Norgestrel

Bezeichnung:Norgestrel

CAS-Nr6533-00-2

Englisch Name:Norgestrel

CBNumberCB2752440

SummenformelC21H28O2

Molgewicht312.45

MOL-Datei6533-00-2.mol

Synonyma

Norgestrel

Norgestrel physikalisch-chemischer Eigenschaften

Schmelzpunkt	239-241 °C(lit.)
Siedepunkt	392.36°C (rough estimate)
Dichte	1.0697 (rough estimate)
Brechungsindex	1.4900 (estimate)
storage temp.	2-8°C
Löslichkeit	Chloroform (Slightly, Sonicated), Dichloromethane (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	13.09±0.40(Predicted)
Farbe	Crystals from diethyl ether-hexane
InChIKey	WWYNJERNGUHSAO-XUDSTZEESA-N
CAS Datenbank	6533-00-2(CAS DataBase Reference)
EPA chemische Informationen	Norgestrel (6533-00-2)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-40
S-Sätze:	22-36
WGK Germany	3
RTECS-Nr.	JF8259000
HS Code	2937230000
Giftige Stoffe Daten	6533-00-2(Hazardous Substances Data)
Toxizität	LD50 oral in rat: 5010mg/kg

Gefahreninformationscode (GHS)

Norgestrel Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Norgestrel is a synthetic progestin and a racemic mixture of dextronorgestrel and levonorgestrel , of which levonorgestrel is the biologically active component. In vivo, norgestrel administered via intrauterine device (IUD) prevents pregnancy in rats. Formulations containing nogestrel have been used as contraceptives.
Chemische Eigenschaften
White Solid
Verwenden
It is an excellent progestational and ovulation inhibiting steroid. The bioactive enantiomer is levorotatory. Progestogen; oral contraceptive.
Verwenden
A metabolite of Norgestrel.
Verwenden
analgesic, antipyretic
Verwenden
Progestogen; oral contraceptive. The bioactive enantiomer is levorotatory
Verwenden
An intermediate to the glucuronide metabolite of Levonorgestrel.
Verwenden
Protected D-(-)-Norgestrel
Verwenden
A glucuronide metabolite of Levonorgestrel.
Definition
ChEBI: Levonorgestrel is a 17beta-hydroxy steroid, a 3-oxo-Delta(4) steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin, a synthetic oral contraceptive and a female contraceptive drug. It is functionally related to a norgestrel. It is an enantiomer of a dexonorgestrel.
Trademarks
Ovrette (Wyeth).
Allgemeine Beschreibung
Norgestrel, (17α)-(±)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one, and levonorgestrel, (17α)-(-)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one,have a C13 ethyl group instead of the C13 methyl but haveprogestational properties similar to those of norethindrone,with decreased androgenic effects. The ethyl group apparentlyprovides unfavorable steric interactions with the ARthat reduce the affinity compared with that with the PRs.Norgestrel is a racemic mixture, while levonorgestrel is thesingle active levorotatory enantiomer. Norgestrel is usedonly in oral contraceptives. Levonorgestrel is used in bothoral combination birth control products and polymeric implantsthat provide contraception for up to 5 years.
Sicherheitsprofil
Human reproductive effects byingestion and implant: menstrual cycle changes ordisorders and female fertility index changes. Anexperimental teratogen. Experimental reproductiveeffects. Questionable carcinogen with experimentalneoplastigenic data. An o

Norgestrel Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

6533-00-2, Norgestrel Verwandte Suche:

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