Pyraclofos

Bezeichnung:Pyraclofos

CAS-Nr77458-01-6

Englisch Name:Pyraclofos

CBNumberCB3681581

SummenformelC14H18ClN2O3PS

Molgewicht360.8

MOL-Datei77458-01-6.mol

Pyraclofos physikalisch-chemischer Eigenschaften

Schmelzpunkt	25°C
Siedepunkt	164approximate 164℃(0.013hPa)
Dichte	1.27
Dampfdruck	1.6×10^-6 Pa (20 °C)
storage temp.	0-6°C
Wasserlöslichkeit	33
Aggregatzustand	liquid
Wichte	1.271 (28℃)
CAS Datenbank	77458-01-6(CAS DataBase Reference)
EPA chemische Informationen	Phosphorothioic acid, O-[1-(4-chlorophenyl)-1H-pyrazol- 4-yl] O-ethyl S-propyl ester(77458-01-6)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	22
RIDADR	3018
RTECS-Nr.	TE8346000
HazardClass	6.1(b)
PackingGroup	III
HS Code	29331990

Gefahreninformationscode (GHS)

Pyraclofos Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
Verwenden
Pyraclofos is used to control Lepidoptera, Coleoptera, mites and nematodes in fruit, vegetables, ornamentals and forestry. It has also been used in a human health application to control filarial worms.
Definition
ChEBI: Pyraclofos is an organic thiophosphate, an organothiophosphate insecticide, an organochlorine insecticide, a member of pyrazoles, a member of monochlorobenzenes and an organosulfur compound. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor and an agrochemical.
Stoffwechselwegen
Pyraclofos is apparently subjected in insects to a metabolic activation to yield a more active acetylcholinesterase inhibitor which is possibly a thiooxidized metabolite. The compound is very rapidly degraded in mammals to inactive metabolites via P-O-aryl, P-O-alkyl and P-S-alkyl cleavage which explains its favourable selective toxicity. In both mammals and plants the principal degradative route is via P-O-aryl cleavage to give 1-(4-chlorophenyl)-4-hydroxypyrazolwe hich is rapidly conjugated.
Stoffwechsel
Pyraclofos is metabolized to an active AChE inhibitor, probably by the oxidation of the sulfur atom in the phosphorothiolate linkage. The half-life in soil is 3–38 d, depending on soil type.
Toxicity evaluation
The acute oral LD₅₀ for rats is 237 mg/kg. The inhalation LC50 for rats is 1.69 mg/L air. NOEL (2 yr) for rats is 0.10–0.12 mg/kg diet (0.005–0.006 mg/kg/d). Pyraclofos administered to rats is rapidly degraded, and more than 90% of the dose is excreted principally in the urine within 24 h. The degradation routes are cleavages of the P?S, P?O-alkyl, and P?O-aryl bonds in both animals and plants.
Degradation
The DT₅₀ for hydrolysis in water at pH 7 (25 °C) was 29 days (PM).

Pyraclofos Upstream-Materialien And Downstream Produkte

Pyraclofos Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

77458-01-6, Pyraclofos Verwandte Suche:

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