxantrone hydrochloride (70476-82-3)

Sicherheit

Kennzeichnung gefährlicher	T,T+
R-Sätze:	46-61-26/27/28
S-Sätze:	53-36/37/39-45-22
RIDADR	3249
WGK Germany	3
RTECS-Nr.	CB5748500
HazardClass	6.1(b)
PackingGroup	III
HS Code	29146100
Giftige Stoffe Daten	70476-82-3(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Mitoxantrone hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R46:Kann vererbbare Schäden verursachen.
R61:Kann das Kind im Mutterleib schädigen.
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S22:Staub nicht einatmen.
Beschreibung
Mitoxantrone hydrochloride is the first of the synthetic anthracenediones related to doxorubicin to reach the marketplace. Mitoxantrone is useful in the treatment of advanced localized and metastatic mammary carcinomas. It is reported to be less cardiotoxic than doxorubicin.
Beschreibung
Mitoxantrone is an anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC₅₀ = 5.3 μM), thus inhibiting cell proliferation. It also inhibits HIV-1 integrase (IC₅₀ = 3.8 μM). Mitoxantrone is exported from cells in an ATP- and glutathione-dependent manner by multidrug resistance protein-1. Formulations containing mitoxantrone have been used in the treatment of cancer and multiple sclerosis.
Chemische Eigenschaften
Dark blue, electrostatic, hygroscopic powder.
Originator
Lederle (USA)
Verwenden
Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.
Verwenden
Mitoxanthrone hydrochloride USP (Novantrone) is used to traet acute nonlymphocytic leukemia, including myelogenous promyelocytic, monocytic, and erythroid acute leukemias.
Verwenden
analgesic, antipyretic
Definition
ChEBI: Mitoxantrone dihydrochloride is a hydrochloride. It has a role as an antineoplastic agent. It contains a mitoxantrone.
Manufacturing Process
A suspension of 12.5 g of 2-(2-aminoethylamino)ethanol in 40 ml of N,N,N',N'-tetramethylethylenediamine is stirred and de-aerated by bubbling nitrogen in for 15 min. A 10.97 g of leuco-1,4,5,8-tetrahydroxyanthraquinone is gradually added with stirring. The suspension is heated and stirred under nitrogen at 50-52°C for 5 hours. The mixture is allowed to stand and cool under nitrogen for 12 hours. The solid is collected by decantation, macerated in ethanol, collected and washed with ethanol giving 15.06 g of the desired product leuco-1,4-bis[2-(2-hydroxyethylamino)ethylamino]-5,8- dihydroxyanthraquinone as a green-gray solid, melting point 129-131°C.
Chloranil oxidation. To 17.86 g of a suspension of the leuco-1,4-bis[2-(2- hydroxyethylamino)ethylamino]-5,8-dihydroxyanthraquinone (0.03 mole) in 2- methoxyethanol was added gradually with stirring 15 ml of 8 N ethanolic hydrogen chloride. The system was chilled with an ice bath and stirred as 7.50 g (0.0305 mole) of chloranil powder was gradually added. The mixture was stirred overnight at room temperature and diluted with 600 ml of ether. The solid was collected and washed with tetrahydrofuran. Yield of 1,4-bis[2-(2- hydroxyethylamino)ethylamino]-5,8-dihydroxyanthraquinone dihydrochloride 21.34 g, melting point 203-205°C (without recrystallisation).
Trademarks
Novantrone (Serono).
Therapeutic Function
Antineoplastic
Allgemeine Beschreibung
Mitoxantrone is supplied as a blue aqueous solution in 10-and 20-mg vials for IV administration in the treatment of acute lymphoid leukemia, acute myeloid leukemia, breastcancer, prostate cancer, non-Hodgkin’s lymphoma, andmultiple sclerosis. The mechanisms of resistance are thesame as those seen for the anthracyclines. The distributionhalf-life is 1.1 to 3.1 hours, and the drug has a large volumeof distribution (11 L/kg). The elimination half-life rangedfrom 23 to 215 hours, and elimination was primarily via thebile. Metabolism of the agent involves oxidation of the sidechainalcohols to give the monocarboxylic and dicarboxylicacids.Other toxicities are those seen for the anthracyclinesand include myelosuppression, nausea, vomiting, mucositis,diarrhea, and alopecia. The intense color of the parent drugand metabolites may turn the urine blue.
Biologische Aktivität
Mitoxantrone hydrochloride (Mitoxantrone dihydrochloride) is a type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC50 = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC50= 3.15 μM). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2.
Biochem/physiol Actions
Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells. It used clinically as a chemotherapeutic agent against leukemias and solid tumors and as an immune system modulator in multiple sclerosis.
Clinical Use
Mitoxantrone is used in combination with other agents during the initial treatment of acute nonlymphocytic leukemia and hormone-refractory prostate cancer. Recent studies have shown that mitoxantrone also decreases the rate of relapse and disease progression in patients with multiple sclerosis. Although too toxic for use in patients with primary progressive disease, it is available for the treatment of chronic progressive, progressive relapsing, or deteriorating relapsing-remitting multiple sclerosis.
Nebenwirkungen
Common side effects of Mitoxantrone hydrochloride include: Swelling of the body; Infection, possibly in the blood, especially when white blood cell count is low; Sores in mouth and throat which may cause difficulty swallowing; Diarrhea, nausea, vomiting; Headache; Pain in belly, back, joints, or muscles; Abnormal or absence of menstrual period; Tiredness, fever; Hair loss; Hives, rash. Less common side effects include: Damage to the heart or heart failure which may cause shortness of breath, tiredness and swelling; Bruising, bleeding; Anemia which may cause tiredness, or may require transfusion; Liver damage which may cause yellowing of eyes and skin, swelling; Internal bleeding which may cause belly pain, black tarry stool, blood in vomit; Constipation, loss of appetite; Abnormal sexual function; Worry, depression; Swelling and redness at the site of the injection; Changes in weight; Swelling and redness of the whites of the eye; Increased sweating; Loss of nails, darkening of the skin and nails; Bluish/greenish discoloration of the urine, skin, eyes and saliva. A rare side effect is bone marrow cancer (leukaemia) caused by chemotherapy.
Stoffwechsel
Mitoxantrone excretion primarily is biliary. Both the unchanged drug and inactive metabolites resulting from N-dealkylation, deamination, and oxidation of the resultant aldehyde to the carboxylic acid are observed. Both arms of the structure can be metabolized, leading to mono- or dicarboxylic acid metabolites, which are excreted as the glucuronide conjugate. The conjugated metabolites are an intense, dark blue in color and will result in blue-green urine.
Lager
Desiccate at RT

Mitoxantrone hydrochloride Upstream-Materialien And Downstream Produkte

1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthrachinondihydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

70476-82-3, Mitoxantrone hydrochloride Verwandte Suche:

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