ALPHA-ZEARALENOL

Bezeichnung:ALPHA-ZEARALENOL

CAS-Nr36455-72-8

Englisch Name:ALPHA-ZEARALENOL

CBNumberCB8491950

SummenformelC18H24O5

Molgewicht320.38

MOL-Datei36455-72-8.mol

ALPHA-ZEARALENOL physikalisch-chemischer Eigenschaften

Schmelzpunkt	158-161°C
Siedepunkt	599.0±50.0 °C(Predicted)
Dichte	1.174±0.06 g/cm3(Predicted)
Flammpunkt	2℃
storage temp.	-20°C
Löslichkeit	≤20mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
Aggregatzustand	crystalline solid
pka	7.61±0.60(Predicted)
Stabilität	Hygroscopic

Sicherheit

Kennzeichnung gefährlicher	Xn,T,F
R-Sätze:	20/21/22-40-52/53-68/20/21/22-36-11-62-48/20-63-46-45
S-Sätze:	36/37-61-16-45-53
RIDADR	UN 1648 3 / PGII
WGK Germany	3
F	8
HS Code	29322090

Gefahreninformationscode (GHS)

ALPHA-ZEARALENOL Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R52/53:Schädlich für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R68/20/21/22:Gesundheitsschädlich: Möglichkeit irreversiblen Schadens durch Einatmen,Berührung mit der Haut und durch Verschlucken.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Beschreibung
α-Zearalenol is a major hepatic metabolite of zearalenone , a mycotoxin produced by fungi in food and animal feeds. It is a less potent agonist of estrogen receptors than the parent compound. However, α-zearalenol has pronounced effects on uterotropic activity, sperm motility, and preimplantation embryonic development.
Chemische Eigenschaften
Off-White Solid
Verwenden
The major metabolites of Zearalenone
Verwenden
α- Zearalenol may be used as an analytical reference standard for the determination of the analyte in traditional medicinal herbs, human and animal urine by various chromatography techniques.
Verwenden
α-Zearalenol is a mycotoxin produced by several species of Fusarium. α-Zearalenol exhibits pronounced estrogenic activity, being 3-fold more active than zearalenone. Contamination of grains, notably maize, by Fusarium species gives rise to high levels of zearalenol and is regarded as an important food quality issue for both humans and animal health.
Definition
ChEBI: Alpha-Zearalenol is a macrolide.
Biochem/physiol Actions
α-Zearalenol (α-ZOL) is a catabolite of zearalenone, synthesized majorly in granulosa cells, intestine and liver in pigs. It has estrogenic functionality. α-ZOL inhibits sperm motility in horse possibly by eliciting genotoxic effect. α-ZOL displays higher affinity towards estrogenic receptors.
in vitro
the binding characteristic of α-zea was less potent with estrogen receptors than the parent compound [2]. α-zearalenol showed pronounced effects on uterotropic activity [3]. α-zea inhibited normal sperm motility, but stimulated hyperactive motility in the remaining motile cells and simultaneously induced the acrosome reaction [4].
Einzelnachweise
[1]. zinedine a, soriano j m, molto j c, et al. review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin[j]. food and chemical toxicology, 2007, 45(1): 1-18.
[2]. kiang d t, kennedy b j, pathre s v, et al. binding characteristics of zearalenone analogs to estrogen receptors[j]. cancer research, 1978, 38(11 part 1): 3611-3615.
[3]. mirocha c j, pathre s v, behrens j, et al. uterotropic activity of cis and trans isomers of zearalenone and zearalenol[j]. applied and environmental microbiology, 1978, 35(5): 986-987.
[4]. filannino a, stout t a e, gadella b m, et al. dose-response effects of estrogenic mycotoxins (zearalenone, alpha-and beta-zearalenol) on motility, hyperactivation and the acrosome reaction of stallion sperm[j]. reproductive biology and endocrinology, 2011, 9(1): 134.

ALPHA-ZEARALENOL Upstream-Materialien And Downstream Produkte

ALPHA-ZEARALENOL Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

36455-72-8, ALPHA-ZEARALENOL Verwandte Suche:

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