Ethisteron

Bezeichnung:Ethisteron

CAS-Nr434-03-7

Englisch Name:Ethisterone

CBNumberCB1207877

SummenformelC21H28O2

Molgewicht312.45

MOL-Datei434-03-7.mol

Synonyma

Ethisteron

Ethisteron physikalisch-chemischer Eigenschaften

Schmelzpunkt	263-269 °C (lit.)
alpha	D23 +23.8° (dioxane); D25 -32.0° (pyridine)
Siedepunkt	392.36°C (rough estimate)
Dichte	1.0697 (rough estimate)
Brechungsindex	33 ° (C=1, Pyridine)
storage temp.	room temp
Löslichkeit	Soluble to 0.05 mg/mL (0.16 mM) in DMSO
pka	13.10±0.60(Predicted)
Aggregatzustand	Solid
Farbe	Light yellow to yellow
Wasserlöslichkeit	soluble in chloroform, DMSO (0.05 mg/ml), acetone (slightly ), ethanol (<1 mg/ml at 25°C), and water (<1 mg/ml at 25°C).
Merck	14,3741
BRN	1889895
InChIKey	CHNXZKVNWQUJIB-CEGNMAFCSA-N
CAS Datenbank	434-03-7
NIST chemische Informationen	Ethisterone(434-03-7)

Sicherheit

Kennzeichnung gefährlicher	Xn,T
R-Sätze:	40-48-61
S-Sätze:	22-24/25-45-53
RIDADR	UN 2811
WGK Germany	3
RTECS-Nr.	TU5570250
HS Code	29372390

Gefahreninformationscode (GHS)

Ethisterone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
R48:Gefahr ernster Gesundheitsschäden bei längerer Exposition.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Ethisterone is an orally bioavailable synthetic progestin and a derivative of testosterone (Item Nos. ISO60154 | 15645) that binds to progesterone and androgen receptors (EC₅₀s = 23 and 23.1 nM, respectively, in yeast). Ethisterone (1 μM) downregulates progesterone receptors in MCF-7 cells.
Chemische Eigenschaften
Off-White Powder
Originator
Lutocyclin,Ciba
Verwenden
Synthetic progestogen; metabolite of Danazol; intermediate in the synthesis of Spironolactone
Verwenden
Ethisterone has been used as a component in Dulbecco′s modified eagle medium (DMEM) to culture the transfected COS-7 cell for transient transfection assay and?gene transfection assay.
Definition
ChEBI: A 17beta-hydroxy steroid that is testosterone in which the 17beta hydrogen is replaced by an ethynyl group. Ethisterone was the first orally active progestin and is a metabolite of danazol.
Manufacturing Process
0.5 part of δ5:6-17-ethinyl-androstendiol-(3:17) is dissolved in 10 parts of dry acetone, the solution is mixed with a solution of 1 part of tertiary aluminum butylate in 40 parts of absolute toluene and the whole is heated to boiling in a reflux apparatus for 21 hours. After the reaction mixture has cooled it is diluted with 100 parts of ether, the solution is washed with dilute mineral acid and with water, dried and the solvent is evaporated. In this manner there is obtained δ5:6-17-ethinyl-androstene-3-one-17-ol (ethisterone); MP: 270°- 272°C; it may be recrystallized from ethyl acetate.
Therapeutic Function
Progestin
Allgemeine Beschreibung
Ethisterone is a?progestogen. It is a danazol derivative.
Biochem/physiol Actions
Ethisterone acts as a progestational agent. It is consumed by pregnant mothers to prevent miscarriage.

Ethisterone Upstream-Materialien And Downstream Produkte

Ethisteron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

434-03-7, Ethisterone Verwandte Suche:

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