Methyl-7-chlor-6,7,8-tridesoxy-6-(((1-methyl-4-propyl-2-pyrrolidi-nyl)carbonyl)amino)-1-thio-L-threo-alpha-D-galacto-octopyrano-sid-2-(dihydrogenphosphat),(2S-trans)-

Bezeichnung:Methyl-7-chlor-6,7,8-tridesoxy-6-(((1-methyl-4-propyl-2-pyrrolidi-nyl)carbonyl)amino)-1-thio-L-threo-alpha-D-galacto-octopyrano-sid-2-(dihydrogenphosphat),(2S-trans)-

CAS-Nr24729-96-2

Englisch Name:Clindamycin phosphate

CBNumberCB8175076

SummenformelC18H34ClN2O8PS

Molgewicht504.96

MOL-Datei24729-96-2.mol

Synonyma

Methyl-(2S-trans)-7-chlor-6,7,8-tridesoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-L-threo-α-D-galakto-octopyranosid, 2-(Dihydrogenphosphat)

Methyl-7-chlor-6,7,8-tridesoxy-6-(((1-methyl-4-propyl-2-pyrrolidi-nyl)carbonyl)amino)-1-thio-L-threo-alpha-D-galacto-octopyrano-sid-2-(dihydrogenphosphat),(2S-trans)-

Methyl-7-chlor-6,7,8-tridesoxy-6-(((1-methyl-4-propyl-2-pyrrolidi-nyl)carbonyl)amino)-1-thio-L-threo-alpha-D-galacto-octopyrano-sid-2-(dihydrogenphosphat),(2S-trans)- physikalisch-chemischer Eigenschaften

Schmelzpunkt	114 °C
Siedepunkt	159°C
Dichte	1.41±0.1 g/cm3(Predicted)
Brechungsindex	122 ° (C=1, H2O)
storage temp.	Sealed in dry,2-8°C
Löslichkeit	DMSO: soluble224mg/mL at 25°C
Aggregatzustand	solid
pka	pKa 0.964±0.06 (H2O t=21) (Uncertain);6.06 ±0.06 (I=0.008)(H2O t=21) (Uncertain)
Farbe	White
Wasserlöslichkeit	Freely soluble in water
Merck	14,2356
Stabilität	Stable, but store cool. Incompatible with strong oxidizing agents, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, B group sodium vitamins.
InChIKey	UFUVLHLTWXBHGZ-YFBDLMQENA-N
SMILES	[C@]([H])([C@]1([H])[C@@H]([C@H](O)[C@@H](OP(O)(O)=O)[C@@H](SC)O1)O)([C@@H](Cl)C)NC([C@H]1N(C[C@H](CCC)C1)C)=O \|&1:0,2,4,5,7,13,18,23,26,r\|

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/37/38
S-Sätze:	36-26
WGK Germany	3
RTECS-Nr.	GF2625000
HS Code	29419000

Gefahreninformationscode (GHS)

Clindamycin phosphate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
solid or colorless solution with characteristic alcohol odor.
Verwenden
Clindamycin 2-phosphate is a a salt of clincamycin, a semi-synthetic lincosamide. The salt is prepared by selective phosphorylation of the 2-hydroxy moiety of the sugar of clindamycin. The introduction of the phosphate affords improved solubility for injectable formulations. Like other members of the lincosamide family, clindamycin 2-phosphate is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Clindamycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis.
synthetische
Preparation of Clindamycin Phosphate: a solution of 808 mg of the phosphorylated ester in 6 ml of pyridine and 16 ml of acetic acid is stirred at ambient temperature while s5 mg of zinc is rapidly added. The mixture is filtered after one hour and evapo rated to a residue which is heated with stirring at 50°C. for 2 hours with a solvent mixture of 2 ml of acetic acid, and 4 ml of 0.5N sulfuric acid. The mixture is cooled and filtered followed by evaporation of the filtrate in vacuo to a residue, which is chromatographed on a suitable ion-exchange resin, in the acid form, and eluted with 2% ammonium hydroxide. The desired product is obtained as ammonium salt by evaporation of the product fractions. (dec. 212°C)
Allgemeine Beschreibung
Clindamycin phosphate (Cleocin Phosphate) is the 2-phosphateester of clindamycin. It exists as a zwitterionic structurethat is very soluble in water. It is intended for parenteral(intravenous or intramuscular) administration for the treatmentof serious infections and instances when oral administrationis not feasible. Solutions of clindamycin phosphateare stable at room temperature for 16 days and for up to 32days when refrigerated.
Kontakt-Allergie
This lincosanide antibiotic is used in topical form for acne, or systemically has been responsible for exanthematous rashes and acute generalized exanthematous pustulosis.
Pharmakologie
Clindamycin phosphate is available in 1% concentration in a hydroalcoholic vehicle (30 or 60 mL) as a gel or lotion. Although the drug has not been detected in the blood after topical use, its detection in the urine suggests that 4% to 5% of topically applied clindamycin is absorbed.
Structure and conformation
Semisynthetic derivative of lincomycin.

Clindamycin phosphate Upstream-Materialien And Downstream Produkte

Methyl-7-chlor-6,7,8-tridesoxy-6-(((1-methyl-4-propyl-2-pyrrolidi-nyl)carbonyl)amino)-1-thio-L-threo-alpha-D-galacto-octopyrano-sid-2-(dihydrogenphosphat),(2S-trans)- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

24729-96-2, Clindamycin phosphate Verwandte Suche:

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