Lineomycin Hydrochloride

Bezeichnung:Lineomycin Hydrochloride

CAS-Nr859-18-7

Englisch Name:Lincomycin hydrochloride

CBNumberCB8141837

SummenformelC18H35ClN2O6S

Molgewicht443

MOL-Datei859-18-7.mol

Synonyma

Methyl-(2S-trans)-6,8-didesoxy-6-[[(1-methyl-4-propylpyrrolidin-2-yl)carbonyl]amino]-1-thio-D-erythro-α-D-galakto-octopyranosidmonohydrochlorid

Lineomycin Hydrochloride

Lineomycin Hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	156-158C
storage temp.	2-8°C
Löslichkeit	H₂O: 50 mg/mL, clear, colorless
Aggregatzustand	solid
Farbe	white to white with yellow cast
Wasserlöslichkeit	Soluble in water.
BRN	4171650
Stabilität	Hygroscopic
InChIKey	POUMFISTNHIPTI-BOMBIWCESA-N
SMILES	[C@]([H])([C@]1([H])[C@@H]([C@H](O)[C@@H](O)[C@@H](SC)O1)O)([C@H](O)C)NC([C@H]1N(C[C@H](CCC)C1)C)=O.Cl \|&1:0,2,4,5,7,9,14,19,22,r\|
EPA chemische Informationen	D-erythro-.alpha.-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride (1:1) (859-18-7)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-20/21/22
S-Sätze:	26-36
WGK Germany	2
RTECS-Nr.	RH6315000
F	10
HS Code	29419000

Gefahreninformationscode (GHS)

Lincomycin hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Crystalline
Originator
Lincocin,Upjohn,UK,1964
Verwenden
Antibacterial;Ribosomal protein synthesis inhibitor
Verwenden
An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.
Verwenden
Lincomycin hydrochloride is a salt of lincomycin formed at the basic N-methylproline. The hydrochloride salt is the preferred formulation for pharmaceutical use. Lincomycin hydrochloride is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.
Manufacturing Process
As described in US Patent 3,086,912, the process comprises cultivating Streptomyces lincolnensis var. lincolnensis in an aqueous nutrient medium containing a source of assimilable carbohydrate and assimilable nitrogen under aerobic conditions until substantial activity is imparted to the medium by production of lincolnensin and isolating the lincolnensin so produced.
Trademarks
Lincocin (Pharmacia & Upjohn).
Therapeutic Function
Antibacterial
Allgemeine Beschreibung
Chemical structure: macrolide
Biochem/physiol Actions
Mode of action: Lincomycin inhibits bacterial protein synthesis by forming cross-links within the peptidyl transferase loop region of the 23S rRNA.? Antimicrobial spectrum: Lincomycin hydrochloride is effective against gram-positive bacteria.
Clinical Use
Lincomycin is used for the treatment of infections causedby Gram-positive organisms, notably staphylococci, β-hemolyticstreptococci, and pneumococci. It is absorbed moderatelywell orally and distributed widely in the tissues.Effective concentrations are achieved in bone for the treatmentof staphylococcal osteomyelitis but not in the cerebrospinalfluid for the treatment of meningitis. At one time,lincomycin was considered a nontoxic compound, with alow incidence of allergy (rash) and occasional GI complaints(nausea, vomiting, and diarrhea) as the only adverseeffects. Recent reports of severe diarrhea and the developmentof pseudomembranous colitis in patients treated withlincomycin (or clindamycin), however, have necessitatedreappraisal of the role of these antibiotics in therapy. In anyevent, clindamycin is superior to lincomycin for thetreatment of most infections for which these antibiotics areindicated.
Lincomycin hydrochloride occurs as the monohydrate, awhite, crystalline solid that is stable in the dry state. It isreadily soluble in water and alcohol, and its aqueous solutionsare stable at room temperature. It is degraded slowlyin acid solutions but is absorbed well from the GI tract.Lincomycin diffuses well into peritoneal and pleural fluidsand into bone. It is excreted in the urine and the bile. It isavailable in capsule form for oral administration and inampules and vials for parenteral administration.

Lincomycin hydrochloride Upstream-Materialien And Downstream Produkte

Lineomycin Hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

859-18-7, Lincomycin hydrochloride Verwandte Suche:

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