3-Methyl-1-phenyl-5-pyrazolon Produkt Beschreibung

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Struktur
89-25-8
  • CAS-Nr.89-25-8
  • Bezeichnung:3-Methyl-1-phenyl-5-pyrazolon
  • Englisch Name:5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
  • Synonyma:3-Methyl-1-phenyl-5-pyrazolon
    PMP;Radicu;NSC-12;Radicut;MCI-186;NSC-2629;Adaravone;EDARAVONE;NSC-26139;developerz
  • CBNumber:CB1287462
  • Summenformel:C10H10N2O
  • Molgewicht:174.2
  • MOL-Datei:89-25-8.mol
3-Methyl-1-phenyl-5-pyrazolon physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :126-128 °C(lit.)
  • Siedepunkt: :287 °C265 mm Hg(lit.)
  • Dichte :1,12 g/cm3
  • Brechungsindex :1.6300 (estimate)
  • Flammpunkt: :191°C/17mm
  • storage temp.  :Store at RT
  • Löslichkeit :3.30g/l
  • pka :2.73±0.50(Predicted)
  • Aggregatzustand :Crystalline Powder
  • Farbe :Yellow to beige
  • PH :4.0-4.4 (H2O, 20℃)(saturated aqueous solution)
  • Wasserlöslichkeit :3 g/L (20 ºC)
  • Merck  :14,6713
  • BRN  :609575
  • InChIKey :QELUYTUMUWHWMC-UHFFFAOYSA-N
  • CAS Datenbank :89-25-8(CAS DataBase Reference)
  • NIST chemische Informationen :3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-(89-25-8)
  • EPA chemische Informationen :1-Phenyl-3-methyl-5-pyrazolone (89-25-8)
Sicherheit
  • Kennzeichnung gefährlicher :Xi
  • R-Sätze: :36/37/38
  • S-Sätze: :26-36
  • WGK Germany  :1
  • RTECS-Nr. :UQ9625000
  • TSCA  :Yes
  • HS Code  :29331990
  • Giftige Stoffe Daten :89-25-8(Hazardous Substances Data)
  • Toxizität :LD50 orl-rat: 3500 mg/kg LONZA# 08FEB79

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  • Beschreibung Edaravone was marketed in Japan for improving neurologic recovery following acute brain infarction. Currently, several agents classified as neuroprotectants and acting by diverse mechanisms (inhibition of glutamate release, blockade of calcium channels, lazaroids) have been marketed for treating the outcomes of brain damage due to trauma, ischemia or cardiac arrest. Edavarone is the first antioxidant with free radical scavenging activity to be introduced for this pathology. This previously described molecule (in particular as norantipyrine, one of three metabolites of antipyrine in mammals) can be simply prepared by direct cyclization of phenylhydrazine with alkylacetoacetate. Edarevone is a lipophilic agent, readily accessible to brain tissue, that is capable of reducing edema in the brain following ischemia by blocking the arachidonic acid cascade triggering peroxidative neurodegeneration. Interestingly, this agent has been shown to quench active oxygen species in endothelial cell homogenate, as well as inhibiting in vitro lipid peroxidative disintegration of membranes, so making this compound effective during reperfusion following ischemic injury. As an additional indication, phase III trials started with edaravone for increasing the chance of recovery after subarachnoid hemorrhage.
  • Chemische Eigenschaften Off white to light yellow powder
  • Originator Mitsubishi Pharma (Japan)
  • Verwenden Edaravone inhibits the disease activity in rheumatoid arthritis.
  • Verwenden antioxidant, lipoxygenase inhibitor
  • Definition ChEBI: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.
  • Trademarks Radicut
  • Hazard Toxic by ingestion.
  • Biologische Aktivität A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity.
  • Sicherheitsprofil Moderately toxic by ingestion andintraperitoneal routes. An eye irritant. When heated todecomposition it emits toxic fumes of NOx.
  • läuterung methode Crystallise the pyrazolone from hot H2O, EtOH or EtOH/water (1:1). It complexes with metals. [Veibel et al. Acta Chim Scand 6 1066 1952, Beilstein 24 II 9, 24 III/IV 71.]
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-Methyl-1-phenyl-5-pyrazolon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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89-25-8, 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Verwandte Suche:
  • TIMTEC-BB SBB003801
  • PMP
  • MONOPYRAZOLONE
  • 2,4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-on
  • 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
  • 3H-Pyrazol-3-one,2,4-dihydro-5-methyl-
  • 3-methyl-1-phenyl-2-pyrazolin-5-on
  • 3-methyl-1-phenyl-5-pyrazolon
  • 3-Methyl-1-phenylpyrazol-5-one
  • 3-Methyl-1-phenylpyrazolin-5-one
  • 5-Pyrazolone, 3-methyl-1-phenyl-
  • Developer Z
  • 3-Methyl-1-pehnyl-2-pyrazolin-5-one
  • 1-phenyl-3-methyl-5-pyrazolone(PMP)
  • Adaravone
  • 3-Methyl-1-phenyl-2-pyrazolin-5-one, 98+%
  • 1-Phenyl-3-methyl-1H-4,5-dihydropyrazol-5-one
  • Radicu
  • 3-Methyl-1-phenyl-5-pyrazolido
  • 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
  • N-demethylantipyrine
  • PHENYLMETHYLPYRAZOLON
  • 3-methyl-1-pheny-1-1H-pyrazol-5(4H)-one
  • 3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE [NORANTIPYRINE]
  • Radicut
  • Methyl-1-phenyl-2-pyrazolin-5-one, 3-
  • 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one
  • 1-Phenyl-3-methyl-2-prazolin-5-one
  • 3-Methyl-1-phenylpyrazolin-5(4H)-one
  • 5-Methyl-2-phenyl-1H-pyrazol-3-one
  • -1,2-dihydropyrazoL
  • MCI-186
  • EDARAVONE
  • C.I. Developer 1
  • AURORA KA-3365
  • 2,4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-one
  • 1-PHENYL-3-METHYL-5-OXO-2-PYRAZOLINE
  • 1-PHENYL-3-METHYL-5-PYRAZALONE
  • 5-METHYL-2-PHENYL-2,4-DIHYDRO-3H-PYRAZOL-3-ONE
  • 5-METHYL-2-PHENYL-2,4-DIHYDRO-PYRAZOL-3-ONE
  • 3-METHYL-1-PHENYL-5-PYRAZOLONE
  • 3-METHYL-1-PHENYL-5-PYROZOLENE
  • 3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE
  • 3-METHYL-1-PHENYL-2-PYRAZOLINE-5-ONE
  • AKOS B029819
  • developerz
  • Methylphenylpyrazolone
  • NCI-C03952
  • norantipyrine
  • Norphenazone
  • NSC-12
  • NSC-26139
  • NSC-2629
  • phenylmethylpyrazolone
  • 1-Fenyl-3-methyl-2-pyrazolin-5-on
  • 1-Phenyl-3-methyl-5-pyrazolon
  • 1-Phenyl-3-methylpyrazolone
  • 1-Phenyl-3-methylpyrazolone-5