3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacy-clotetradecin-1,7(8H)-dion,(S-(E))-

Bezeichnung:3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacy-clotetradecin-1,7(8H)-dion,(S-(E))-

CAS-Nr17924-92-4

Englisch Name:Zearalenone

CBNumberCB4131407

SummenformelC18H22O5

Molgewicht318.36

MOL-Datei17924-92-4.mol

Synonyma

[S-(E)]-3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dion

3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacy-clotetradecin-1,7(8H)-dion,(S-(E))-

3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacy-clotetradecin-1,7(8H)-dion,(S-(E))- physikalisch-chemischer Eigenschaften

Schmelzpunkt	164-165°C
alpha	25546 -170.5° (c = 1.0 in CH3OH)
Siedepunkt	377.53°C (rough estimate)
Dichte	1.1270 (rough estimate)
Brechungsindex	1.6120 (estimate)
Flammpunkt	6 °C
storage temp.	2-8°C
Löslichkeit	DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml; Ethanol: 20 mg/ml
pka	7.58±0.40(Predicted)
Aggregatzustand	Solid
Farbe	Off-white
Merck	13,10169
BRN	1350216
InChIKey	MBMQEIFVQACCCH-QBODLPLBSA-N
LogP	3.830 (est)
CAS Datenbank	17924-92-4(CAS DataBase Reference)
EPA chemische Informationen	Zearalenone (17924-92-4)

Sicherheit

Kennzeichnung gefährlicher	C,Xn,F
R-Sätze:	34-62-63-36-20/21/22-11
S-Sätze:	26-36/37/39-45-36-16-36/37
RIDADR	UN 3261 8/PG 2
WGK Germany	3
RTECS-Nr.	DM2550000
F	10
HS Code	29322090
Giftige Stoffe Daten	17924-92-4(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Zearalenone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
R62:Kann möglicherweise die Fortpflanzungsfähigkeit beeinträchtigen.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
R36:Reizt die Augen.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R11:Leichtentzündlich.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
Crystalline Solid
Verwenden
Zearalenone is a resorcylic acid lactone produced by a number of Fusarium sp.. Zearalenone acts as a non-steroidal estrogen, binding to estrogen receptor and is uterotropic. Zearalenone induces reproductive problems in animals and, in some animal models, is thought to be a primary initiator of hepatic tumours. In vivo, zearalenone undergoes metabolic reduction to the more estrogenic zearalenol. Contamination of grains, notably maize, by Fusarium species gives rise to high levels of zearalenone and is regarded as an important food quality issue for both humans and animal health.
Verwenden
A phytoestrogenic mycotoxin and ER activator
Verwenden
Estrogenic mycotoxin produced by Fusarium fungi commonly found in grains. One of a group of compounds known as resorcylic acid lactones
Definition
ChEBI: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Allgemeine Beschreibung
White microcrystals or white powder.
Air & Water Reaktionen
Zearalenone may be sensitive to prolonged exposure to air. Insoluble in water.
Reaktivität anzeigen
Zearalenone is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Zearalenone may be incompatible with alkalis.
Brandgefahr
Flash point data for Zearalenone are not available. Zearalenone is probably combustible.
Biochem/physiol Actions
Zearalenone, a fungal mycotoxin produced by Fusarium, binds the estrogen receptor (ER) and is uterotropic in the newborn rat. It is a common contaminant in cereal grain used for animal and human food, and exerts an estrogenic activity that modulates/disrupts endocrine function in animals and possibly humans.
Stoffwechselwegen
When zearalenone is subjected to microbial transformation by a fungus, Gliocladium roseum, it is converted to a 1 : 1 mixture of 1-(3,5-dihydroxyphenyl)- 10 0 -hydroxy-1-undecen-6'-one and 1-(3,5- dihydroxyphenyl)-6'-hydroxy-1-undecen-10'-one.
Lager
-20°C

Zearalenone Upstream-Materialien And Downstream Produkte

3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacy-clotetradecin-1,7(8H)-dion,(S-(E))- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

17924-92-4, Zearalenone Verwandte Suche:

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